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Biomedical subjects

M Dandine

Publications and source records attributed to M Dandine.

At least 19 recordsLinked to original sources
PubMed1999

Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes.

Uncoupling protein-2 (UCP2) is a novel mitochondrial protein that may be involved in the control of energy expenditure. We have previously reported an upregulation of adipose tissue UCP2 mRNA expression during fasting in humans. Analysis of changes in metabolic parameters suggested that fatty acids may be associated with the increased UCP2 mRNA level. Culture of human adipose tissue explants was used to study in vitro regulation of adipocyte UCP2 gene expression. A 48-h treatment with BRL49653 and bromopalmitate, two potent activators of PPARgamma, resulted in a dose-dependent increase in UCP2 mRNA levels. The induction by BRL49653 was rapid (from 6 h) and maintained up to 5 days. TNFalpha provoked a 2-fold decrease in UCP2 mRNA levels. Human recombinant leptin did not affect UCP2 mRNA expression. The data support the hypothesis that fatty acids are involved in the control of adipocyte UCP2 mRNA expression in humans.

Adipocytes↗
PubMed1985

De novo interstitial deletion of the long arm of chromosome 7:46,XY,del(7)(q23;q32).

A de novo interstitial deletion of the long arm of chromosome 7 is reported in a newborn boy. Our observation is compared with seven others deletions of the same bands. Clinical features showed the following: hypotonia, microcephalia, difficulty in swallowing, low-set dysplastic ears, an abnormal cry, upslanting and small palpebral fissures, and abnormalities of the hands and feet. Delayed mental and physical development is the general rule, and visceral malformations are uncommon. Our patient had genital abnormalities and a cardiac malformation.

Abnormalities, Multiple↗
PubMed1984

[Kniest's disease].

A one year old child with Kniest's disease was admitted for reconstructive surgery of the bone deficit of a palatine cleft. This syndrome is recognizable at a very early age by the shortness of the limbs or the increase in size of the joints. Clinically it associates mild facial dystrophy and nanism from reduction in height of the trunk and the shortness and deviations of the limbs. Frequently associated are myopia, deafness and a palatine cleft. Radiological signs are reduced height of vertebral bodies, and a not infrequent finding is a cuneiform deformity of the first lumbar vertebrae. Epiphyseal development is anarchic, that of the knee large, while the femoral head is small, fragmented or absent. Transmission is by the dominant mode. Kniest's syndrome must be differentiated from metratropic dwarfism in which there is greater progression of spinal deformities.

Abnormalities, Multiple↗
PubMed1983

[Rothmund-Thompson syndrome with glaucoma. Endocrine study].

Two cases of Rothmund-Thomson syndrome in siblings are described. The elder patient, whose case was best documented and who was followed for several years, had the characteristic skin changes of poikiloderma congenitale with small stature and mental deficiency. Upon ophthalmologic examination, this patient was shown to have bilateral glaucoma which was treated surgically, while the cataract typically found in Rothmund-Thomson syndrome was lacking. Primary hypogonadism was confirmed by endocrinologic investigations; anterior pituitary hormones were normally released. With reference to this observation differential diagnosis is discussed; the medical literature is reviewed.

Abnormalities, Multiple↗
PubMed1983

[Purulent pericarditis with a subacute constrictive course. Apropos of a case. Review of the literature].

A case of purulent pericarditis due to Hemophilus influenzae is reported. In spite of management by antibiotics and pericardial drainage, the disease ran a subacute course towards pericardial constriction. Fifty-two previously reported cases are reviewed. The most important clinical and paraclinical features are analyzed. Emphasis is put on the factors which promote subacute pericardial constriction.

Anti-Bacterial Agents↗