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Biomedical subjects

M Dalmasso

Publications and source records attributed to M Dalmasso.

17 recordsLinked to original sources

On-line quantitative coronary analysis in clinical practice: one step closer to reality?

Quantitative coronary analysis is widely used in studies of progression/regression and restenosis of coronary lesions. On-line digital systems are used in diagnostic coronary angiography, and as a guide in coronary interventions. The aim of this investigation was to test the reliability of measures obtained with one commercially available on-line equipment. Well-visualized coronary lesions from patient studies were analyzed for variability in single-frame measurement. Procedural factors affecting the consistency of measurements were identified by repeated visualization of the same coronary lesion with hand- and power-injection of contrast in various positions in the field of the image intensifier, and by imaging of steel phantoms in the same positions. Steel phantoms closely resembling coronary lesions as encountered in practice were visualized in the most favourable radiologic setting compatible with clinical situations. Accuracy and precision of measurements were found to be worse than reported in validation studies. This may be due to a host of variables which may need to be tested in each laboratory performing on-line quantitative coronary angiography, when data so obtained are to be used in clinical decision making or in research studies.

Artifacts

[Cardiac arrhythmias during dialysis. An unresolved problem].

The incidence of the arrhythmias in 47 patients subjected to chronic hospital dialysis using different techniques has been assessed. Cardiopathies and non-cardiopathies were assessed separately. In the first group, no significant differences were observed with respect to the presence of heart rhythm disturbances. The second group showed increased ventricular arrhythmias during the intradialysis and postdialysis period. A statistical correlation was carried out between the presence of arrhythmias and various parameters (technique of dialysis, weight difference, ultrafiltrate/hour, age). The only statistically significant correlation in the non-cardiopathies was age.

Arrhythmias, Cardiac

Severe electrocardiographic abnormalities during arfonad administration.

Severe and reversible electrocardiographic abnormalities (first degree atrioventricular block, left bundle branch block, ventricular fibrillation), were induced by the administration of Arfonad in a patient with type III acute aortic dissection previously chronically treated with alpha-methyl-dopa. Any other possible cause of the electrocardiographic changes was excluded on the basis of clinical findings and laboratory studies. The explanation of the electrocardiographic abnormalities induced by Arfonad are not readily apparent, also on careful review of the literature. We suggest a strict electrocardiographic monitoring during Arfonad administration especially in patients with cardiac conduction defects and previous administration of cardiac cathecholamines depleting drugs.

Adult

[Left atrial myxoma and calcified aortic stenosis in a patient with syncope].

A 59-year-old man who suffered several episodes of syncope had both calcific aortic stenosis and a left atrial myxoma. As syncope occurred during effort, rather than after postural changes, we believe that the symptom was caused by aortic stenosis. In fact the myxoma was only mildly obstructive both by haemodynamic measurements and at visual inspection at surgery.

Aortic Valve Stenosis

[Small fistulas between circumflex coronary artery and left atrium associated with rheumatic valvular cardiomyopathy. A case report (author's transl)].

Multiple small fistulas between the circumflex coronary artery and the left atrium were found in a patient with mitral stenosis, aortic and tricuspid regurgitation. Although their origin was proximal and they drained in a low pressure cavity, the anomalous channels were small and caused no clinically recognizable signs or symptoms. These findings support the view that hemodynamics (and hence clinical manifestations) of coronary artery fistulas are mainly determined by their developmental anatomy.

Aortic Valve Insufficiency