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Biomedical subjects

M D Tilson

Publications and source records attributed to M D Tilson.

At least 109 records · Page 6Linked to original sources
PubMed1976

Abdominal angina. Intestinal absorption eight years after successful mesenteric revascularization.

A woman with panmalabsorption and symptoms characteristic of abdominal angina underwent successful revascularization of the superior mesenteric artery. Laboratory studies obtained eight years postoperatively were compared with preoperative data. Her stool fat was reduced to 29 per cent of the preoperative quantity, although her dietary intake of fat was increased fivefold. The d-xylose tolerance test was increased to 346 per cent of the preoperative value, serum carotenes to 817 per cent, serum albumin to 172 per cent, hematocrit to 148 per cent, and cholesterol to 296 per cent. Her weight had risen from 69 to 122 pounds. We conclude that the panmalabsorptive defect associated with mesenteric vascular insufficiency is reversible and that the intestine may function normally for a prolonged period of time after revascularization.

Abdomen, Acute↗
PubMed1976

A possible explanation for postoperative diarrhea after colostomy closure.

The transient diarrhea that sometimes follows the closure of colostomies has been ascribed to rapid transit in the previously defunctionalized distal colon. However, the present study of the temporarily bypassed colon in the rat indicated that a reduced capacity for the absorption of sodium and water develops within two to three weeks after bypass, without significant decreases in transit time or colon volume. After restoration of continuity, the absorptive capacity for water increased to normal under some of the experimental conditions. It is therefore suggested that postoperative diarrhea after colostomy closure in man may be related to a temporary decrease in absorptive capacity in the previously bypassed distal colon.

Animals↗
PubMed1975

Compensatory hypertrophy of the ileum after gastroduodenojejunal exclusion.

One theory of compensatory hypertrophy of the gut suggests that ileal growth after jejunectomy results from exposure of the ileum to villus-enlarging factors emanating from the papilla of Vater. This hypothesis was tested by examination of the ileum after bypass of pancreatobiliary secretions to the colon. Hypertrophy of the ileum occurred after esophagoileostomy and gastroduodenojejunal exclusion, suggesting that adaptive growth of the gut depends on additional factors. There is evidence to support several theories of compensatory hypertrophy. A hypothesis seeking to reconcile the conflicting notions of intraluminal and hormonal stimuli is suggested.

Ampulla of Vater↗
PubMed1975

Jejunal absorption of bile salts after resection of the ileum.

Malabsorption of bile salts plays a major role in the pathogenesis of diarrhea after resection of the ileum, but the diarrhea usually improves with the passage of time. To test the hypothesis that this improvement may occur as a result of increased absorptive capacity for bile salts in the jejunal remnant, everted sacs of jejunal remnants were prepared 3 months after ileectomy. The mean serosal to mucosal concentration ratio of taurocholate found in the experimental jejunal sacs was increased approximately 70 percent over the mean ratios of normal and sham-resected jejunal preparations (p smaller than 0.05). This change may be a manifestation of cellular adaptation in transport function, suggesting that the scope of intestinal adaptation in short gut syndrome goes beyond morphological hypertrophy and hyperplasia.

Animals↗