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Biomedical subjects

M D Poole

Publications and source records attributed to M D Poole.

At least 91 records · Page 5Linked to original sources
PubMed1985

Peripheral neovascularisation of muscle and musculocutaneous flaps.

The collateral vascularisation of muscle flaps covered by a skin graft and of musculocutaneous island flaps was studied in a pig model using the latissimus dorsi muscle. Vascular ingrowth from the underlying bed was stopped by using silastic sheeting. The time taken for peripheral vascularisation of flaps to render them independent of pedicle blood supply was studied. In addition microangiograms were performed at the time of sacrifice of the animals (4 weeks postop.) to give a visual conception of the sites and sizes of new vessel growth at the periphery of the flaps. Results showed significant delay, in muscle flaps with skin grafts reset onto a poor bed, in obtaining a blood supply independent of the pedicle supply.

Animals↗
PubMed1984

Pyogenic otorhinologic infections in acquired immune deficiency syndrome.

A 25-year-old homosexual man with acquired immune deficiency syndrome had CNS toxoplasmosis, mucosal candidiasis, acute otitis media, and sinusitis. These problems persisted despite multiple courses of antibiotic therapy. Surgical drainage proved to be the only effective means of controlling his otorhinologic infections. We recommend early surgical intervention for this type of patient when standard antibiotic therapy for sinusitis and otitis media proves ineffective.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Local transposition of a distally-based island forearm flap to close a complicated excisional wrist defect in a nonagenarian: some anatomical and clinical considerations.

A distally based island forearm flap was used in a 93-year-old patient to reconstruct a dorsal forearm defect following tumour resection. Augmentation of the venous out-flow using a microvascular venous anastomosis was required. The expediency and safety with which this island flap can be used is emphasized with a cautionary note on venous drainage.

Aged↗
PubMed1981

Edema and hemoconcentration in mice experimentally infected with Vibrio vulnificus.

Vibrio vulnificus (lactose-positive Vibrio), a recently recognized pathogenic marine species, produced extreme hemoconcentration and death within 3 to 6 h after subcutaneous or intraperitoneal injection of 10(8) viable cells into mice; hemotocrit values approached 70% (normal, 45%). About 1 ml of edema fluid accumulated at the site of each subcutaneous injection, and locally increased vascular permeability was demonstrated by a skin bluing assay, using Evans blue dye. A corresponding fluid accumulation did not occur in the peritoneal cavity after an intraperitoneal injection. Filter-sterilized supernatants of cultures grown under a variety of conditions did not produce local edema or lethality, nor did whole Vibrio cells killed by a variety of methods or disrupted by sonic oscillation. Edema fluids collected from infected mice and sterilized by filtration had no effect when they were injected subcutaneously or intraperitoneally into mice. Inocula of 10(9) viable cells of V. vulnificus contained within a diffusion chamber implanted subcutaneously did not produce skin bluing, edema, or lethality; Vibrio cells remained viable and virulent within these chambers for at least 2 weeks. These experiments suggested that vascular permeability changes in V. vulnificus infections may not be attributable to a diffusible toxin and may require direct contact between host cells and viable Vibrio cells.

Animals↗
PubMed1979

Aluminium foil as a wound dressing.

Aluminium foil has been found to be an extremely useful and painless way of dressing wounds prior to delayed skin grafting. However, it is not recommended for use on skin-graft donor sites as it delays epithelial healing.

Aluminum↗
PubMed1978

Experimental pathogenicity and mortality in ligated ileal loop studies of the newly reported halophilic lactose-positive Vibrio sp.

Laboratory animals were challenged subcutaneously, intraperitoneally, and intravenously with the halophilic lactose-positive Vibrio. Intraperitoneal inocula of 10(8) organisms proved to be rapidly lethal in mice, rats, and hamsters. The 50% lethal doese in ICR strain mice was estimatd to be 8 X 10(5) live cells, injected intraperitoneally or subcutaneously. Subtaneous inocula in mice resulted in severe local infections, characterized by gross edema, and for those animals surviving longer than 48 h, tissue necrosis. Intravenous, intraperitoneal, and subcutaneous injections of 10(8) cells in mice resulted in death within 3 to 6 h. These animals rapidly developed Vibrio bacteremia after injections. V. parahaemolyticus, studied for comparative purposes, produced no morbidity or mortality when injected subcutaneously. Injections of live lactose-positive Vibrio into ligated ileal loops in rats and rabbits consistently proved to be lethal with a high-density bacteremia resulting.

Animals↗
PubMed1976

Advanced and recurrent squamous carcinoma of the lower lip.

The results of aggressive surgical treatment of primary lip cancer and advanced and recurrent carcinoma of the lip are illustrated and discussed. Early detection of involved lymph nodes before capsular penetration occurs and careful and complete dissection of the submental and submandibular regions are advocated as possible ways to prevent persistent upper neck disease, the main killer of these patients.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Hemifacial microsomia.

Hemifacial microsomia is variable with respect to the degree of the deformity it presents, thus, treatment varies. Mild degrees of the condition are usually treated adequately by waiting until adolescence, when definitive surgical correction of any skeletal or soft tissue asymmetry can be dealt with. Some mild and moderate cases may benefit from orthodontic functional appliance therapy during growth, but orthodontic opinion is divided on the value of such therapy. Children with severe forms of hemifacial microsomia are improved in appearance during their school years by early surgery performed in the preschool period. A number of surgical approaches have been used at this stage. The technique currently being used by the author involves composite transfer of vascularized soft tissue for contouring, together with a vascularized costochondral strut to lengthen the affected side of the mandible. Early results using this method are satisfactory, but further work is required to assess the advantages of this over other techniques.

Child↗