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Biomedical subjects

M D Poole

Publications and source records attributed to M D Poole.

At least 55 records · Page 3Linked to original sources
PubMed1992

Mid-facial sensation following craniofacial surgery.

During mid-face advancement and correction of orbital dystopia, the infraorbital nerves are always stretched and displaced by the orbital floor osteotomies and bone displacement, and are at risk of damage. We have found no published work that has investigated the function of the infraorbital nerves following elective craniofacial procedures. In this study the cheek sensation and tooth sensibility in 20 patients who have had either mid-face advancement or correction of orbital dystopia was assessed. The function of the infraorbital nerve is largely undisturbed by the osteotomies and bone displacement performed during these procedures. A small proportion of patients could not feel cold in their anterior maxillary teeth, suggesting that there is damage to the anterior superior alveolar nerve branch of the infraorbital nerve.

Adolescent↗
PubMed1992

Prevention of cranial reossification after surgical craniectomy.

An experimental study in rats was designed to see whether the pericranium, used as a graft over the dura, can prevent or delay osseous reunion after craniectomy. A 10 x 3-mm section of the frontal and parietal bones, including the coronal suture line, was resected in 15 rats. Pericranium was then used as a free graft on one-half of the defect to cover the dura and separate it from the cut edges of the craniectomy. The other side acted as a control. All animals were killed 2 months after operation, the skull was removed, and any remaining bony defect on either side of the midline was revealed. The area of residual defect in 13 specimens was determined by statistical image analysis using the Oxford Modular Cataract Image Analysis System (Oxford, England) and Wilcoxon's rank sum test and showed a highly significant difference between the treated and the untreated sides (p = 0.002).

Animals↗
PubMed1991

Reanimation for facial palsy using gracilis muscle grafts.

Twelve patients have been reviewed at least 2 years after gracilis muscle transfer, preceded by crossface nerve grafting, for complete unilateral facial palsy. Levels of satisfaction among the patients were good. Examination showed all had voluntary movement of the graft which could produce reasonable mouth symmetry in most patients. However, the involuntary spontaneity and expressive movements were not so satisfactory, though still worthwhile. The technique and some lessons learned from this experience are discussed. It appears from electromyographic studies that continuing innervation and activity can occur in these grafts for many years postoperatively.

Adolescent↗
PubMed1991

Characterization of cough associated with angiotensin-converting enzyme inhibitors.

Chronic cough is a side effect of the angiotensin-converting enzyme (ACE) inhibitor class of antihypertensives. The cough is thought to be a result of inhibition of the enzymes that break down some of the mediators of inflammation, such as the bradykinins and tachykinins. We report 20 patients with chronic cough caused by ACE inhibitors and some of the characteristics of the cough. The cough is typically dry, nonproductive, and worse at night. Interference with sleep is common and was severe in three patients. Women outnumbered men in this series: urinary stress incontinence developed in five, rectal and vaginal prolapse developed in one. Three patients felt they were incapacitated by the cough. Most had been on multiple medications; only oxycodone was reported to be effective in controlling the cough, and four patients thought they were addicted to that. All coughs resolved with withdrawal of the ACE inhibitor. Chronic cough is common among individuals taking ACE inhibitors. It may be severe and associated with complications. The incidence and potential severity is understated in drug information sources, and patients and physicians often fail to recognize cough as a drug side effect.

Adult↗
PubMed1990

Nasolacrimal abnormalities in oblique facial clefts.

A patient with a Tessier No. 4 cleft and an associated bifid nasolacrimal system is presented and considered within the Tessier classification of craniofacial clefting. Previous accounts of nasolacrimal abnormalities associated with facial clefts are reviewed together with the accepted developmental embryology. It is proposed that the bifid nasolacrimal duct system described constitutes a new addition to the literature.

Abnormalities, Multiple↗
PubMed1990

The cranio-facio-cervical scoliosis complex.

Six patients are presented with facial asymmetry including vertical orbital dystopia in association with torticollis. All six have also had other abnormalities. Some degree of hemifacial microsomia was present in five of the six, a so-called plagiocephalic or rhomboid skull with normal cranial sutures in four of the six, and cervical spine anomalies in four of the six. Other deformities have also been noted. The condition is best named the cranio-facio-cervical scoliosis complex. The implications for treatment of the facial asymmetry, in particular the unequal levels of the orbits in the established deformity, are discussed and a surgical plan which has been used in four patients described.

Abnormalities, Multiple↗
PubMed1990

Radioimmunodetection of human melanoma.

Radioimmunodetection has been shown to be an invaluable method in the diagnosis of primary and metastatic malignant disease. Fourteen patients, consisting of four men and 10 women with clinical suspicion of metastatic malignant melanoma or ocular melanoma were prospectively evaluated with the technique. Ten (71%) had positive and four (29%) had negative scintigrams. There was one false-positive scintigram. The overall sensitivity and specificity were 100% and 80%, respectively. SPET was necessary for the radioimmunodetection of patients with ocular melanoma. Combined immunoscintigraphy and immunolymphoscintigraphy enhanced the diagnosis of small, cutaneous melanoma and metastatic lymph node disease.

Adult↗