Biomedical subjects

M D Morrison

Publications and source records attributed to M D Morrison.

At least 37 records · Page 2Linked to original sources

PubMed1984

Paranasal sinus malignancy--a retrospective analysis of treatment methods.

A retrospective analysis has been made of all cancers of paranasal sinuses seen at the Cancer Control Agency in Vancouver during the years 1970 to 1978. The overall crude five year survival for all cases (49) was 46%. A combined treatment using irradiation and surgery in selected cases generated a five year survival rate of 74.4% as compared to 42.1% in cases receiving irradiation alone. The clinical presentation, staging, and the need for the individualization of treatment methods based on a realistic knowledge of the pathological extent of the disease are discussed.

Adenocarcinoma↗

PubMed1983

Acoustic analysis of voice for computerized laryngeal pathology assessment.

The purpose of this paper is to review the techniques of computerized acoustic analysis of voice signals used for laryngeal pathology assessment. Results of using a methodology described by Davis for distinguishing between T1 glottic cancer, noncancerous pathology, and normal speakers are presented. These results indicate that this technique is not sufficiently sensitive for general clinical usefulness. There is an intentional lack of mathematical detail in this paper, as its prime intent is to conceptually outline issues and approaches.

Adolescent↗

PubMed1983

The voice clinic: an interdisciplinary approach.

The University of British Columbia Voice Clinic provides care to patients with various types of voice disorder, and the effectiveness of therapy is enhanced by an interdisciplinary approach. The Voice Clinic team includes an otolaryngologist, speech pathologist, psychiatrist, and singing teacher consultant. This paper particularly highlights the interactions between the speech pathologist and psychiatrist in their therapy programs for voice disordered patients.

British Columbia↗

PubMed1983

Muscular tension dysphonia.

Muscular tension dysphonia (MTD) is a condition commonly seen in young and middle aged females. It is manifest by excess tension in the paralaryngeal and suprahyoid muscles, an open posterior glottic chink, larynx rise, and frequently mucosal changes on the vocal cords. These mucosal changes are usually fleshy vocal nodules. About 8% of vocal nodules are found in patients not exhibiting features of MTD. The two types of vocal nodules require different therapeutic approaches. One hundred patients out of 500 seen consecutively at the Voice Clinic at the University of British Columbia exhibited the features of MTD. These patients are discussed and an etiology hypothesis is presented.

Adolescent↗

PubMed1983

Anatomic correlation for muscle tension dysphonia.

Dysphonia resulting from increased muscular tension in the larynx and neck is associated with 1) palpably increased phonatory muscle tension in the paralaryngeal and suprahyoid muscles, 2) elevation of the larynx in the neck on increasing vocal pitch, 3) an open posterior glottic chink between the arytenoid cartilages on phonation, and 4) variable degrees of mucosal changes such as vocal nodules or chronic laryngitis. Using six cadaver larynges, the glottic features observed during examination of patients with muscular tension dysphonia (MTD) are reproduced. In each larynx the posterior, lateral, and interarytenoid muscles were dissected free and tension applied in the direction of action in various combinations. Glottic changes were observed, recorded on videotape, and compared to similar clinical video recordings.

Cadaver↗

PubMed1982

Prognostic factors in primary tracheal malignancy.

Published literature discussing factors influencing prognosis in primary malignancy of the trachea is reviewed. Twenty-four patients with primary tracheal malignancies presenting during an 11 year period are discussed. Review of their radiological investigations demonstrate that extratracheal extension correlates with poor prognosis whereas vertical length of tumors does not. Overall five year survival in this series is 30%. Patients with extratracheal extension show 18% five year survival while those with only intraluminal disease show 50% survival.

Aged↗

PubMed1979

Teratomas of the nasopharynx.

The case of an infant with a large nasopharyngeal teratoma is presented. The tumor completely obstructed the airway and necessitated immediate intubation. It was excised the day of birth and the child's postoperative course has been satisfactory. A review of the literature reveals dermoid tumors to be relatively common but teratomas occur considerably less frequently. Four previously reported cases with successful surgical excision were found. The etiology of these lesions is unknown. They probably arise from uncontrolled growth of a pleripotential cell originating in the region of the embryonic notochord. Dermoid tumors often present in the adolescent or adult. Teratomas however, generally present in the neonate and are incompatible with life without surgical excision which provides the only chance of survival for these infants.

Airway Obstruction↗

PubMed1978

Early detection of childhood hearing impairment - problems and possible solutions.

The identification of infants with profound hearing loss is a complex task, and one that is beset with problems. This paper discusses some of these problems and points out a few of the ways by which, hopefully, they are coming closer to solution. The first problem results from the nature of the beast, which seems to have so many social, medical, educational, and political implications. There are also some problems with the high risk register and with screening for hearing loss; but probably the most disturbing are the conflicts that arise between professionals when their aims, objectives, and methods don't quite match. Current progress in the linking up of high risk and screening methodologies is discussed, as well as ways in which existing health care systems can be utilized in deafness detection.

Audiology↗

PubMed1978

The effects of indomethacin on inner ear fluids and morphology.

Metabolic disturbances may affect inner ear fluid homeostasis in various ways. The membrane sodium-potassium pump must play a role in this homeostasis, and as this pump derives energy from A.T.P. it may also depend somewhat on the presence of prostaglandins, through their stimulatory effect on the adenylate cyclase system. Salicylates suppress prostaglandins; and Indomethacin is even more potent in this respect. Could the temporary ototoxic effects of salicylates and Indomethacin be due to prostaglandin suppression? Further, could energy system problems involving prostaglandins be related to the development of endolymphatic hydrops? These questions prompted this study. Sublethal doses of Indomethacin were given to 14 guinea pigs in order to maximally suppress prostaglandins. Samples of perilymph and endolymph were analyzed for sodium and potassium concentrations and compared to normal controls. No significant differences were found in either acute (two to 24 hour) or chronic (three week) experiments. Light microscopic examination of serially sectioned cochleae in similarly treated animals showed, in a few cases, somewhat questionable distension of Reissner's membrane. Electron microscopy or the organ of Corti did not demonstrate any abnormalities. The study suggests that Indomethacin does not produce significant inner ear electrolyte shifts or endolymphatic distension, at least over the short term.

Animals↗

PubMed1978

Congenital tracheal web--a case report.

Congenital tracheal webs are rare. This report involves an eight year old girl presenting with a six year history of frequent colds, wheezing, and dyspnea in whom the tracheal web was successfully excised after failure of bronchoscopic dilation. Tracheal embryology is briefly reviewed and tracheal stenoses are classified. A history of recurrent chest infection and finding of stridor are the chief of recurrent chest infection and the finding of stridor are the chief features ot his lesion. Lateral chest roentgenogram, tracheal tomography, and bronchoscopy are useful in establishing the diagnosis.

Child↗

PubMed1977

The radiologic diagnosis of pneumocele of the maxillary sinus.

Pneumocele of the maxillary sinus is a recently described disease, first noted in 1974. Three subsequent cases have been encountered. Pneumocele refers to an expansile cystic air-containing mass, occupying the entire maxillary sinus, and lined by the original attenuated mucous membrane. It is analogous to mucocele, but containing air rather than fluid content. Radiologic signs are diagnostic, and it is the purpose of this presentation to enumerate these radiologic findings.

Adolescent↗

PubMed1977

Crico-arytenoid joint obliteration following longterm intubation in the premature infant.

Twin male premature infants suffering from hyaline membrane disease were intubated with Cole endotracheal tubes. One died at 25 weeks of age of cor pulmonale, still intubated. The other died at 32 weeks, six weeks after tracheotomy. Both larynges were serially sectioned and compared to normal. The crico-arytenoid joints were destroyed by inflammatory granulation tissue, and later obliterated by fibrous tissue. The probable pathogenesis and implications are discussed.

Cricoid Cartilage↗

PubMed1976

Pneumocele of the maxillary sinus. Report of a case.

The first two cases of pneumocele of the maxillary sinus have been recently published. The expanded antrum produced a different initial complaint in each case. A third case, with yet another initial problem, middle ear effusion, is now reported. The roentgenographic and operative findings and the therapeutic effect of decompression by antrostomy would suggest that this is a specific disease entity, presumably due to a check valve obstruction of the sinus ostium.

Air↗

PubMed1976

Thoracotracheostomy.

When laryngeal carcinoma extends into the cervical trachea, peritracheal nodes, prelaryngeal tissues and skin, or when it recurs at the tracheal stoma, the prognosis becomes rather dismal. To have a hope of cure, a palliative excision must be radical. Developments in the surgical techniques for exposure, excision, and reconstruction which have evolved during the past quarter century are reviewed, along with a case presentation through which the problems and techniques are illustrated.

Carcinoma, Squamous Cell↗

PubMed1974