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Biomedical subjects

M D Mann

Publications and source records attributed to M D Mann.

89 records · Page 5Linked to original sources
PubMed1975

Potassium supplementation, serum immunoreactive insulin concentrations and glucose tolerance in protein-energy malnutrition.

The serum immunoreactive insulin (IRI) concentrations, and glucose dissappearance rate-constants after intravenous glucose administration were measured on admission and during recovery in children suffering from protein-energy malnutrition (PEM). 2. A high potassium intake resulted in a considerable increase in the serum IRI levels early in the treatment period. There was a definite relationship between potassium depletion and many measurements of insulin secretion. 3. The results are consistent with the hypothesis that impaired insulin release in children suffering from PEM is partly the result of potassium depletion.

Blood Glucose↗
PubMedDate not supplied

Secondary sexual development of 'Cape Coloured' girls following kwashiorkor.

This report describes the secondary sexual development of 45 'Cape Coloured' female ex-kwashiorkor patients and 43 female controls. All patients were originally seen between five months and four years four months of age, treated and then followed up for 15 years after discharge. Age at menarche was available on 42 ex-patients and 33 controls, and age at peak height velocity (PHV) was available for 30 ex-patients and 15 controls. Maximum likelihood estimates of the mean age at entry to each pubertal stage were made, age at menarche was obtained directly from the subject records and age at PHV was obtained by fitting a non-linear growth function to the data for each subject. All subjects passed through the sequence of pubertal events in the normal order, i.e., no reversals were observed. Ex-patients were generally delayed in relation to controls but there were no significant differences for ages at entry to any of the pubertal stages. The subjects were combined for comparison to equivalent data on British girls. The South African girls were significantly delayed in the development of pubic hair and menarche but showed no significant differences for age at entry or duration of breast development and PHV. It is suggested that lack of delay in breast development may have selective advantages to females living in situations of chronic malnutrition.

Female↗
PubMedDate not supplied

Secondary sexual development of Cape coloured boys following kwashiorkor.

This report describes the secondary sexual development of 78 Cape Coloured male ex-kwashiorkor patients and 53 male controls. All patients were originally seen between 5 months and 4 years 4 months of age, treated and then followed up for 15 years after discharge. Age at peak height velocity (PHV) was available for 23 ex-patients and 15 controls. Maximum likelihood estimates of the mean age at entry to each pubertal stage were made and age at PHV was obtained by fitting a non-linear growth function to the data for each subject with appropriate serial height records. No significant differences were observed between ex-patients and controls for either the sequence of pubertal events or for the age of entry to each stage. When compared to a sample of normal British boys the Cape Coloured sample exhibited significant delay for ages at entry to all pubertal stages with differences ranging from 0.84 years for PH2 to 1.94 years for PH5. It is suggested that adrenal androgens play a major role in delaying secondary sexual development during chronic malnutrition and that the anterior pituitary's response to such conditions is to selectively delay pubertal status.

Adolescent↗
PubMedDate not supplied

Duodenal microflora in infants with acute diarrheal disease.

The duodenal microflora was determined qualitatively and quantitatively in a group of infants early in the course of diarrheal disease. Abnormal bacterial overgrowth in the duodenal aspirate was demonstrated in 70%. Coliforms and bacteroides species were present in significant numbers in 53%. No differences were found in the duodenal microflora distinguishing infants whose diarrhea persisted after 7 days in the hospital from those whose diarrhea resolved earlier.

Acute Disease↗