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Biomedical subjects

M D Hall

Publications and source records attributed to M D Hall.

66 records · Page 4Linked to original sources
PubMed1981

Hypophysectomy does not prevent development of striatal dopamine receptor supersensitivity induced by repeated neuroleptic treatment.

Hruska et al. (1980) reported that hypophysectomy prevented the onset of dopamine receptor supersensitivity. We have repeated this investigation administering haloperidol (0.75 mg/day) or sulpiride (2 X 15 mg/day) or saline for 17 days, followed by a 3 day drug washout period, to sham-operated or hypophysectomised rats. Haloperidol or sulpiride pretreatment caused an enhancement of apomorphine-induced stereotyped behaviour and increased the number of specific striatal [3H]spiperone binding sites (Bmax) in both hypophysectomised and sham-operated animals compared to their respective saline controls. We conclude that hypophysectomy does not prevent the onset of striatal dopamine receptor supersensitivity induced by repeated neuroleptic treatment in the rat.

Animals↗
PubMed1976

Reconstruction of the breast after mastectomy for cancer.

Seventeen women who had had a mastectomy for cancer of the breast underwent reconstructions. Alloplastic implants were used in all. Preservation of the nipple and areola was possible in some of these patients. The normal (or uninvolved) breast sometimes required reduction in size or reshaping, to match as nearly as possible the reconstructed breast. The conditions suitable and unsuitable for mammary reconstruction, after mastectomy for cancer, are discussed.

Breast↗
PubMedDate not supplied

Striatal lesions and transplants demonstrate that cholecystokinin receptors are localized on intrinsic striatal neurones: a quantitative autoradiographic study.

Considerable evidence supports the existence of modulatory interactions between cholecystokinin and dopamine in the striatum. In order to explore further the nature of such interactions, the anatomical localization of CCK receptors in rat striatum was investigated autoradiographically following selective lesions. Infusion of 6-hydroxydopamine into the medial forebrain bundle had no effect on striatal CCK receptor content. In contrast, destruction of striatal cell bodies with ibotenic acid or quinolinic acid markedly reduced the number of striatal [125I]CCK-8 binding sites. CCK receptor levels were restored to normal following transplantation of neonatal striatal tissue into rats previously treated with ibotenic acid. These results suggest that CCK receptors are located primarily on intrinsic striatal neurones and not on nigrostriatal afferent fibres.

Animals↗