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Biomedical subjects

M D Feldman

Publications and source records attributed to M D Feldman.

108 records · Page 6Linked to original sources
PubMed1986

Fibrous dysplasia of the paranasal sinuses.

Fibrous dysplasia (FD) of the paranasal sinuses is rare and often presents a diagnostic challenge. It is usually secondary to extension of disease from adjacent bones and is rarely limited to the sinuses. We have described three cases of FD involving the paranasal sinuses, including the first reported case of FD isolated to the sphenoid sinus. A brief update of the clinical aspects, radiographic appearance, diagnosis, and management of craniofacial FD is provided.

Adolescent↗
PubMed1986

The syndrome of anticholinergic intoxication.

Over 600 compounds, including prescription and over-the-counter medications, may cause anticholinergic toxicity. Diagnosis of this potentially fatal condition rests on a detailed history and observation of peripheral and central anticholinergic signs. While supportive therapy is sufficient in most patients, some require treatment with physostigmine. Patient education, judicious drug selection and regular reviews of patients' medications will reduce the risk of anticholinergic toxicity.

Aged↗
PubMed1975

Isolation of foamy virus from rhesus, African green and cynomolgus monkey Leukocytes.

Foamy virus (FV) was recovered regularly from the leukocyte of rhesus and cynomolgus monkeys and somewhat less often from African green monkey leukocytes. Virus was found in virtually all organs of experimentally infected rhesus monkeys. No illness or pathologic abnormalities were noted in these animals or in any of the naturally infected animals in spite of the prolonged period of viral persistence in various organs and tissues.

Animals↗
PubMedDate not supplied

The challenge of self-mutilation: a review.

The challenge of self-mutilation among humans arises from the imprecision of much of the existing literature, as well as the countertransference such disturbing behavior mobilizes. Self-mutilation is defined as an individual's intentionally damaging a part of his or her own body apparently without a conscious intent to die. The importance of understanding this behavior is reflected in the frequency with which it is encountered among psychiatric patients, particularly those diagnosed with borderline personality disorder or schizophrenia. The distinguishing characteristics of dermal, ocular, and genital self-mutilation illustrate the diverse clinical settings in which mutilation arises. Numerous explanations with differing degrees of complexity and merit have been offered; yet, no clear consensus has emerged. Psychotherapy, behavior therapy, and chemotherapy, while controversial, remain the most compelling treatment options. Salient areas for further study include epidemiology both for specific groups and the general population, possible biologic bases for the behavior, and additional management options.

Countertransference↗
PubMedDate not supplied

Relationship between left ventricular wall thickness and left atrial size: comparison with other measures of diastolic function.

We postulated that in patients with essential hypertension and normal left ventricular (LV) systolic function, left atrial (LA) size correlates with LV wall thickness by better reflecting the chronicity and duration of LA hypertension than the commonly used hemodynamic and Doppler measures of LV diastolic function. Accordingly, hemodynamic, Doppler, and two-dimensional echocardiographic measurements were performed in 30 subjects with no cardiovascular abnormalities other than essential hypertension (mean systolic blood pressure of 150 +/- 29 mm Hg). The mean LV wall thickness was 0.57 +/- 0.14 cm/m2 and the mean LV ejection fraction was 0.62 +/- 0.12. Hemodynamic and Doppler measures including pulmonary capillary wedge and LV end-diastolic pressures, isovolumic LV pressure relaxation, LV chamber elastic stiffness, and E/A ratio (E and A waves on the pulsed Doppler signal of the mitral valve) correlated poorly (r = 0.01 to -0.52) with LV wall thickness. Both E/A ratio and isovolumic LV pressure relaxation correlated better (p = 0.05) with patient age than with LV wall thickness. In contrast, LA area (in the apical four-chamber view) had a good correlation (r = 0.77 for LA area in atrial diastole and r = 0.86 for LA area in atrial systole) with LV wall thickness. Multiple regression analysis revealed LA area in atrial systole to be the best correlate of LV wall thickness. We conclude that because the left atrium is a thin-walled structure, its size may increase with an increase in LA pressure. In the absence of mitral valve disease and atrial fibrillation, LA size may reflect the chronicity and duration and thus the history of LA hypertension. LA size in the apical four-chamber view may, therefore, provide a simple noninvasive assessment of the degree of LV diastolic dysfunction.

Adult↗
PubMedDate not supplied

Metastatic breast carcinoma mimicking primary thyroid neoplasm in young women.

OBJECTIVE: To highlight awareness of the potential for breast carcinoma to manifest as a thyroid lesion. METHODS: We present two case reports of young women with thyroid nodules and discuss diagnostic techniques and treatment strategies. RESULTS: In two women, 32 and 38 years old, neither of whom had a history of carcinoma, thyroid nodules were suspected clinically of being primary thyroid neoplasms. In each case, histopathologic evaluation disclosed that the tumors appeared "foreign" to the thyroid and resembled infiltrating duct carcinomas of the breast. In some histologically confusing cases, immunostaining for thyroglobulin and calcitonin may prove diagnostically helpful. The usual treatment for lesions metastatic to the thyroid is surgical resection. CONCLUSION: Metastatic breast carcinomas may manifest as primary thyroid lesions, especially in women younger than age 40 years.

Journal Article↗
PubMedDate not supplied

Misdiagnosis of Munchausen syndrome by proxy: a literature review and four new cases.

The term "Munchausen's syndrome by proxy" (MSBP) was first used in the 1970s to describe a potentially lethal variant of abuse. In representative cases a mother deceives physicians into treating her child for illness that she has fabricated or induced, her motivation being to accrue the intangible benefits of the "sick role." Increased efforts to identify and protect victims have sometimes resulted in misdiagnosis of MSBP, leading authorities to remove children from the home and/or bring criminal charges against an innocent parent. The authors believe that Improved child protection can be achieved by examining "what went wrong" in cases of erroneously diagnosed MSBP. A review of more than 200 articles and books yielded seven reports of misdiagnosed MSBP in the medical/surgical, psychiatric, nursing, social work, legal, and lay literature. These isolated reports are discussed, and four new cases are presented. The paper concludes with a discussion of lessons to be learned and a table showing situations in which the risk of an erroneous diagnosis of MSBP is increased.

Child, Preschool↗