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Biomedical subjects

M D Barrett

Publications and source records attributed to M D Barrett.

15 recordsLinked to original sources

Enhanced quantum state detection efficiency through quantum information processing.

We investigate theoretically and experimentally how quantum state-detection efficiency is improved by the use of quantum information processing (QIP). Experimentally, we encode the state of one 9Be(+) ion qubit with one additional ancilla qubit. By measuring both qubits, we reduce the state-detection error in the presence of noise. The deviation from the theoretically allowed reduction is due to infidelities of the QIP operations. Applying this general scheme to more ancilla qubits suggests that error in the individual qubit measurements need not be a limit to scalable quantum computation.

Journal Article↗

Realization of quantum error correction.

Scalable quantum computation and communication require error control to protect quantum information against unavoidable noise. Quantum error correction protects information stored in two-level quantum systems (qubits) by rectifying errors with operations conditioned on the measurement outcomes. Error-correction protocols have been implemented in nuclear magnetic resonance experiments, but the inherent limitations of this technique prevent its application to quantum information processing. Here we experimentally demonstrate quantum error correction using three beryllium atomic-ion qubits confined to a linear, multi-zone trap. An encoded one-qubit state is protected against spin-flip errors by means of a three-qubit quantum error-correcting code. A primary ion qubit is prepared in an initial state, which is then encoded into an entangled state of three physical qubits (the primary and two ancilla qubits). Errors are induced simultaneously in all qubits at various rates. The encoded state is decoded back to the primary ion one-qubit state, making error information available on the ancilla ions, which are separated from the primary ion and measured. Finally, the primary qubit state is corrected on the basis of the ancillae measurement outcome. We verify error correction by comparing the corrected final state to the uncorrected state and to the initial state. In principle, the approach enables a quantum state to be maintained by means of repeated error correction, an important step towards scalable fault-tolerant quantum computation using trapped ions.

Journal Article↗

Quantum dense coding with atomic qubits.

We report the implementation of quantum dense coding on individual atomic qubits with the use of two trapped 9Be+ ions. The protocol is implemented with a complete Bell measurement that distinguishes the four operations used to encode two bits of classical information. We measure an average transmission fidelity of 0.85(1) and determine a channel capacity of 1.16(1).

Journal Article↗

Deterministic quantum teleportation of atomic qubits.

Quantum teleportation provides a means to transport quantum information efficiently from one location to another, without the physical transfer of the associated quantum-information carrier. This is achieved by using the non-local correlations of previously distributed, entangled quantum bits (qubits). Teleportation is expected to play an integral role in quantum communication and quantum computation. Previous experimental demonstrations have been implemented with optical systems that used both discrete and continuous variables, and with liquid-state nuclear magnetic resonance. Here we report unconditional teleportation of massive particle qubits using atomic (9Be+) ions confined in a segmented ion trap, which aids individual qubit addressing. We achieve an average fidelity of 78 per cent, which exceeds the fidelity of any protocol that does not use entanglement. This demonstration is also important because it incorporates most of the techniques necessary for scalable quantum information processing in an ion-trap system.

Journal Article↗

Toward Heisenberg-limited spectroscopy with multiparticle entangled states.

The precision in spectroscopy of any quantum system is fundamentally limited by the Heisenberg uncertainty relation for energy and time. For N systems, this limit requires that they be in a quantum-mechanically entangled state. We describe a scalable method of spectroscopy that can potentially take full advantage of entanglement to reach the Heisenberg limit and has the practical advantage that the spectroscopic information is transferred to states with optimal protection against readout noise. We demonstrate our method experimentally with three beryllium ions. The spectroscopic sensitivity attained is 1.45(2) times as high as that of a perfect experiment with three non-entangled particles.

Journal Article↗

Observation of spinor dynamics in optically trapped 87Rb Bose-Einstein condensates.

We measure spin mixing of F=1 and F=2 spinor condensates of 87Rb atoms confined in an optical trap. We determine the spin mixing time to be typically less than 600 ms and observe spin population oscillations. The equilibrium spin configuration in the F=1 manifold is measured for different magnetic fields and found to show ferromagnetic behavior for low field gradients. An F=2 condensate is created by microwave excitation from the F=1 manifold, and this spin-2 condensate is observed to decay exponentially with time constant 250 ms. Despite the short lifetime in the F=2 manifold, spin mixing of the condensate is observed within 50 ms.

Journal Article↗

Storage ring for neutral atoms.

We have demonstrated a storage ring for ultracold neutral atoms. Atoms with mean velocities of 1 m/s corresponding to kinetic energies of approximately 100 neV are confined to a 2 cm diameter ring by magnetic forces produced by two current-carrying wires. Up to 10(6) atoms are loaded at a time in the ring, and seven revolutions are clearly observed. Additionally, we have demonstrated multiple loading of the ring and deterministic manipulation of the longitudinal velocity distribution of the atoms using applied laser pulses. Applications of this ring include large area atom interferometers and monochromatic atomic beam generation.

Journal Article↗

All-optical formation of an atomic Bose-Einstein condensate.

We have created a Bose-Einstein condensate (BEC) of 87Rb atoms directly in an optical trap. We employ a quasielectrostatic dipole force trap formed by two crossed CO2 laser beams. Loading directly from a sub-Doppler laser-cooled cloud of atoms results in initial phase space densities of approximately 1/200. Evaporatively cooling through the BEC transition is achieved by lowering the power in the trapping beams over approximately 2 s. The resulting condensates are F = 1 spinors with 3.5x10(4) atoms distributed between the m(F) = (-1,0,1) states.

Journal Article↗

Extrinsic Fabry-Perot interferometer for measuring the stiffness of ciliary bundles on hair cells.

We have developed an extrinsic Fabry-Perot interferometer (EFPI) to measure displacements of microscopic, living organelles in the inner ear. The EFPI is an optical phase-shifted instrument that can be used to measure nanometer displacements. The instrument transmits a coherent light signal to the end of a single glass optical fiber where the measurement is made. As the coherent light reaches the end of the fiber, part of this incident signal is reflected off the internal face of the fiber end (reference reflection) and part is transmitted through the end of the fiber. This transmitted light travels a short distance and is reflected off the surface whose displacement is to be measured (the target). This sensing reflection then reenters the fiber where it interferes with the reference reflection. The resulting interference signal then travels up the same optical fiber to a detector, where it is converted into a voltage that can be read from an oscilloscope. When the target moves, the phase relation between reference and sensing reflections changes, and the detector receives a modulated signal proportional to the target movement. Reflections of as little as 1% at both the sensor tip and target surfaces produce good results with this system. We use the EFPI in conjunction with fine glass whiskers to measure the stiffness (force per unit deflection) of stereociliary bundles on hair cells of the inner ear. The forces generated are in the tenths of picoNewton range and the displacements are tens of nanometers. Here we describe the EFPI and its development as a method for measuring displacements of microscopic organelles in a fluid medium. We also report experiments to validate the accuracy of the EFPI output and preliminary measurements of ciliary bundle stiffness in the posterior semicircular canal.

Animals↗

Distinct cis-acting sequences are required for the germination and sugar responses of the cucumber isocitrate lyase gene.

Recent data have shown that distinct DNA sequence elements direct the germination and sugar responses of the cucumber (Cucumis sativus, L.) malate synthase (Ms) gene (Sarah et al. (1996) Mol. Gen. Genet., 250, 153-161). Such information is, however, lacking for the isocitrate lyase (Icl) gene which is coordinately regulated with Ms. Deletions from the 5' end of the Icl promoter were therefore created specifically to address this question. Analysis of expression in seeds of transgenic Nicotiana plumbaginifolia plants showed that whereas a promoter sequence of 2.9 kilobases (kb) produced a normal germination response, deletion to -1568 base pairs (bp) dramatically reduced this response. Examination of the sugar response employed a transgenic cucumber root system. In this case, the 2900 bp and 1568 bp promoters both gave a strong sugar response, but further deletion to -1367 bp eliminated the response. Therefore, the germination and sugar responses of the Icl gene require distinct cis-acting elements, located respectively upstream and downstream of -1568 bp. This observation is consistent with distinct signal transduction systems regulating gene expression in each case.

Cucumis sativus↗

An investigation of membrane fluidity changes during sporulation and germination of Bacillus megaterium K.M. measured by electron spin and nuclear magnetic resonance spectroscopy.

Changes in membrane and macromolecular fluidity which may accompany the differentiation processes of sporulation and germination in Bacillus megaterium K.M. are examined by electron spin and nuclear magnetic resonance spectroscopy. No change in membrane lipid fluidity is observed in isolated forespores up to stage VI. Between stage VI and release of mature spores, the ESR spectrum of doxylstearic acid spin labels becomes polycrystalline. This change in spectral fluidity is completely reversed during germination and is paralleled by the rapid release of Ca2+ from the spore. NMR studies also show that the mature spore has reduced macromolecular mobility and an increased nonexchangeable water pool compared with vegetative cells.

Bacillus megaterium↗

Utilization of 35S from radioactive methionine or sulfate in the detoxification of cyanide by rats.

Weanling rats were fed a semipurified diet based on 10% casein and 1,500 ppm potassium cyanide. The diet was supplemented with varying levels of DL-methionine and/or potassium sulfate such that all diets were iso-sulfurous except for the basal which had no additional sulfur. The animals were fed for 2 weeks after which half of the rats in all groups except the basal were used in a radioactive study. Urine was collected and analyzed for thiocyanate. Animals which received labeled methionine were more efficient in producing labeled thiocyanate than those which received labeled sodium sulfate, although the latter did contribute to the detoxification of cyanide. Increases due to additional methionine were larger for weight gain, feed consumption, and urinary and plasma thiocyanate than with supplemental sulfate.

Animals↗

Fate of orally dosed linamarin in the rat.

Wistar rats, about 100 g in weight, were dosed by stomach tube with 30 mg of pure linamarin. No intact linamarin was identified in the feces or blood but 5.65 mg was excreted in the urine along with 0.823 mg of thiocyanate ion. A 50-mg dose of linamarin was lethal to 7 of 10 rats receiving this dose.

Administration, Oral↗