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M Czosnyka

Publications and source records attributed to M Czosnyka.

At least 55 records · Page 3Linked to original sources
PubMed2002

Clinical significance of cerebral autoregulation.

OBJECTIVES: Disturbed cerebral autoregulation is believed to be associated with an unfavourable outcome following head injury. Previously, using ICP monitoring and transcranial Doppler ultrasonography, we investigated whether cerebral response to spontaneous variations in arterial pressure (ABP) or cerebral perfusion pressure (CPP) provide reliable information on cerebral autoregulatory reserve. In the present study we have correlated these methods with clinical findings. METHODS: 188 head injured sedated and ventilated patients were studied daily. Waveforms of intracranial pressure (ICP), arterial pressure and transcranial Doppler flow velocity (FV) were captured over a half to two hour periods. Time averaged mean flow velocity (FV) and CPP were resolved. The correlation coefficient indices between FV and CPP (Mx) and between ICP and ABP (PRx) were calculated over 3 minutes epochs, and averaged for each investigation. RESULTS: The relationship between indices of autoregulation and outcome (favourable-unfavourable) was significant and stronger than the association between admission GCS and outcome. With rigorously maintained CPP-oriented therapy relationship between CPP and outcome became non-significant. Mortality in patients with consistently disturbed autoregulation ranged 47%, while in patients with good autoregulation mortality was 11% (difference: p < 0.0001). CONCLUSIONS: Positive values of indices of autoregulation, expressing positive association between slow waves of CPP and blood flow velocity or ABP and ICP, indicate disturbed autoregulation. These indices correlate with unfavourable outcome following head injury and should be used to guide intensive therapy.

Blood Flow Velocity↗
PubMed2002

Asymmetry of cerebral autoregulation following head injury.

OBJECTIVES: To investigate asymmetry of cerebra autoregulation in head-injured patients with lateral brain contusions. METHODS: Sixty five patients were admitted to Addenbrooke's Hospital suffering from head injuries with mean Glasgow Coma Score 6 (range 3 to 10). The patients were paralyzed, sedated and ventilated to achieve mild hypocapnia. Intracranial pressure (ICP), arterial pressure (ABP) were monitored directly. The left and right Middle Cerebral Arteries were insonated daily and flow velocity (FV) was recorded. Correlation coefficients between slow waves in cerebral perfusion pressure (CPP) and FV were calculated for every 3 minute period. Positive value of Mx denotes a positive association between waves in FV and CPP, therefore deranged autoregulation. Zero or slightly negative value of Mx denotes a good autoregulatory capacity. In each patient all CT scans were reviewed to assess a dominant side of brain contusion and a level of brain compression. RESULTS: The side-to-side difference in FV, pulsatility indices or critical closing pressures, did not correlate with the side of contusion or midline shift. In contrary, the side-to-side difference in Mx indices were significantly (p < 0.05) worse at a side of contusion and at the side of brain expansion in patients presenting with a midline shift (p < 0.05). Of those patients who died in hospital, significantly more presented within meaningful (ABS(Mx) > 0.2) asymmetry in cerebral autoregulation (40% versus 12%; p < 0.05). CONCLUSIONS: Side-to-side difference in cerebral hemodynamic reserve of injured brain is a predictor of fatal outcome following head injury and correlates with the side of contusion or brain expansion.

Blood Flow Velocity↗
PubMed2002

Factors determining mean ICP in hydrocephalic patients with Hakim-programmable valve: implications of the parallel arrangement of the CSF outflow resistance and shunt.

OBJECTIVE: Measurement of CSF pressure is used clinically to test shunt function in vivo in hydrocephalic patients. Criteria for appropriate shunt function have never been validated. METHOD: Hakim-Programmable valve was tested in a model of CSF circulation with variable resistance to CSF outflow (from 12 to 50 mm Hg/ml/min), increased hydrodynamic compliance (> 1.5 ml/mm Hg), and constant perfusion of a rate of 0.4 ml/min, i.e. conditions typical for hydrocephalus. The main question was how the simulated CSF pressure was influenced by the shunt setting and the residual resistance to CSF outflow. RESULTS: Measured baseline CSF pressure correlated well with shunt operating pressure only when high resistance to CSF outflow (50 mm Hg/(ml/min)) was used. For the medium resistance (20 mm Hg/(ml/min)) operating pressure was strongly affected by system's absorption capacity. For low resistance (12 mm Hg/(ml/min)) operating pressure through the valve was independent on valve's settings and no fluid drainage through the valve was recorded. CONCLUSION: Patients with moderately elevated resistance to CSF outflow (12-18 mm Hg/(ml/min)) cannot possibly react to changes of the valve's settings above 100 mm H2O. Mean CSF pressure results both from shunt setting and patient's own re-absorption capacity.

Cerebrospinal Fluid Shunts↗
PubMed2002

Shunt testing in-vivo: a method based on the data from the UK shunt evaluation laboratory.

OBJECTIVES: The objective of the UK Shunt Evaluation Laboratory was to perform an independent testing of hydrodynamic performance of hydrocephalus shunts and provide systematic reviewing for neurosurgeons and patients. METHODS: Valves were tested long-term in a computer-controlled rig to evaluate their pressure-flow performance both at baseline and under conditions mimicking phenomena, which may alter CSF drainage in vivo. The operating pressures (Poperating) and hydrodynamic resistances (R) of all types of valves, currently in use in the UK, have been evaluated (Codman: Hakim-Precision, Hakim-Programmable, Uni-Shunt, Accu-flo, Holter. Medtronic PS Medical: Delta, Flow Control, Lumbo-peritoneal. NMT: Orbis-Sigma, Omni-shunt, Hakim Valve. Heyer-Schulte: In-line, Pudenz-Flushing, LowProfile. Radionics ContourFlex. Sophy Programmable). 67 patients, who had improved in the past following shunting but had recent recurrence of their clinical symptoms, were admitted to undergo a computerized infusion test through the shunt pre-chamber or Ommaya reservoir implanted prior to shunting. The criterion used to detect shunt underdrainage was an increase in ICP during constant infusion above (Poperating) + R * Infusion rate + 5 mm Hg. The validity of this formula has been confirmed in a laboratory study. RESULTS: 35 patients met the criteria for shunt underdrainage while in 24 normal drainage was demonstrated. Mean ICP achieved during the test was 24 mm Hg in patients with underdrainage versus 14 mm Hg with normally functioning shunts (p < 0.01). Out of 35 patients 25 improved and 10 were seen again to have the test repeated. In 7 patients shunt was blocked again. Only 3 patients with primarily confirmed shunt underdrainage did not improve following revisions. In 8 patients overdrainage related to body posture was confirmed using tilt-test. CONCLUSIONS: Shunt testing in-vivo is easy, clinically useful and has good prediction power (90%).

Cerebrospinal Fluid↗
PubMed2002

Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism.

OBJECTIVES: This study explores the sensitivities of multiparameter tissue gas sensors and microdialysis to variations in blood pressure, CSF drainage and to well-defined periods of ischaemia accompanying aneurysm surgery, and their predictive value for infarction. METHODS: A Neurotrend sensor [brain tissue partial pressure of oxygen (PBO2), carbon dioxide (PBCO2), brain pH (pHB) and temperature] and microdialysis catheter were inserted into the appropriate vascular territory prior to craniotomy. RESULTS: Baseline data showed a clear correlation between PBO2 and mean arterial pressure (MAP) below a threshold of 80 mmHg. PBO2 improved with CSF drainage in 20 out of 28 (Wilcoxon: P < 0.05) cases where data was available. In 26 patients the effects of temporary vascular clipping (TC) (mean duration 16 minutes) were assessed. 2 patients subsequently declared infarction in the region of the probes. PBO2 fell from a mean 3.2 (95% CI 2.4-4.1) kPa to a minimum of 1.5 (95% CI 1.0-2.0) kPa in the non-infarct group. There was a lower baseline PBO2 (mean 0.8 kPa) in the patients who infarcted. PBCO2 mirrored PBO2 changes, whereas pHB did not change significantly in either group. Microdialysis changes associated with decreased PBO2 included a delayed increase in lactate, a raised lactate/pyruvate ratio and more rarely an increased glutamate. These changes were seen in 11 patients but were not predictive of infarction. CONCLUSION: Hypotension during aneurysm surgery is associated with a low PBO2. Multiparameter sensors can be sensitive to acute ischaemia. Microdialysis shows potential in the detection of metabolic changes during tissue hypoxia.

Adult↗
PubMed2002

Laboratory testing of hydrocephalus shunts -- conclusion of the U.K. Shunt evaluation programme.

16 models of valves, currently in use in the U.K., have been tested long-term in the U.K. Shunt Evaluation Laboratory according to the protocol based on the new ISO 7197 standard. Valves tested were: Medtronic PS Medical: Delta Valve, Flow Control and Lumbo-Peritoneal Shunt, Heyer-Schulte Nero-Care: In-line, Low Profile and Pudenz Flushing Valve, Codman: Codman-Hakim Programmable, Hakim Precision, Accu-Flo, Holter, Uni-Shunt, and siphon-preventing device -- SiphonGuard, NMT: Orbis-Sigma Valve, Omni-Shunt and Hakim Valve, Sophysa: Sophy Programmable Valve, Radionics: Contour-Flex Valve. The majority of the valves had a non-physiologically low hydrodynamic resistance (with the exception of Orbis-Sigma, PS Lumbo-Peritoneal and Heyer-Schulte In-Line). This may result in overdrainage both related to posture and during nocturnal cerebral vasogenic waves. A long distal catheter increases the resistance of these valves by 100-200%. Drainage through valves without siphon-preventing mechanism is very sensitive to body posture. This may produce grossly negative intracranial pressure after implantation. A few shunts (Delta, Low Profile and Pudenz-Flushing with Anti-Siphon Devices) offer a reasonable resistance to negative outlet pressure, and hence potentially might prevent complications related to overdrainage. On the other hand, valves with siphon-preventing devices may be blocked by raised subcutaneous pressure (exception: SiphonGuard, but this device may block the drainage because of its faulty design). In most of the silicone-diaphragm valves, closing pressure varied and reached values lower than that specified by the manufacturer (exception: Heyer-Schulte Pudenz Flushing Valve). All programmable valves are susceptible to overdrainage in the upright body position. Programmed settings may be changed by external magnetic fields. Most shunts are very sensitive to the presence of small particles in the drained fluid. The behavior of a valve revealed during such testing is of immediate relevance to the surgeon and may not be adequately described in the manufacturer's product information. These results are also relevant to the assessment of shunt function in-vivo using an infusion test.

Cerebrospinal Fluid Pressure↗
PubMed2002

A laboratory model of testing shunt performance after implantation.

Constant rate infusion tests are used clinically to test shunt function in vivo in hydrocephalic patients. The criteria for appropriate shunt function have never been validated in the laboratory. Nine of the most commonly used types of hydrocephalus valves construction were selected and tested in a model of the CSF circulation incorporating increased resistance to CSF outflow [24 mmHg/(ml/min)] and decreased hydrodynamic compliance (<2 ml/mmHg), that are typical conditions in hydrocephalus. The aim was to document the pressure response to constant rate infusion of a model of CSF circulation with different valves and to define which measures are useful in shunt testing in vivo. The pressure-course of simulated CSF pressure was established and proved to be equivalent to clinical results. The baseline CSF pressure failed to correlate with shunt operating pressure for medium pressure valves (R = 0.14, p > 0.05). End-equilibrium pressure recorded during infusion correlated strongly with the opening pressure (R = 0.94, p = 0.0001) and the shunt's resistance (R = 0.86, p = 0.0026). The infusion test is able to assess shunt function. End-equilibrium pressure recorded during the test has been confirmed to correlate with the shunt's performance.

Cerebrospinal Fluid Pressure↗
PubMed2002

Should we measure cerebral blood flow in head-injured patients?

Inadequate cerebral blood flow (CBF) after head injury is an important cause of secondary ischaemic damage. Rapid identification of episodes of hypo- or hyperperfusion would allow timely intervention and would possibly improve outcome. Despite a large number of methods to estimate CBF, this concept is only marginally implemented in clinical practice. The methods to detect such episodes are limited for technical reasons, but also because the thresholds of ischaemia and hyperaemia are variable after head injury. Furthermore, we are not always able to manipulate CBF in a controlled manner. Accordingly, it is not surprising that attempts to compare a CBF-targeted strategy with another management option have failed to demonstrate a clear benefit. Methods need to be developed that allow either identification of thresholds for critically low or high CBF in individual patients, allow monitoring oxygen extraction fraction, representing circulatory reserve, or alternatively provide a measure of the volume of ischaemic or hyperaemic brain.

Brain↗
PubMed2002

Continuous monitoring of cerebrovascular autoregulation: a validation study.

BACKGROUND: Continuous monitoring of dynamic cerebral autoregulation, using a moving correlation index of cerebral perfusion pressure and mean middle cerebral artery flow velocity, may be useful in patients with severe traumatic brain injury to guide treatment, and has been shown to be of prognostic value. OBJECTIVE: To compare an index of dynamic cerebral autoregulation (Mx) with an index of static cerebral autoregulation (sRoR). METHODS: Mx was validated in a prospective comparative study against sRoR, using 83 testing sessions in 17 patients with traumatic brain injury. sRoR and Mx were calculated simultaneously during pharmacologically induced blood pressure variations. RESULTS: Mx was significantly correlated with sRoR (R = -0.78, p < 0.05). Nine patients were found to have failure of cerebral autoregulation, with an sRoR value < 50%. If an Mx value of 0.3 was used as the cut off point for failure of cerebral autoregulation, this index had 100% sensitivity and 90% specificity for demonstrating failure of autoregulation compared with the sRoR. An increase in cerebral blood flow velocity correlated significantly with Mx (R = 0.73, p < 0.05) but not with cerebral perfusion pressure (R = 0.41). CONCLUSIONS: Dynamic and static cerebral autoregulation are significantly correlated in traumatic brain injury. Cerebral autoregulation can be monitored continuously, graded, and reliably assessed using a moving correlation analysis of cerebral perfusion pressure and cerebral blood flow velocity (Mx). The Mx index can be used to monitor cerebral blood flow regulation. It is useful in traumatic brain injury because it does not require any external stimulus.

Adult↗
PubMed2001

Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension.

Bifrontal decompressive craniectomy has been used on an ad hoc basis for the treatment of post-traumatic intracranial hypertension for more than thirty years. In this observational study we report the clinical outcome and physiological effects of the procedure in a series of 26 patients with refractory intracranial hypertension treated on a protocol driven basis. Bifrontal decompressive craniectomy was associated with significant reductions in mean ICP from 37.5 to 18.1 mmHg (p = 0.003). In addition, craniectomy reduced the amplitude of ICP waves (p < 0.02) and increased compensatory reserve (p < 0.05). A favourable outcome was achieved in 69% of patients; 8% were severely disabled and 23% died. We conclude that this study provides pathophysiological evidence that bifrontal decompressive craniectomy significantly reduces posttraumatic intracranial hypertension and improves pressure dynamics. Our results support the continued use of bifrontal decompressive craniectomy in selected patients after head injury.

Adolescent↗
PubMed2001

A model of the cerebral and cerebrospinal fluid circulations to examine asymmetry in cerebrovascular reactivity.

The authors examined the steal phenomenon using a new mathematical model of cerebral blood flow and the cerebrospinal fluid circulation. In this model, the two hemispheres are connected through the circle of Willis by an anterior communicating artery (ACoA) of varying size. The right hemisphere has no cerebrovascular reactivity and the left is normally reactive. The authors studied the asymmetry of hemispheric blood flow in response to simulated changes in arterial blood pressure and carbon dioxide concentration. The hemispheric blood flow was dependent on the local regulatory capacity but not on the size of the ACoA. Flow through the ACoA and carotid artery was strongly dependent on the size of the communicating artery. A global interhemispheric "steal effect" was demonstrated to be unlikely to occur in subjects with nonstenosed carotid arteries. Vasoreactive effects on intracranial pressure had a major influence on the circulation in both hemispheres, provoking additional changes in blood flow on the nonregulating side. A method for the quantification of the crosscirculatory capacity has been proposed.

Blood Pressure↗
PubMed2001

Laboratory evaluation of the phoenix CRx diamond valve.

OBJECTIVE: To assess the long-term hydrodynamic properties of a new cerebrospinal fluid flow-regulating hydrocephalus shunt called the CRx Diamond valve (Phoenix Biomedical Corp., Valley Forge, PA). METHODS: Three samples of a Diamond valve were tested in the United Kingdom Shunt Evaluation Laboratory during a 40-day period. Tests were performed for long-term pressure-flow performance, overdrainage, susceptibility to ambient temperature changes, external pressure, reflux, presence of small particles in the reagent, mechanical durability, and magnetic resonance imaging compatibility. RESULTS: Tests demonstrated that the Diamond valve stabilized flow within the range of 0.36 to 0.62 ml/min when pressure varied from 14 to 23 mm Hg. Hydrodynamic resistance demonstrated pressure-dependent variability from 20 to 78 mm Hg/(ml/min). The time drift of hydrodynamic parameters was significant (P < 0.001). The valve was insensitive to changes in temperature, external pressure, rapid fluctuations of differential pressure, small particles in fluid, and reflux. CONCLUSION: The Diamond valve demonstrated the intended variable resistance, which increased as the pressure increased. This property may help it limit overdrainage related to body posture as well as nocturnal vasogenic waves. Flow through the valve stabilizes within a wide range, which may contribute to the prevention of excessive pressure buildup after implantation. However, shunt placement should be avoided in patients who present with normal baseline intracranial pressure but an increased incidence of high vasogenic intracranial pressure waves.

Cerebrospinal Fluid Shunts↗
PubMed2001

Cerebral venous blood outflow: a theoretical model based on laboratory simulation.

OBJECTIVE: The cerebrovascular bed and cerebrospinal fluid circulation have been modeled extensively except for the cerebral venous outflow, which is the object of this study. METHODS: A hydraulic experiment was designed for perfusion of a collapsible tube in a pressurized chamber to simulate the venous outflow from the cranial cavity. CONCEPT: The laboratory measurements demonstrate that the majority of change in venous flow can be attributed to either inflow pressure when the outflow is open, or the upstream transmural pressure when outflow is collapsed. On this basis, we propose a mathematical model for pressure distribution along the venous outflow pathway depending on cerebral blood flow and intracranial pressure. The model explains the physiological strong coupling between intracranial pressure and venous pressure in the bridging veins, and we discuss the limits of applicability of the Starling resistor formula to the venous flow rates. The model provides a complementary explanation for ventricular collapse and origin of subdural hematomas resulting from overshunting in hydrocephalus. The noncontinuous pressure flow characteristic of the venous outflow is pinpointed as a possible source of the spontaneous generation of intracranial slow waves. CONCLUSION: A new conceptual mathematical model can be used to explain the relationship between pressures and flow at the venous outflow from the cranium.

Blood Flow Velocity↗
PubMed2001

Preliminary experience of the estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography.

OBJECTIVE: The direct calculation of cerebral perfusion pressure (CPP) as the difference between mean arterial pressure and intracranial pressure (ICP) produces a number which does not always adequately describe conditions for brain perfusion. A non-invasive method of CPP measurement has previously been reported based on waveform analysis of blood flow velocity measured in the middle cerebral artery (MCA) by transcranial Doppler. This study describes the results of clinical tests of the prototype bilateral transcranial Doppler based apparatus for non-invasive CPP measurement (nCPP). METHODS: Twenty five consecutive, paralysed, sedated, and ventilated patients with head injury were studied. Intracranial pressure (ICP) and arterial blood pressure (ABP) were monitored continuously. The left and right MCAs were insonated daily (108 measurements) using a purpose built transcranial Doppler monitor (Neuro Q(TM), Deltex Ltd, Chichester, UK) with software capable of the non-invasive estimation of CPP. Time averaged values of mean and diastolic flow velocities (FVm, FVd) and ABP were calculated. nCPP was then computed as: ABPxFVd/FVm+14. RESULTS: The absolute difference between real CPP and nCPP (daily averages) was less than 10 mm Hg in 89% of measurements and less than 13 mm Hg in 92% of measurements. The 95% confidence range for predictors was no wider than +/-12 mm Hg (n=25) for the CPP, varying from 70 to 95 mm Hg. The absolute value of side to side differences in nCPP was significantly greater (p<0.05) when CT based evidence of brain swelling was present and was also positively correlated (p<0.05) with mean ICP. CONCLUSION: The device is of potential benefit for intermittent or continuous monitoring of brain perfusion pressure in situations where the direct measurement is not available or its reliability is in question.

Adolescent↗
PubMed2001

Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus.

OBJECT: The dynamics of both drainage and storage capacity become altered during the sequential pathological processes that lead to hydrocephalus. Cerebrospinal fluid (CSF) formation and drainage rate have been reported to be age dependent. The aim of this study was to investigate whether CSF compensatory parameters are dependent on age in patients who have symptoms of hydrocephalus and apparently normal intracranial pressure (ICP). METHODS: Forty-six patients who presented with ventriculomegaly, the clinical symptoms of hydrocephalus, and normal ICPs underwent a computerized CSF infusion test. Parameters used to describe CSF compensation were calculated and correlated with the age of each patient. The mean ICPs were found to be independent of the age of the patient. Resistance to CSF outflow (Rcsf), however, demonstrated a nonlinear increase with advancing age (r = -0.57; p < 0.0001) and was associated with a decrease in the CSF production rate, which also occurred with increasing age (r = 0.49; p < 0.002). Both the pulse amplitude of the ICP waveform and the slope of the amplitude-ICP regression line increased significantly with advancing age (r = 0.39; p < 0.01 and r = 0.43, p < 0.004, respectively). The nonlinear increase in the elastance coefficient indicated increasing brain stiffness, which acompanies older ages (r = -0.31; p < 0.04). CONCLUSIONS: In a study of patients with symptoms of hydrocephalus, but normal ICPs, the increase in Rcsf and decrease in CSF production were most pronounced in patients who were older than 56 years of age. This relationship was more significant than previously suggested.

Adaptation, Physiological↗