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Biomedical subjects

M Czarnecki

Publications and source records attributed to M Czarnecki.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Humoral and cellular immune response in psoriasis].

Several immunological reactions (immunoglobulin levels in the blood serum, lymphocytic stimulation, migration of leucocytes etc.) were examined in the blood serum of psoriatics before and after treatment and compared with control. Abnormal reactions were even seen in psoriatics after successful treatment. As far as these data reveal, psoriasis is a systemic disorder.

Adolescent↗
PubMedDate not supplied

[Production of superoxide free radicals by peripheral blood leukocytes in patients with psoriasis treated by the Re-PUVA-C method].

The investigations were carried out in 20 patients with severe forms of psoriasis, and in 18 healthy subjects. The generation of free superoxide radicals by polymorphonuclear leukocytes of peripheral blood was evaluated by Bellavite et al. (1983) method by use superoxide dismutase of Sigma firm. The obtained results may confirm alterations in PMNL functions in patients with psoriasis observed by many authors. It may confirm the probability of damage of membrane structures and alterations in their bactericidal functions.

Adult↗
PubMedDate not supplied

[Evaluation of metabolic efficiency of the liver in patients with psoriasis by the antipyrine test].

In 47 patients with generalized psoriasis vulgaris and 23 healthy subjects the effectiveness of the hepatic metabolism reflected by drug biotransformation was assessed with the antipyrine elimination test. In the group of psoriatic patients there were 25 men and 22 women and in the control group--age-matched 12 men and 11 women. The half-time of antipyrine was longer and the clearance index was lower in the patients than those in the control group. The differences were statistically significant. After 2 weeks of PUVA or SUP-therapy the differences were more significant. The findings indicate an impairment of the liver metabolic effectiveness reflected by drug biotransformation in psoriatic patients.

Adult↗
PubMedDate not supplied

[Lysozyme activity in the blood serum and lysosomes and lysosomal supernatant of neutrophils in patients with psoriasis treated by the PUVA method].

The determinations of the activity of lysozyme in the serum, lysosomes and lysosomal supernatant of neutrophil granulocytes were done in 33 patients with generalized psoriasis and in 19 healthy controls. A decrease of lysozyme activity was demonstrated in the serum, lysosomes and lysosomal supernatant in the patients. During treatment by the PUVA method this activity rose gradually above the values in the control group. Systematic determination of lysozyme activity may help in monitoring of treatment progress.

Adult↗