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Biomedical subjects

M Crawford

Publications and source records attributed to M Crawford.

At least 145 records · Page 8Linked to original sources
PubMed1988

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells.

Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariably develop lymphomas, 90% succumbing in the first 5 mo of life. The tumors typically presented as rapidly progressive lymphadenopathy with thymic involvement and were highly malignant by transplantation assay. Morphologically, they were lymphoblastic lymphomas, usually accompanied by lymphoid leukemia and granulocytosis, and were distinct from the tumors that arose much later in 37% of nontransgenic mice of the same (C57BL/6 x SJL)F2 genetic background. Cell-surface markers on 31 E mu-myc tumors identified 52% as pre-B lymphomas, 29% as mixed pre-B and B lymphomas, and 19% as B lymphomas. The tumors appeared to arise at random from a population of pre-B cells expanded by constitutive expression of the myc transgene. A majority of the animals initiated malignancy at the rate of 17% per week. The rate at which the cycling, benign pre-B cells spontaneously convert to malignancy was estimated to about 10(-10) per cell per generation. A transient leukocytosis identified in young E mu-myc mice was developed into a rapid assay for inheritance of the transgene.

Animals↗
PubMed1988

The effect of droperidol on fentanyl-influenced gastric emptying in man.

The effect of droperidol on gastric emptying was determined from the rate of paracetamol absorption in seven healthy adult volunteers who received fentanyl, each acting as his/her own control. On each occasion the subjects were given droperidol 2.5 mg or normal saline (placebo) i.v. in double-blind fashion. On both occasions, 20 and 50 min later a dose of 0.0015 mg kg-1 fentanyl was given. Ten minutes after the first fentanyl dose, the subjects ingested 20 mg kg-1 paracetamol with 200 ml of water. Our findings demonstrate that droperidol was not able to accelerate gastric emptying in subjects receiving subsequent small doses of fentanyl. Furthermore, the delayed absorption pattern of paracetamol on both occasions suggests that gastric emptying is retarded with or without droperidol.

Adult↗
PubMed1988

"Tech hints".

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Letter↗