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Biomedical subjects

M Crawford

Publications and source records attributed to M Crawford.

At least 181 records · Page 10Linked to original sources
PubMed1985

Gc subtypes identified by isoelectric focusing in baboons (Papio hamadryas).

Phenotyping for Gc variants by conventional electrophoresis in 835 Papio hamadryas baboons demonstrated a monomorphic population. Gc subtyping by polyacrylamide IEF gels, pH 4-6, on 394 of these baboons revealed the existence of two common alleles which we named Gc1Papio and Gc2Papio. Pedigree data confirmed the inheritance of a single locus, two allele system and the observed gene frequencies were 0.593 for Gc1Papio and 0.407 for Gc2Papio.

Alleles↗
PubMed1985

Prominent ears: a follow-up study.

Following a minimum observation time of 14 months, 74 patients having undergone surgical correction of prominent ears were re-examined. The applied surgical technique was modified from Stenström and Warrer utilizing the scoring technique and subcutaneous mattress chrome catgut sutures for fixation. Satisfactory results were achieved in more than 95 per cent of the patients, when assessed by both the patient and the surgeon. Only few complications were revealed.

Adolescent↗
PubMed1985

High-frequency small-volume ventilation in anesthetized humans.

Pulmonary gas exchange during conventional mechanical ventilation (CMV) (tidal volume 10 ml/kg, rate 8-10 breaths/min) was compared with that during high-frequency small-volume ventilation (HFV) in 67 patients undergoing anesthesia for various surgical procedures. HFV was studied at oscillation frequencies ranging from 3 to 18 Hz with stroke volumes of 0.8 to 2.2 ml/kg. Adequate pulmonary gas exchange was achieved with CMV and HFV, and the efficiency of oxygenation, that is, (A-a)DO2, was similar in the two conditions. During HFV, the lung volume was higher than during CMV in most patients. Muscle paralysis did not significantly change either PaCO2 or PaO2. In general, increasing fresh gas flow into the HFV system above approximately 10 1/min resulted in little reduction in PaCO2, but reduction of fresh gas flow below approximately 6 1/min increased PaCO2 progressively. Currently, we do not recommend HFV at 12-18 Hz for routine use during anesthesia for orthopedic or abdominal surgery.

Adult↗
PubMed1985

Hydraulic estimation of stenotic orifice area: a correction of the Gorlin formula.

To determine the source of errors in the Gorlin formula for estimating stenotic valvular orifice area, we used a pulsatile flow model that emulated left ventricular and aortic pressures and flow and allowed control of ventricular outflow orifice area. After comparing orifice areas calculated by the Gorlin formula with actual orifice areas, the Gorlin formula constant (k) was found to be highly correlated with the square root of the mean transvalvular gradient (r = .95). A new formula was derived empirically and predicted areas more accurately and with smaller standard errors than the Gorlin formula in the model (r = .98, SEE = 0.11 and r = .87, SEE = 0.28, respectively) in a series of 19 patients with Hancock porcine xenograft valves (r = .89, SEE = 0.07 and r = .60, SEE = 0.12, respectively) and in the original series of patients reported by Gorlin and Gorlin in proposing the Gorlin formula (r = .93, SEE = 0.11 and r = .91, SEE = 0.12, respectively).

Aortic Valve Stenosis↗
PubMed1981

Renal function and laboratory safety parameters after two weeks' administration of fluproquazone to man.

When 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) was given for 14 days (100 mg t.i.d.) to six healthy male volunteers, it produced no clinically relevant effects upon the subjects' renal function, urine microscopic findings, blood coagulation status, or upon their general well-being as shown by a range of laboratory safety tests including haematological profile and blood and urine biochemistry. Minor and transient side effects mainly affecting the gastrointestinal system were seen in four subjects.

Adult↗
PubMed1981

Effects of fluproquazone on platelet aggregation in man.

Turbidimetric investigations on platelets from healthy volunteers have shown inhibitory effects of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) and acetylsalicylic acid (ASA) on both the extent and the velocity of aggregation induced by collagen. The threshold concentration of arachidonic acid needed to induce aggregation was also raised after fluproquazone was given to the donors. Whereas the inhibitory effects of fluproquazone disappear within 24 h, the qualitatively similar effects of ASA are much longer lasting (72--96 h). There is no evidence for enhancement of the effects of fluproquazone following four days of administration (100 mg t.i.d.).

Adult↗