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Biomedical subjects

M Cowan

Publications and source records attributed to M Cowan.

54 records · Page 3Linked to original sources
PubMed1986

Echocardiographic left ventricular mass and physical activity: quantification of the relation in spinal cord injured and apparently healthy active men.

To assess the relation of echocardiographic left ventricular (LV) mass to reported physical activity, 2 groups of subjects with widely different physical activity levels were evaluated: 50 men with spinal cord injuries and 166 apparently healthy, active men. Multivariate analysis revealed that reported physical activity was a significant independent predictor of LV mass index (LV mass/body surface area) in both injured patients and healthy, active subjects after controlling for age and blood pressure. The relation between LV mass index and physical activity (linear regression) was similar for both groups; LV mass index = 0.00321 (physical activity) + 82.8 and LV mass index = 0.00335 (physical activity) +88.4 for patients and healthy active subjects, respectively. These results suggest that physical activity as assessed by self-report is associated with echocardiographically detectable differences in LV mass in groups with widely divergent physical activity levels. In addition, for each of these groups 1,000 kcal/week of physical activity apparently results in a change of approximately 3 g/m2 in LV mass index. This information may have practical use for correction of LV mass for the effects of physical activity.

Adult↗
PubMed1985

Antibodies to AIDS-associated retrovirus distinguish between pediatric primary and acquired immunodeficiency diseases.

Antibody to acquired immunodeficiency syndrome (AIDS)-associated retroviruses (ARVs) was investigated in 68 pediatric patients with abnormalities of T-cell and/or B-cell immunity. All except seven patients conformed to a specific World Health Organization classification for immunodeficiency disease. These seven patients had polyclonal hypergammaglobulinemia and T-cell immunodeficiency. Six of the seven patients had antibody to ARV and had risk factors associated with AIDS. The one patient without antiviral antibody had no AIDS risk factors. No antibody was detected in 61 patients with other primary immunodeficiency disorders. We conclude that ARV first appeared in our population of immunodeficient pediatric patients prior to 1978, is associated with a distinctive immunologic phenotype consisting of polyclonal hypergammaglobulinemia and T-cell immunodeficiency, and does not appear as an opportunistic infection in other immunodeficiency disorders. Detection of the retrovirus associated with AIDS is of value in identifying infants and children who may have unique medical and social problems that occur with AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Acquired immune dysfunction in homosexual men: immunologic profiles.

Homosexual men with Kaposi sarcoma, lymphadenopathy syndrome, opportunistic infection, and nonhomosexual traditional Kaposi sarcoma were evaluated for B cell, T cell, and complement immunity and compared to normal controls and homosexual controls. No significant immunologic abnormalities were found in the traditional Kaposi group. All homosexual groups, including the homosexual controls, had a significant decrease in the helper/suppressor cell ratio. Functional abnormalities of T-cell immunity were observed in the homosexual Kaposi sarcoma, lymphadenopathy syndrome, and opportunistic infection groups. Significant elevations of IgG, IgM, IgA, and IgE were found in the lymphadenopathy group, while only IgG and IgA were elevated in the Kaposi sarcoma group. C3, C4, and immune complexes were normal, while total hemolytic complement activity was increased in the Kaposi sarcoma and lymphadenopathy syndrome groups.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Developmental training by parents of the very young child with potential handicap.

Fifteen children aged 9 to 15 months, who were on the observation register of a city, and considered to be showing signs of delayed development, were studied over a 3-month period. Following assessment, the parents were shown ways in which they could train their children appropriate to their development levels, in separate fields of locomotion, social development, language, and hand-eye coordination. Eight out of 13 children with delay showed significant improvement in general quotients of development over the 3 months. This occurred in 5 out of 7 children with no signs of neurological abnormality at the time of the study, and in 3 out of 6 children with signs of neurological disorder. Two children without delay showed no significant improvement. Parents' reactions are discussed, and a description is given of the way in which this project was designed, suggesting implications for future implications for future Community Health services.

Child Development↗
PubMedDate not supplied

Case studies of the ischemic foot and management with bypass surgery.

Four case studies are presented to demonstrate the interdisciplinary approach used in management of the ischemic foot. In each case, bypass surgery was used to increase vascularity to the affected limb. This surgical aggressive approach, medical management combined with local wound care, provided a satisfying clinical outcome.

Aged↗
PubMedDate not supplied

Dirty linen.

Explore the source record for details and available documents.

Cross Infection↗
PubMedDate not supplied

Measurement of recovery from myocardial infarction using heart rate variability and psychological outcomes.

This pilot study was designed to describe heart rate variability (HRV), anxiety, anger, denial, and depression during the first 4 days and 6 months after acute myocardial infarction (AMI). The sample was composed of 21 post-AMI males aged 40 to 83. State anxiety was elevated early. At 6 months it had significantly decreased. The nonpower measure of HRV, the Kleiger global standard deviation, was decreased to a mean score of 86 (SD = 29) msec during AMI and was 117 (SD = 30) msec at 6 months. Although there were no significant correlations between HRV, psychological response, age, and education, there were moderate correlations between HRV and state anger (r = .33), denial (r = .35), and education (r = .45). HRV, as measured by the power spectral density function of an autoregressive model, demonstrated an increased peak across the band of frequency associated with the high-frequency components of the parasympathetic system and a decreased peak across the band associated with the low-frequency components of the sympathetic system at 6 months as compared to the AMI period.

Adult↗