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Biomedical subjects

M Covic

Publications and source records attributed to M Covic.

68 records · Page 4Linked to original sources
PubMedDate not supplied

Genetic damage induced by an occupational complex and prolonged chemical exposure.

Some results of a study on the clastogenicity of chemicals in vivo are reported. The chromosomes in lymphocytes from whole blood cultures were studied in 60 subjects permanently exposed for about 6 years to several occupational chemicals acting concomitantly, and in 5 controls. The exposed subjects showed an increase in the rate of chromosomal aberrations as compared to controls.

Chromosome Aberrations↗
PubMedDate not supplied

[The progression factors in autosomal dominant polycystic disease].

This study was performed to evaluate prognostic factors in ADPKD progression to ERSF. Previously reported negative factors (male gender, age, hypertension, palpable kidneys and UTI) as well as the extra-renal presence of cysts and proteinuria, were analysed in a group of 45 ADPKD patients (Male/Female, 25/20; Age = 40.1 +/- 19.7 yrs, range 21-69). Palpable kidneys were associated with higher serum creatinine values (955 +/- 689 vs 743 +/- 504 umol/l, p < 0.001) but not with a greater prevalence of renal failure. Renal failure (100% vs 60%), higher creatinine values (981 +/- 495 vs 778 +/- 654 umol/l) and hypertension (50% vs 18%) were related to a higher prevalence of extra-renal cysts (p < 0.05). Older patients (> 40 years) had a greater prevalence of renal failure (96% vs 32%, p < 0.001). Also, subjects with palpable kidneys, and those with extra-renal cysts, were significantly older (52.8 +/- 10.3 vs 30.5 +/- 20.6 yrs, p < 0.025; and 42.1 +/- 21.9 vs 38.1 +/- 18.2 yrs, p < 0.025). Patients with renal failure and those with extra-renal cysts had a greater prevalence of proteinuria (65% vs 0%, p < 0.001; and 100% vs 24%, p < 0.001). No correlation was seen for male gender, hypertension or UTI with any known complications of ADPKD. The extrarenal presence of cysts, older age, proteinuria and palpable kidneys were associated with a worse renal outcome, but for this Romanian population we can't confirm previous reports suggesting a role for male gender and early onset of disease.

Adult↗
PubMedDate not supplied

[The relationships of rapidly progressive glomerulonephritis (RPGN), crescentic glomerulonephritis and vasculitis: the clinical, histopathological and therapeutic considerations].

Rapidly progressive glomerulonephritis (RPGN) is a rare but severe condition, with a particular poor outcome in the absence of aggressive therapy. Our study describes all RPGN consecutive cases treated during the 1994-1995 period, with special interest in revealing negative prognostic features at presentation and the optimum therapeutic strategy. 14 (20% of all ARF for the same period) cases were classified as RPGN. Although rare (30%), extrarenal symptoms were related with a more unfavourable course. Creatinine clearance at presentation was not a reliable prognostic factor in our study. ANCA was found in 86% of our patients (p-ANCA/c-ANCA = 2/1), and therapeutic success was associated with ANCA disappearance. Crescentic glomerulonephritis was seen in 93% of all cases 77% of which were type III, pauciimune, ANCA positive. Vasculitic lesions and fibrous crescents, but not % of glomerular circumference or % of affected glomeruli were also related with a poor prognosis. Only 43% of our RPGN cases survived with a normal renal function. i.v. metil-prednisolone (at presentation, as soon as possible) followed by i.v. cyclophosphamide up to six months was the best therapeutic regimen, with no important side-effects.

Acute Disease↗
PubMedDate not supplied

[The determination of the prevalence of antibodies to the hepatitis C virus (anti-HCV) and of the serum levels of C-reactive protein in chronic dialysis patients].

UNLABELLED: The chronic dialysis patients are subject at risk for the hepatitis C virus (HCV) infection. Among these subjects, the hemodialysis-induced and increased synthesis of IL6 which suggest an acute phase response. 58 chronic dialysis patients were tested for presence of anti-HCV antibodies; 45 (77.58%) presented this serological marker. None of the 15 nursing subjects tested presented anti-HCV. C reactive protein (CRP) levels were measured in 41 patients. Elevated levels were detected in 5 (12.19%) patients. Such a high prevalence of anti-HCV reveals the hemodialysis to be a risk factor for the HCV infection. CRP levels measured by Mancini method lack the sensitivity for a more accurate interpretation. CONCLUSION: 1. the high anti-HCV prevalence among hemodialysis patients emphasize the opportunity of blood testing also for serological markers in ante-transfusional screening. 2. the immunoturbidimetry method for CRP testing may be a better assay in order to establish significant correlations.

Adult↗