Biomedical subjects
Publications and source records attributed to M Cousineau.
This article briefly traces the history of employees' help programs and describes their activities and the modalities of their organization. It illustrates the impact such programs have on the mental health of an entreprise and their employees.
Oral contraceptives inhibited the growth of calcium oxalate crystals in female urine, and the growth rate inhibition depended on the dose of ethinyl-oestradiol in the oral contraceptive agent. The results suggest that the crystallization kinetics of calcium oxalate in urine could be under the control of oestrogenic hormones by an unidentified mechanism.
A method is described for the growth of calcium oxalate dihydrate in normal urine. Soluble chlorophyllin, at a concentration of 20 microgram/ml inhibited the crystallisation and the growth kinetics of the dihydrate crystals. The inhibitory capacity of chlorophyllin was compared with previous results. Data obtained suggest that the food and drug colourant chlorophyllin might be useful in the treatment of calcium oxalate stone disease.
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We induced the deposition of calcium oxalate crystals in rat kidney by intraperitoneal administration of 4-hydroxy-L-proline or sodium oxalate and studied the amounts and size distribution characteristics of the deposited crystals. Intravenous administration of sodium copper chlorophyllin inhibited the deposition and growth of calcium oxalate crystals induced by 4-hydroxy-L-proline or sodium oxalate. This finding may be of importance in calcium oxalate urolithiasis.
We studied the growth of calcium oxalate dihydrate crystals (weddellite) in simulated urine and its transformation into the more stable monohydrate (whewellite). Sodium copper chlorophyllin in a concentration of 100 microgram per ml inhibited the growth of calcium oxalate dihydrate crystals in simulated urine. The size distribution parameters of the dihydrate crystals in the presence and absence of chlorophyllin suggest that soluble chlorophyllin could be of clinical significance in calcium oxalate urolithiasis.
We have observed that certain antisera to HLA antigens suppress the in vitro proliferation of lymphoblastoid cell lines. An antiserum to HLA-B8 demonstrated suppressor activity associated with the presence of B8 antigen on the target LCLs; this activity was removed by absorption with platelets or with B8-positive LCLs. An antiserum to HLA-DRw7 suppressed proliferation of all six DRw7-positive LCLs and none of 12 DRw7-negative LCLs; this activity was removed by absorptions with three DRw7-positive LCLs, each representing a different HLA-D allele (i.e. Dw7, 10 and 11); it could not be removed by triple serial absorptions with platelets from multiple-donor pools. These experiments indicate that the suppressor activity of this serum is specifically associated with antibodies to DRw7. Our model of LCL growth suppression by HLA antisera is easily manipulated and provides a definitive tool for further characterizing HLA antigens and antisera in a complement-independent system.
Physiological and psychological parameters of 20 survivors of penetrating wounds of the heart were examined 7 to 52 months after recovery. All survivors had cardiac complaints. The psychological parameters for hypochondriasis, compulsiveness, and internalization were much greater in the patients than in control subjects but were similar to those in victims of violent major abdominal trauma. Physiological abnormalities were present in 19, although no particular pattern or abnormality could be related with certainty to the type of wound, operative procedure, or postoperative course. One recovered and re-employed victim required late surgical repair of a traumatic ventricular septal defect and ventricular diverticulum. Although functional work capacity measured by stress testing was normal in 90 percent, only eight survivors resumed employment. Complete rehabilitation was impaired by a residual traumatic neurosis. Management goals for patients with penetrating cardiac wounds should be broadened to include prevention of psychological disabilities.
A growing percentage of Medicaid patients are receiving medical care within a managed care system. This policy change has raised concerns about whether safety-net providers can maintain their share of Medi-Cal (California Medicaid) patients. From 1995 to 1997 several of California's counties implemented mandatory Medi-Cal managed care. The majority of California's safety-net primary care clinics experienced a decline in the percentage of their patients insured by Medi-Cal. However, after the overall decline in the number of Medi-Cal beneficiaries was controlled for, the increased penetration of Medi-Cal managed care in a county was not independently associated with a decline in clinics' share of Medi-Cal patients. Despite this fact, it may become increasingly difficult for clinics to maintain their current level of services with declining Medi-Cal enrollment and other anticipated reforms in their funding.