[Behavior of gamma-glutamyl transpeptidase (gamma GT) in the serum of chronic alcoholic patients].
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Adolescent↗
Biomedical subjects
M Cossio
Publications and source records attributed to M Cossio.
[Nosography of neuroses. 7. Relation between neurotic syndromes and the spasmophilic syndrome].
The investigators have examined the literature dealing with the psychic symptomatology that generally accompanies tetanic and spasmophilic phenomena, particularly the psychic and characterological substratum of patients affected by such symptoms. By focusing their inquiry on the spasmophilic symptoms displayed by neurotic patients, rather than on the psychic disturbances of patients with spasmophilic symptoms, the following considerations emerge: The widely held view that psychic disturbances in spasmophilic patients can be fitted into the classic picture of asthenic, anxious or depressive disorders is not tenable. The erethistic syndrome with its characteristics of generalized irritability and hyperexcitability, described by us in 1966, is the one most frequently exhibiting spasmophilic symptoms. Therefore, nervous erethism encompasses the most important characteristics of erethistic neurosis as well as of spasmophilia. A connection between the psychological and biological aspects of neurotic conditions is again foreseeable, especially in the light of recent discoveries on normocalcemic spasmophilia. In conclusion, it is intriguing to speculate that the neuropsychic disturbances of spasmophilia fit into the larger conception of nervous erethism and that the psychic and somatic phenomena of both have the same biological origin.
Anxiety Disorders↗
[Extreme degree familial hypobetalipoproteinemia caused by hypothetic double heterozygosity in a subject with severe mental deficiency].
We described the case of an adult male patient, seriously mentally deficient, hospitalised in Psychiatric Hospital for a period of many years, suffering from a familial hypobetalipoproteinemia with extremely low levels of plasmatic betalipoproteins. The patient has been followed and tested several times over a period of six years. Numerous members of his family, which is part of a restricted ethnic nucleus in a locality (Iolo) of the Comune of Prato in the Provincia of Florence, were examined and tested too. Consanguinity between his parents is not demonstrable. The diagnosis of homozygous hypobetalipoproteinemia is discarded, but it does not seem that the heterozygous one is to be accepted as weel. On the ground of the existence of two syndromes which are quite unlike each other, but both explainable as form of familial heterozygous hypobetalipoproteinemia, one of them present in his father, the other one in his mother and in the maternal relatives as in the patient's brother respectively, a hypothesis of a double heterozygosis could be formulated. Extant is the support of the recent literature data, depending on them the possibility of making the hypothesis of a multiplicity of the genes regulating the apolipoprotein B synthesis. We do not exclude that the peculiarity of the event of a double heterozygosis can also be directly responsible of the patient's serious mental deficiency, being at the same time more supportable the hypothesis of a encephalopathy in his early childhood.
Adult↗
[Recited depression].
Several subjects who tell their depression and play a part of it in front of the doctor without being really depressed are reported. Some of them try to hide the symptoms (irritability or erethism, ceremonials of obsessive neurosis, shunning of phobia) which, in their opinion, might be detrimental to their reputation. Others neglect to describe some of the symptoms of their polymorphous clinical picture only underlining the depressive signs. Some others play a part of depression because they have believed to recognize themselves in persons presented by mass media, because it seems to them a duty to show an adequate depression in case of mournful event, or because they "convert" their problem into a depression. Some others use depression as a blackmail, or to obtain an advantage from doctor's conviction about their illness. The reason for the high frequency of similar cases in the present time are examined: the scientific divulgation and the acceptance of depression by the modern society are among the most important ones. The peculiar semantic vicissitudes of the word depression are also reviewed. A widening of the boundaries of depression has contributed to an increase in the number of the cases. Finally, in addition to patients who are depressed without being aware of it, the authors focus the inverse possibility: patients who believed or try to make their doctor believe (playing the part of depression in front of them) that they are depressed.
Aged↗
[Nosography of the neuroses. 5. Aspects and problems of the neurotic reaction as an adaptive disorder].
The term "neurosis", although is no longer used in the recent American classification, is still considered valid and firmly established in our learning even with its etymological and semantic inexactitudes. So in this 5th coordinated and systematical study on the nosography of neurosis the Authors observe its less known and less described aspects in literature, such as short-dated neurosis forms with acute course. These situations of acute neurosis can be explained as unspecific answers to stress situations, that is to say as reactions to conscious or removed biological and psychological events. They are disorders of adaptation with a single pathogenetical mechanism and their aspect suggests the approach to alarm-reactions for unspecific stressors. This neurotic reaction of adaptation, conditioned by the subject's cognitive interpretation, has the characteristics of an exaggerated and disorderly alarm-reaction with particular polymorphism of its symptomatology. The Authors elaborate a model of the symptomatology and they examine the differential diagnosis of these reactions. Regarding the evolution and the course of this disorders they assert that the prognosis is good, but in some cases there may be the passage to a form of structured neurosis or the evolution to a depressive syndrome; they interpret this as a decompensation due to the exhaustion of fitting mechanisms. At the end of the study the authors illustrate the therapy.
Adaptation, Psychological↗