Thirty-five patients with advanced cervical cancer were treated with a combination chemotherapy regimen comprising cisplatin, vinblastine, and bleomycin (PVB). Sixty-six percent of 33 evaluable patients showed objective tumor response and complete remissions were seen in six (18%) patients. The median duration of tumor response in patients with recurrent cervical cancer was 24 weeks (range 8 to 104 weeks). Multivariate analysis of pretreatment variables including prior radiotherapy did not identify patients with a higher response probability. Nausea and vomiting were usual side effects of chemotherapy and there was one definite treatment-related death. Cervical cancer is responsive to cisplatin based combination chemotherapy. The role of chemotherapy in conjunction with radiotherapy or surgery in the treatment of locally advanced cervical cancer remains to be defined.

Adult↗

PubMed1980

Noncondylomatous cervical wart virus infection.

Human papillomavirus (HPV) infections of the genital tract frequently involve cervical epithelium and produce a macroscopically flat lesion that the authors have called noncondylomatous cervical wart virus infection (NCWVI). Over a 6-month period, 92 of 7281 routine cervical smears (1.3%) and 46 of 183 colposcopically directed punch biopsies (25%) showed morphologic evidence of wart virus infection. The etiologic role of HPV was confirmed by the demonstration of virus particles in 24 of 53 cases (45%) examined by electron microscopy. The colposcopic features of NCWVI consist principally of epithelial opacity and vascular atypia, leading to frequent confusion with cervical intraepithelial neoplasia. Differences in surface contour, color, vascular patterns, and topography generally permit colposcopic differentiation. These 2 conditions sometimes coexist; whether the association is causal or casual in not presently known.

Colposcopy↗

PubMed1979

Homogeneous hetero sapiens.

Explore the source record for details and available documents.

Biological Evolution↗

PubMed1979

Microinvasive cervical cancer.

Explore the source record for details and available documents.

Colposcopy↗

PubMed1978

Sperm basic proteins in cervical carcinogenesis: Correlation with socioeconomic class.

Two types of basic protein, a histone and a protamine, were separated from single ejaculates of human sperm and a ratio between their contents in a given number of sperm established. The ratio varied widely in different males and correlated with ranking by social class: the lower the social class, the greater the proportion of protamine. Statistically similar correlations link social class with the incidence of venereal disease and the incidence of in-situ carcinoma of the cervix, both of which are epidemiological variables in squamous cervical cancer. The basic proteins of the sperm head, especially the protamines, may thus also have a role in the aetiology of squamous cervical cancer.

Carcinogens↗

PubMed1976

A hypothesis: the role of a high-risk male in the etiology of cervical carcinoma: a correlation of epidemiology and molecular biology.

Certain impressive epidemiological evidence appearing in the last few years leads to the conclusion that some males are more prone to have a spouse with squamous cancer of the cervix than others. Advances in knowledge in other fields, especially at the molecular biological level, enable speculation on reasons for this curious conclusion. These readily testable theories, together with an outline of the evidence on which they rest, form the substance of this hypothesis.

Carcinoma, Squamous Cell↗

PubMed1976

The new colposcopic terminology.

A generally acceptable scheme for the classification of colposcopic findings is critical for the more widespread acceptance of this valuable diagnostic tool. Older schemes have tended to confuse students. The scheme described in this article sets appearances against an order of events in time and place based on the biological life history of the organ. This amounts to the history of exposed columnar epithelium as it changes, by a typical or atypical process, into squamous epithelium to produce, respectively, a typical or atypical transformation zone. The former produces a homogeneous appearance, the latter a heterogeneous appearance requiring further subdivision by the use of the categories of white epithelium, blood vessel abnormalities such as punctation and mosaic and other atypical patterns, and leukoplakia. Not all of these abnormal appearances are associated with greatly altered histological appearances and, therefore, a further system of their grading is introduced. Other categories include appearances associated with overt cancer, with miscellaneous noncancerous conditions and with states in which the complete transformation zone is not viewed and, therefore, the colposcopic findings are not satisfactory. Finally, the present scheme is integrated as far as possible with older schemes.

Cervix Uteri↗

PubMed1969