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Biomedical subjects

M Cooper

Publications and source records attributed to M Cooper.

At least 325 records · Page 18Linked to original sources
PubMed1975

Demographic characteristics and trends in arteriosclerotic heart disease mortality: Sudden death and myocardial infarction.

The Baltimore Study of Sudden Death and Myocardial Infarction was a two-year project to investigate the epidemiological, clinical and pathological characteristics of sudden death and myocardial infarction in a defined population. The incidence of sudden death was much higher in men than women for both blacks and whites. Blacks and white women had a similar incidence of transmural myocardial infarction, but white men had a much higher incidence of transmural myocardial infarction than black men. White men who died suddenly had twice as many coronary thrombi at postmortem examination than black men and a greater extent of coronary artery stenosis than the other three race-sex groups. Black men had a higher prevalence of heart weights greater than 500 grams. Women who died suddenly were more often not married and smoked more cigarettes than neighborhood controls. Nine of 39 white women who died suddenly due to ASHD had a definite prior psychiatric history. The ASHD death rates have been declining in the 45 to 64 age groups, especially for white men. However, a comparison of the 1964 and 1970-72 sudden death studies in Baltimore reveals that the same percentage of ASHD deaths were sudden unwitnessed, occurred in a hospital or had a prior history of heart disease in both time periods.

Age Factors↗
PubMed1975

Arteriosclerosis of coronary arteries in sudden, unexpected deaths.

The authors graphically studied the topographic pattern and severity of coronary arteriosclerosis in arteriosclerotic heart disease (ASHD) sudden deaths using an improved technique involving in toto removal and decalcification of the main coronary tree. The study involved 171 cases of ASHD sudden death and 154 deaths from other causes. White males were the most severely affected group. The majority of the ASHD deaths had three or four major coronary vessels showing greater than 75% luminal stenosis; single-artery disease was a rare occurence. The intra- and interarterial pattern of coronary stenosis was equally severe and diffuse, with the exception of the arteries to SA and AV nodes. No small intramyocardial blood vessel disease was evident. Severe chronic coronary stenosis was associated with a high incidence of old myocardial infarction. The anatomical and pathological pattern of coronary stenosis in ASHD deaths appears to have ominous therapeutic implications.

Adult↗
PubMed1974

Erythropoietic differentiation in colonies of cells transformed by Friend virus.

Cells transformed by Friend virus in liquid suspension culture respond to low concentrations of dimethylsulfoxide by initiating hemoglobin synthesis. The kinetics of appearance of such differentiated erythroid cells is consistent with either the induction of differentiation in a uniformly susceptible population of transformed cells or selection for the growth of a distinct erythropoietic subpopulation. The dimethylsulfoxide response of individual colonies of cells transformed by Friend virus grown in semisolid medium was studied in order to distinguish between these alternatives. The data do not support a selective effect of dimethylsulfoxide on the growth of a unique erythropoietic subpopulation; they indicate, rather, that the 745A strain of cells transformed by Friend virus consists of a relatively uniform population of dimethylsulfoxide-sensitive erythropoietic cells.

Animals↗
PubMed1974

Measurement of regional lung function in the early detection of chronic obstructive pulmonary disease.

Radioisotopic regional lung function measurements using both 99mTc-labeled albumin microspheres and inhaled 133Xe were compared to measurements of total lung function in a population of 30 participants in an epidemiological study of the causative factors of obstructive pulmonary disease. Five of the 8 asymptomatic subjects who had no evidence of obstruction by the tests of total function had abnormal regional lung function measurements. The closing volume was abnormal in three of these five, suggesting the presence of small airways disease. Regional lung function was abnormal in all subjects who were symptomatic, who had a FEV1/FVC less than 75%, or who had an elevated closing volume or residual volume. The data indicate that the measurement of regional lung function may be a highly sensitive test for the early diagnosis of chronic obstructive pulmonary disease.

Adolescent↗