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Biomedical subjects

M Constantinescu

Publications and source records attributed to M Constantinescu.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Contributions to the study of the etiology of serofibrinous pleurisy in Romania, under the present epidemiological conditions. Evaluation of the etiological role of viruses.

A number of 56 serofibrinous pleurisy cases were subjected to several usual diagnostic tests, as well as to virological investigations. Significant rises in serum antibody titers to different viruses were recorded in 25 cases; the presence of virus antigens in cells from the pleural fluid could be visualized by immunofluorescence in 11 patients. In many cases there was evidence suggesting multiple viral infection. The contribution of various investigation methods to differential diagnosis is discussed and the etiological patterns specific to different territories are outlined.

Antibodies, Viral↗
PubMedDate not supplied

[Clinico-epidemiological considerations on an outbreak of Q fever in the Argeş region].

The present paper reports on a Q fever episode, including 45 subjects (caretakers, technicians, workers building stables) in a zootechnical cooperative in the district of Argeş. In the new unit milch and reproduction cows were brought from various parts of the district. None of the animals showed visible signs of the disease. No cases of Q fever had been reported in man or animals in the locality until then. The episode had an explosive character, the outbreak occurring during the calving season. The diagnosis was established clinically, epidemiologically, radiologically and serologically.

Animal Husbandry↗
PubMedDate not supplied

Behaviour of uricemia in hyperlipoproteinemic subjects.

When compared to values obtained in 40 normalweight normolipemic healthy control subjects, serum uric acid levels were found to be significantly increased in 68 subjects with type II-b and especially in 68 subjects with type IV hyperlipoproteinemia. A much lesser increase of uricemia occurred in 22 patients with type II-a. A significant positive correlation between uricemia and serum triglyceride level could be demonstrated but no such correlation was found with serum cholesterol. Overweight and hypertensive hyperlipemic subjects were presenting higher levels of serum uric acid than normalweight normotensive ones. On the other hand, clinical atherosclerosis and diabetes mellitus had no additive effects upon uricemia in hyperlipoproteinemic patients. It is suggested that hyperinsulinism and accelerated turnover of lipoproteins, often encountered in obese and hypertriglyceridemic subjects, might lead to an enhanced synthesis of purines and subsequently increased production of uric acid.

Adult↗
PubMedDate not supplied

Serological diagnosis of chronic viral hepatitis.

Chronic viral hepatitis must be distinguished from other chronic liver disorders. The clinical picture associated with typical biochemical findings provides no definite information about the causative agent. An important factor, both for the patient and for the individuals in contact with him, is the evaluation of his infectivity. From 172 chronic hepatitis disorders the serological diagnosis confirmed the viral etiology in 120 patients (69.7%). HBsAg was present in 33.7% (with HBeAg in 5%), anti-HCV antibodies 22.6% and markers for both viruses in 13.4% of cases. The HCV etiology was more frequently found in chronic hepatitis (44.9%) in liver cirrhosis (50.7%). The smaller number of patients displaying simultaneously anti-HBs and anti HCV antibodies did not confirm the recent suggestions that HCV would be the most important hepatotropic virus which enhances HBsAg clearance in chronic hepatitis.

Adult↗