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Biomedical subjects

M Connor

Publications and source records attributed to M Connor.

59 records · Page 4Linked to original sources
PubMed1980

Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats.

Male weanling rats were given a standard amount (375 micrograms) of aflatoxin B1; some were then exposed to dietary diethylnitrosamine (DEN) in varying concentrations ranging from 5 to 80 ppm for 20 weeks. They were maintained for an additional period of time following DEN exposure and then killed for gross and microscopic examination. DEN at 5 ppm did not enhance aflatoxin B1 liver carcinogenesis. Ten ppm or more of DEN, however, enhanced liver carcinogenesis and introduced two additional target organs; angiosarcomas of the lung and squamous cell carcinomas of the stomach types of tumors which have not been observed after treatment with DEN alone, were noted.

Aflatoxin B1↗
PubMed1979

Clostridial sepsis following hepatic arterial infusion chemotherapy.

Three patients with clostridial sepsis during or following hepatic arterial infusions for the regional chemotherapy of hepatic metastatic tumors are described. In all patients abdominal roentgenograms revealed lucencies in the right upper quadrant consistent with gas-containing hepatic abscesses at the time of clinically apparent sepsis and positive blood cultures. The occurrence of three such cases in one year and the low incidence of clostridial infections in non-catheterized oncology patients at our institution suggest that clostridial infection is a previously unrecognized complication of hepatic arterial infusion chemotherapy. The possible sources of the infecting organisms and pathogenesis of this infection are discussed.

Adult↗
PubMed1975

Tetralogy of Fallot: a morphometric and geometric study.

Fourteen examples of tetralogy of Fallot were studied by morphometric and geometric methods, and the findings compared with results from 10 normal hearts. The data show that in Fallot's tetralogy the conal septum is deviated anteriorly. The infundibulum, although narrow, is similar to, or of greater length than, that of the normal heart. This finding is not in agreement with the recent observations suggesting that the anomaly represents lack of growth of the pulmonary conus. Our results further demonstrate that the aorta is dextroposed in Fallot's tetralogy and that in the majority of cases absorption of the right extremity of the conoventricular flange has led to aortic-tricuspid fibrous continuity. The overall findings indicate that conal rotation has occurred in addition to anterior deviation. The data are interpreted as supporting a hypothesis of "lack of conal inversion" and conal malseptation as the morphogenetic mechanisms in tetralogy of Fallot.

Adolescent↗
PubMed1973

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Nurse-Patient Relations↗