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Biomedical subjects

M Coleman

Publications and source records attributed to M Coleman.

At least 343 records · Page 19Linked to original sources
PubMed1976

A clinical study of the lupus anticoagulant.

Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus anticoagulant was augmented in 67% of these patients by a cofactor present in normal plasma. The lupus inhibitor was detected primarily because of an unsuspected abnormal coagulation test. One-half of the patients with the lupus-type anticoagulant did not have systemic lupus erythematosus.

Anticoagulants↗
PubMed1975

Prolonged interval hyposensitization therapy in hymenoptera-sensitive patients.

The Committe on Insects of the American Academy of Allergy has conducted a 10-year study of 397 patients with Hymenoptera allergy treated with glycerosaline or aqueous whole body mixed Hymenoptera extracts at intervals of 2 or 3 months for the maintenance doses. Patients had few reactions, although in some cases local reactions presented lengthening of the interval. The clinical response was similar to that from conventional therapy using the 4-wk interval for maintenance doses. This type of therapy offers the added advantages of fewer patient visits and decreased cost.

Adolescent↗
PubMed1975

Fibrinogen survival in cirrhosis: improvement by "low dose" heparin.

The effect of "low dose" heparin therapy on fibrinogen survival in patients with cirrhosis was studied in six patients. Survival of I-125 radiolabeled fibrinogen was measured using both autologous and homologous material. Average fibrinogen half-life before heparin therapy was 52 hours and after 3000 units of intravenous heparin every 6 hours was 101.8 hours. Median survival before heparin therapy was 56 hours and after therapy was 91 hours. In every instance fibrinogen survival was improved by heparin administration. These data indicate that "low dose" heparin improves fibrinogen survival in cirrhosis and suggest that disseminated intravascular coagulation is a primary process in the defibrination syndrome associated with cirrhosis.

Disseminated Intravascular Coagulation↗
PubMed1975

The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.

The contents of serotonin (hydroxytryptamine) and pyridoxal phosphate (PLP) in the blood of 11 hyperactive children and 11 controls were determined on an outpatient basis. A significant decrease in serotonin content was found in blood samples from hyperactive patients as compared with controls. There were no differences in PLP content of blood between the two groups. Four children were selected for a study of the effects of pyridoxine hydrochloride (vitamin B6) on low serotonin levels. Oral doses of pyridoxine resulted in an appreciable increase in the serotonin content and a very large increase in the PLP content of blood in these hyperactive patients.

Adolescent↗
PubMed1975

Platelet monoamine oxidase in children with infantile autism.

Platelet monoamine oxidase activity was measured in 9 autistic subjects and 9 controls. There were no significant differences in the rates of metabolism of 5-hydroxytryptamine, dopamine or tyramine between the two groups, although the rate of metabolism of tyramine was more rapid than 5-hydroxytryptamine or dopamine within each group. It is concluded that the data presented do not support the view that measurement of platelet monoamine oxidase can be used as a biochemical index to aid in the clinical diagnosis of infantile autism.

Adolescent↗
PubMed1975

Diagnosis of plasma cell myeloma.

Diagnosis of myeloma depends on identification of malignant plasma cells and the product of these cells, a monoclonal immunoprotein. Of the clinical manifestations of plasma cell myeloma, skeletal pain and anemia are two of the more common. Unexplained anemia and osteoporosis noted in the elderly should suggest the possibility of myeloma; this combination of symptoms certainly warrants obtaining a protein electrophoresis. Hypercalcemia and renal insufficiency are frequent sequelae of myeloma.

Anemia↗