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Biomedical subjects

M Cohen

Publications and source records attributed to M Cohen.

At least 577 records · Page 32Linked to original sources
PubMed1991

Iliac versus cranial bone for secondary grafting of residual alveolar clefts.

Secondary bone grafting of the maxilla in the mixed transitional dentition stage has become a well-accepted procedure in the surgical protocol for rehabilitation of patients with residual alveolar clefts. This retrospective study was undertaken to evaluate and compare the long-term results obtained with iliac or cranial cancellous bone graft material in the area of alveolar clefts and was based on the independent experience of two plastic surgeons from the same center using exclusively cranial or iliac cancellous bone, respectively. The criteria for surgery were similar. The surgical technique, with the exception of the bone-grafting material, also was similar, and all patients were treated by the same group of orthodontists. Fifteen patients from each group, from a total of over 100 patients, were randomly selected and included in the study. All patients were followed up from 18 to 60 months. Operative and perioperative parameters, donor-site morbidity, and long-term results were evaluated, compared, and analyzed. There were no significant differences between the two groups, and equally good results in terms of bone incorporation, tooth eruption, and appearance were obtained with both iliac and cranial bone grafts. We conclude from our study that successful bone grafting is primarily achieved by adherence to meticulous surgical technique, simultaneous closure of coexisting oronasal or palatal fistulae, use of cancellous bone particles only, and coverage of the grafts with well-vascularized flaps. The source of bone graft does not seem to primarily influence the success of the outcome.

Alveolar Process↗
PubMed1991

The effects of labetalol and prazosin on exercise haemodynamics in hypertensive patients.

The antihypertensive and haemodynamic effects of labetalol were compared with those of prazosin both at rest and during bicycle exercise in 38 moderate to moderately severe hypertensive patients (supine DBP 95 to 119 mmHg when untreated). Following a two week open placebo phase to establish baseline BP and baseline exercise performance, patients were randomly and double-blindedly assigned to receive labetalol or prazosin. Drug dose was titrated from 100 to 400 mg labetalol twice daily, or from one to 10 mg prazosin twice daily at weekly intervals until BP was controlled (supine DBP less than or equal to 90 mmHg with at least a 10 mmHg decrease from baseline). Eighteen labetalol and twenty prazosin patients achieved BP control and were subsequently reexercised to fatigue on a bicycle ergometer. The mean changes from baseline for heart rate and rate pressure product (heart rate x SBP) were reduced only in the labetalol group; the difference between the labetalol and prazosin groups was significant (P less than 0.01) both at rest and during exercise. This haemodynamic profile of labetalol may be important in selecting a vasodilating antihypertensive for patients with concomitant ischaemic heart disease.

Adult↗
PubMed1991

Meniscal-bearing unicompartmental knee arthroplasty. An 11-year clinical study.

From 1977 through 1987, 21 meniscal-bearing unicompartmental knee arthroplasties (UKAs) were performed on 20 patients in preference to a distal femoral or proximal tibial osteotomy for unicompartmental knee arthritis. Preoperative diagnoses were osteoarthritis (14 cases), posttraumatic arthritis (5 cases), and rheumatoid arthritis (1 case). Eighteen UKAs (7 lateral, 11 medial) were followed for 24 to 132 months (mean, 34). Using the New Jersey Orthopedic Hospital Knee Scoring Scale, good to excellent clinical results were found in 16 (89%) of the UKAs followed for at least two years. These scores represent significant improvement over preoperative evaluation, (paired t test, P less than or equal to .05). No statistical difference was noted in postoperative results between the lateral or medial arthroplasties (Student's t test, P less than or equal to .05).

Adult↗
PubMed1990

Usefulness of antithrombotic therapy in resting angina pectoris or non-Q-wave myocardial infarction in preventing death and myocardial infarction (a pilot study from the Antithrombotic Therapy in Acute Coronary Syndromes Study Group).

In a prospective pilot trial of antithrombotic therapy in the acute coronary syndromes (ATACS) of resting and unstable angina pectoris or non-Q-wave myocardial infarction, 3 different antithrombotic regimens in the prevention of recurrent ischemic events were compared for efficacy. Ninety-three patients were randomized to receive aspirin (325 mg/day), or full-dose heparin followed by warfarin, or the combination of aspirin (80 mg/day) plus heparin and then warfarin. Trial antithrombotic therapy was added to standardized antianginal medication and continued for 3 months or until an end point was reached. Analysis, by intention-to-treat, of the 3-month end points, revealed the following: recurrent ischemia occurred in 7 patients (22%) after aspirin, in 6 patients (25%) after heparin and warfarin, and in 16 patients (43%) after aspirin combined with heparin and then warfarin; coronary revascularization occurred in 12 patients (38%) after aspirin, in 12 patients (50%) after heparin and warfarin, and in 22 patients (60%) after aspirin combined with heparin and then warfarin; myocardial infarction occurred in 1 patient (3%) after aspirin, in 3 patients (13%) after heparin and warfarin, and in no patient after aspirin combined with heparin and then warfarin; no deaths occurred after aspirin or after aspirin combined with heparin and then warfarin, but 1 patient (4%) died after warfarin alone; major bleeding occurred in 3 patients (9%) after aspirin, in 2 patients (8%) after heparin and warfarin, and in 3 patients (8%) after aspirin combined with heparin and then warfarin. Recurrent myocardial ischemia occurred at 3 +/- 3 days after randomization.(ABSTRACT TRUNCATED AT 250 WORDS)

Angina Pectoris↗
PubMed1990

The anomalous 3.43 and 3.53 micron emission features toward HD 97048 and Elias 1: C-C vibrational modes of polycyclic aromatic hydrocarbons?

We have obtained 5-8 microns spectra toward the two protostellar sources HD 97048 and Elias 1. Besides the well-known family of IR emission bands at 3.3, 6.2 "7.7," 8.7, and 11.3 microns, these objects show strong anomalous emission features at 3.43 and 3.53 microns. No related anomalous bands were found in the new spectra. Combining our results with earlier data, it is shown that, while the anomalous bands are emitted from within 0".05 (approximately 10 AU) of HD 97048, the emission in the general IR features is extended on at least a 20" scale. Some possible assignments of the anomalous emission features are discussed, namely C-H stretching modes in -CHO or -CH2-/-CH3 groups (either in dust grains or as sidegroups on polycyclic aromatic hydrocarbon molecules [PAHs]), and vibrational modes of PAHs without sidegroups. The absence of related anomalous emissions in the 5-8 microns region as well as the high-excitation conditions in the emission zone of the anomalous features make an origin in molecular (side-)groups in grains or on PAHs unlikely. Given the high energy density in the emission zone, as well as the apparent correspondence of the anomalous 3.43 and 3.53 microns features with weak emission shoulders associated with the general family of IR emission bands, it is concluded that an explanation in terms of C-C overtones and combination bands of highly excited, large PAHs or PACs (polycyclic aromatic carbons, i.e., dehydrogenated PAHs; > 500-1000 C atoms) is at the moment most attractive.

Astronomical Phenomena↗
PubMed1990

[Sites of endometriosis].

Endometrious may be located in many parts of the body which are not limited to the pelvic region. While the classical theory of menstrual reflux easily accounts for the genital locations, other theories, notably metaplasia, have been propounded to explain more remote locations. Among the sites of implantation of the disease, the most common is the ovary followed, in order of frequency, by the anterior and posterior parts of the vaginal fornix, the broad ligament of the uterus and the uterosacral ligaments. Endometriosis of the digestive or urinary tract may create problems of differential diagnosis with cancer. External locations are much less frequent.

Adolescent↗
PubMed1990

Worry changes decision making: the effect of negative thoughts on cognitive processing.

The present studies demonstrate that daily worry level is predictive of cognitive processing differences and that these differences are an effect of negative thoughts. In Study 1, worriers (those who reported 50% or greater daily worry) and non-worriers performed a categorization task. The groups did not differ when the stimulus was a clear member or non-member of the category. Worriers showed a significant disruption in processing as the ambiguity of the category membership increased. Study 2 demonstrated that the disruption arose as a result of increased levels of negative thoughts. Worriers and non-worriers were assigned to two conditions, either O-worry ("Relax and let your mind wander for 15 minutes") or 15-worry ("Worry as you typically would for 15 minutes"). Non-worriers evidenced the same disruptive effects in the 15-worry condition as worriers in that condition and worriers in Study 1. Similarly, worriers in the O-worry condition showed a reduction in disruptive effects. The findings are taken as indicating that worry is accompanied by changes in cognitive processing and that these changes are similar for worriers and non-worriers.

Anxiety↗
PubMed1990

Frequency of 47, +21 in cells of blood cultures from couples with habitual spontaneous abortion.

Karyotyped specimens of peripheral blood from 1,055 chromosomally normal individuals (573 females, 482 males) presenting with habitual spontaneous abortion were examined for aneuploidy. Trisomy 21 was noted in six of 14,802 cells. These data were not significantly different from those obtained on chromosomes 19 and 20, or the data obtained from three different, smaller, control groups. The low rate of trisomy 21 cells found in this study suggests that we cannot extrapolate from events in somatic cells in mitosis to nondisjunction events in meiosis.

Abortion, Habitual↗
PubMed1990

Placebo-controlled trial of once-a-day isradipine monotherapy in mild to moderately severe hypertension.

The efficacy and safety of once-daily dosing of isradipine, a new calcium antagonist vasodilator, was evaluated in a multicenter, placebo-controlled trial in hypertensive patients who had supine diastolic blood pressure (SDBP) 100-119 mm Hg. After a 3-week single-blind placebo washout patients randomly received either isradipine, 5 mg once daily, or a matching placebo; if SDBP remained greater than or equal to 95 mm Hg or less than or equal to 10 mm Hg below baseline at four weekly clinic visits, isradipine was increased at weekly intervals by 5 mg once daily up to 20 mg and maintained during weeks 5 and 6. At week 6 mean supine blood pressure 24 hours after dosing had declined from 163 +/- 20/105 +/- 5 (N = 78) to 146 +/- 17/92 +/- 7 mm Hg (N = 60) on isradipine, 14.5 mg once daily, and from 163 +/- 20/105 +/- 6 (N = 85) to 157 +/- 18/99 +/- 10 mm Hg (N = 64) on placebo (P less than .001 between groups). Standing blood pressure decreased from 159 +/- 20/104 +/- 8 to 144 +/- 18/93 +/- 11 mm Hg with isradipine and from 160 +/- 22/105 +/- 9 to 154 +/- 19/101 +/- 11 mm Hg with placebo (P less than .001 between groups) without signs or symptoms of postural hypotension. A SDBP less than or equal to 90 mm Hg or a greater than or equal to 10 mm Hg fall below baseline was achieved in 41 of 78 isradipine-treated (53%) and 18 of 85 placebo-treated subjects (21%).(ABSTRACT TRUNCATED AT 250 WORDS)

Antihypertensive Agents↗
PubMed1990

Epidural analgesia for a parturient with herpes gestationis.

A 23-yr-old parturient with herpes gestationis spontaneously delivered a normal healthy infant under epidural analgesia. She received five injections of bupivacaine 0.5 per cent over a ten-hour period. There was no infection at the lumbar region, even though her body was covered with vesicles and bullae including the face and neck. Eight months after delivery the patient still has a vesicular eruption which occurs mainly during her menses.

Adult↗
PubMed1990

Neurodevelopmental differences in emotional prosody in normal children and children with left and right temporal lobe epilepsy.

Emotional prosody, which has been defined as the emotional aspects of speech which communicate pleasure, fear, sorrow, anger, etc., has been demonstrated to be primarily a function of the nondominant hemisphere (typically, the right hemisphere) in adult populations. However, few researchers have addressed the developmental or lateralized nature of emotional prosody in children. In this study, an instrument was developed to measure the receptive aspects of emotional prosody in pediatric populations and administered to normal children ages 6 to 11 years old. An analysis of variance revealed significant age-related differences. Additionally, the instrument was administered to 12 children with right temporal lobe epilepsy and 11 children with left temporal lobe epilepsy. Analysis of variance indicated that there was no significant difference in scores between the left temporal and right temporal lobe groups. However, right temporal epileptic patients scored significantly lower than normal children on all sections of the instrument, suggesting that in children like adults, the right temporal lobe may be dominant with respect to the receptive aspects of emotional prosody.

Brain Damage, Chronic↗
PubMed1990

Fluosol and oxygen breathing as an adjuvant to radiation therapy in the treatment of locally advanced non-small cell carcinoma of the lung: results of a phase I/II study.

Fluosol, a perfluorcarbon emulsion, has the ability to carry oxygen in solution. In conjunction with oxygen breathing and radiation, Fluosol has been shown in animal models to enhance local tumor control. In September 1985, a Phase I/II Study was instituted to evaluate the effect of this adjuvant therapy with radiation in non small cell carcinoma of the luing. Fifty patients were enrolled in the study which was closed for accrual in November 1987. Five patients were withdrawn prior to the institution of radiation: one patient diagnosed with bone metastasis and four patients withdrawn due to mild to moderate reactions to Fluosol. Of the 49 patients administered Fluosol, 34 mild to moderate adverse reactions were noted in 22 patients to either the test dose/infusion (16 reactions including withdrawn patients) or post infusion (18). Flushing, dyspnea and hypertension (test dose/infusion) and chills and/or fever (postinfusion) were the typical symptoms. Transient elevation of blood chemistries (SGOT, SGPT, alkaline phosphatase, BUN) were noted in some patients. Six patients had transient depression of WBC counts (toxicity scores of 1 or 2) and two patients had transient depression of platelets (toxicity score of 1). None of these altered treatment. Forty-five patients received Fluosol of which 34 completed the planned therapy. Six patients were diangosed with metastatic disease during therapy and three patients died of their disease during treatment. One patient was withdrawn due to ineligibility and one patient withdrawn due to moderate reactions to Fluosol during the 3rd and 4th infusions. The total dose of Fluosol was escalated from 42 mL/Kg to 49 mL/Kg in 5, 6, or 7 weekly infusions. Patients breathed 100% oxygen for a minimum of one-half hr prior to and during radiation treatment. Radiation therapy was administered at a daily fraction of 165 to 200 cGy per fraction to a total dose of 5940 to 6800 cGy. Seventeen of 34 patients (50%) achieved a complete response to treatment and 11 patients (32%) had a partial response. Thirteen patients remain alive (range of 12 to 20 months) including 10 of 17 complete responders, 2 of 11 partial responders, and 1 treated with chemotherapy postradiation. The median absolute survival time of the patients completing therapy was 15.5 months and the 12 and 18 month absolute survival rates were 81% and 74%, respectively. The 45 patients starting protocol therapy had a median absolute survival of 9.2 months with a 12-month and 18-month survival of 45% and 35%, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

Aged↗
PubMed1990

Ascorbic acid safety: analysis of factors affecting iron absorption.

The potential for excessive iron absorption by subjects ingesting ascorbic acid doses above the recommended dietary allowance (60 mg) was evaluated by examining published literature (24 studies, 1412 subjects) in which ascorbic acid was part of a test meal given to determine effects on iron absorption. Three parameters associated with iron absorption were identified: (1) a relatively shallow slope for the dose-response curve relating ascorbic acid dosage (1-1000 mg) and percent iron absorption; (2) no significant effect of ascorbic acid on the absorption of high (60 mg) iron doses; and (3) an inverse relationship between iron absorption and plasma transferrin saturation. Ascorbic acid did not increase the incidence of 'high' iron absorbers (greater than 2 SD from population mean) above control levels; limited data for ascorbic acid doses greater than 100 mg/d indicated no change in the distribution of iron absorption values.

Adult↗
PubMed1990

Angiographic patterns of balloon inflation during percutaneous transluminal coronary angioplasty: role of pressure-diameter curves in studying distensibility and elasticity of the stenotic lesion and the mechanism of dilation.

There are few in vivo data concerning the mechanisms of balloon inflation during coronary angioplasty. To characterize how lesions dilate, videodensitometry was used to measure the diameter of the inflated balloon across 29 coronary lesions in 27 patients. Pressure-diameter curves for each lesion were derived with use of a standardized incremental inflation protocol in which pressures between 2 and 6 atm in 3 mm low profile balloons approximated normal vessel diameter. The diameter of coronary stenosis before and after angioplasty was also measured. Pressure-diameter curves showed that the most improvement in luminal caliber occurred at low inflation pressure. A distensibility factor was defined as the ratio of the amount of balloon inflation at 2 atm compared with the balloon diameter at 6 atm. Eccentric irregular lesions (n = 11) had a greater distensibility factor (0.49 +/- 0.17) than did lesions (n = 18) without this configuration (0.33 +/- 0.14) (p less than 0.02). The former were soft, presumably because of thrombus in these lesions. In addition, there were no differences in patterns of balloon inflation for lesions requiring additional inflation or for dilations resulting in an intimal crack or dissection after angioplasty. There was often a loss of luminal caliber when balloon diameter at 6 atm was compared with the diameter after angioplasty. This was defined as elasticity or recoil. There was a significant direct correlation between the amount of elasticity and the extent of balloon inflation at 6 atm (that is, lesions more fully dilated at 6 atm showed more elasticity).(ABSTRACT TRUNCATED AT 250 WORDS)

Angiography↗