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Biomedical subjects

M Cleveland

Publications and source records attributed to M Cleveland.

6 recordsLinked to original sources
PubMed1994

Decreased levels of soluble amyloid beta-protein precursor are associated with Alzheimer's disease in concordant and discordant monozygous twin pairs.

We conducted immunochemical measurements of soluble amyloid beta-protein precursor (beta PP) in cerebrospinal fluid (CSF) from three monozygous twin pairs. Two of the twin pairs are discordant for Alzheimer's disease and one pair showed concordance for Alzheimer's disease, which was confirmed neuropathologically. All affected individuals displayed substantially lower levels of soluble beta PP in CSF compared with the unaffected individuals. There were no differences in total protein levels in CSF samples from the affected twins compared with those of the unaffected twins. These studies suggest that decreased soluble beta PP in CSF may reflect neuropathological processes in Alzheimer's disease involving beta PP.

Aged↗
PubMed1981

Families and adolescent drug abuse: structural analysis of children's roles.

This paper presents an analysis of sibling roles in families that have problems related to adolescent chemical abuse. It is based on material gathered during an exploratory research project directed toward structural evaluation of these families. The analysis identifies even sibling roles. The roles of Parental Child, Good Child, and Symptomatic Child are characterized as those with major structural impact. Four auxiliary roles of child Advocate, Analyst, Peacemaker, and Therapist are also described. Structural implications of sibling roles are discussed and suggestions for clinical intervention are presented.

Adolescent↗
PubMed1979

Family adaptation to the traumatic spinal cord injury of a son or daughter.

The article presents the case history of a family in which an adolescent son receives a traumatic spinal cord injury. The focus of the study is on the adaptation of the family unit to the permanent disablement of their dependent child. The family's grief reaction is examined as are their patterns of adaptation in family task organization, affection, communication, and power structures. The authors also discusses the effect of the injury on specific intrafamily relationships and presents suggestions for clinical intervention.

Adaptation, Psychological↗