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Biomedical subjects

M Cholewa

Publications and source records attributed to M Cholewa.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Effect of moderate hyperglycaemia on left-ventricular systolic time intervals during submaximal exercise of steady workload in healthy subjects.

The effect of submaximal exercise at steady workload on left-ventricular systolic time intervals (STI) was studied in healthy subjects. In group I (22 subjects) 20% glucose solution was injected intravenously in a dose of 2.5 ml/kg of body weight before the exercise. In group II (20 subjects) the same exercise was preceded by intravenous injection of normal saline 2.5 ml/kg of body weight. The left ventricular systolic time intervals were determined by the polycardiographic metod of Blumberger modified by Holldack and Weissler. It was found that glucose administration before the exercise improved myocardial contractility during the exercise. During hyperglycaemia the secondary impairment of myocardial contractility was less pronounced than in the control group. Postexercise changes in left ventricular systolic function regressed more rapidly in the group receiving glucose than in controls.

Adult↗
PubMedDate not supplied

The effect of glucagon on myoinositol levels in the blood serum and its excretion with urine.

The investigations were carried out with a group of ten healthy men aged 20--26 years who were injected intravenously with glucagon in a single dose of 50 microgram per kg of body weight. Glucagon had no effect on myoinositol levels in the blood serum. It caused however, a significant decrease in the myoinositol discharge into urine and lowered the index of renal myoinositol clearance. The creatinine clearance index remained unchanged.

Adult↗
PubMedDate not supplied

[Effect of treatment with vasodilators on physical exercise tolerance in patients with chronic congestive heart failure].

The studies were performed in 46 patients with chronic congestive heart failure (CCHF), III and IV NYHA classes. During the first two weeks all patients received digoxin (D) and furosemide (F) in optimal doses (stage O). Then, patients were randomly divided into two groups. During the stage A group I (n = 26) received digoxin, furosemide and nifedipine (N), while in the stage B captopril (K) was added to that treatment and it was continued for 4 weeks. During the following two weeks (stage C) patients were treated the same as in stage A. During the same stages group II (n = 20) received D, F and isosorbide dinitrate (S), then, D, F, S and K followed by D, F and S, respectively. After the termination of each stage of the treatment all patients performed physical exercise on bicycle ergometer, until limiting symptoms have occurred. Power (M) and duration (t) of exercise, systolic (ps) and diastolic (Pd) arterial blood pressures, heart rate (HR) at the peak load, and HR x Ps and HR/M indices were determined. It was found that N did not significantly affect the investigated ergometric parameters. Combined treatment with D, F, N and K induced an increase in M, t and HR, and a decrease in. This effect persisted through the stage C. Following the treatment with D, F and S, a significant increase in M and decrease in HR/M were observed. Addition of K to D, F, and S did not induce further improvement in the physical exercise tolerance of these patients.

Adult↗
PubMedDate not supplied

[Guillain-Barre syndrome with an especially severe course].

A case of polyradiculoneuritis in a 51-year-old man is reported. Symptoms occurred suddenly. Our serologic tests failed to explain the cause of the illness. Physical examination showed tetraplegia and respiratory muscles paralysis which required continuous use of respirator during six weeks. In the treatment were used: steroid hormones, antibiotics, anabolics, plasmapheresis. In physical treatment: kinesitherapy, massage, electrotherapy, hydrotherapy. After three years of intensive physical treatment patient was cured.

Humans↗