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Biomedical subjects

M Cholewa

Publications and source records attributed to M Cholewa.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Effect of tobacco smoking on plasma sodium, potassium and chloride concentrations and some parameters of acid-base equilibrium during physical exertion and in the course of restitution].

In 30 healthy men, aged 20-24 years, the effect of physical exercise on the concentration of Na and K in serum erythrocyte and whole blood, on the serum chloride concentration and on capillary blood acid-base equilibrium was studied (Group A). In another group of 20 men the same studies were performed after smoking of 4 cigarettes (Group B). Taking into consideration blood condensation plasma Na, K and Cl concentrations were found to be decreased significantly (p less than 0.05). Sodium concentration in erythrocytes increased significantly after exericse in group B as compared with group A (p less than 0.01). Similarly, potassium concentration in erythrocyte increased significantly 30 minutes after exercise in group B as compared with group A (p less than 0.005). There were no differences in changes in acid-base equilibrium after exercise between both groups--they indicated the shift towards metabolic acidosis.

Acid-Base Equilibrium↗
PubMed1977

Effect of physical exercise on gastric basal secretion in healthy men.

Behaviour of basal gastric secretion of electrolytes, lactic acid and pyruvic acid was studied in twenty-minute portions in 14 healthy men in rest, during exercise and restitution. On bicycle ergometer in sitting position all studied men performed the average work 15 120 +/- 1800 kpm during 20 minutes. It was found that basic gastric secretion didn't change significantly during exercise, but its significant decrease occurred during twenty-minute restitution after exercise. During restitution secretion of Cl, Mg and Ca also significantly decreased while their concentrations didn't change in gastric juice. During physical exercise it was found the increase of lactic acid secretion in gastric juice; it was statistically significantly higher during restitution than in rest period (p less than 0.001) and during exercise (p less than 0.02).

Adult↗
PubMed1971

[Aspergillosis].

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Anti-Bacterial Agents↗
PubMedDate not supplied

[Permanent heart pacing in treatment of cardioinhibitory vasovagal syncope (case report)].

Vasovagal syncope is a complex syndrome in which specific methods of treatment rarely are related to clinical success. Since it turned out that some patients with neurocardiogenic syncope were resistant to offered pharmacotherapy, cardiac pacing has been used as the alternative way of long-term therapy. Successive studies, which have estimated clinical efficacy of permanent cardiac pacing, indicate that such method of treatment may reduce symptoms revealed by vasovagal reflex. Nevertheless the optimal pacing mode has not been established yet. It is known that single chamber VVI pacing is not a good and effective method whereas dual chamber DDI pacing with rate hysteresis seems to be very promising in treatment of people suffering from malignant cardioinhibitory vasovagal syncope. DDD pacing with rate drop response, search and scan functions recently has been available to these patients. The results of the North American Vasovagal Pacemaker Study, as well as some casuistic observations referring to patients with vasovagal syndrome, show very high clinical efficacy of dual chamber pacing with mentioned new functions. We present a case of patient with cardioinhibitory vasovagal syncope who was successfully treated by permanent DDD pacing with search and scan hysteresis.

Adult↗
PubMedDate not supplied

[Effect of using nifedipine by patients with chronic congestive heart failure treated with digoxin and furosemide].

Nifedipine was administrated to 25 patients with chronic congestive heart failure treated with digoxin and furosemide++, nifedipine (NF) in a daily dose of 30-80 mg for 14 days. Before and after the treatment with nifedipine chest X-ray, blood biochemical investigations, echocardiographic evaluation of the left ventricular function and submaximal exercise test were performed. Nifedipine induced significant decreases in the left ventricular systolic dimension, heart volume, blood serum potassium and uric acid concentrations and hematocrit . Resting and exertional heart rate, blood pressure, exercise power and duration, watt-pulse, myocardial oxygen demand index, ejection fraction, cardiac output, body weight, 24-hour urinary output, blood serum concentrations of urea, creatinine, sodium and chloride changed insignificantly following nifedipine administration. The obtained results suggest that long-term nifedipine treatment of patients who were already given digoxin and furosemide neither improve nor worsen their clinical status.

Adult↗
PubMedDate not supplied

[Evaluation of nifedipine and captopril as adjuvant drugs in the standard treatment of chronic heart failure].

A group of 25 patients in III-IV haemodynamic period of chronic stagnant circulatory failure (pzns) in clinical conditions for two weeks were administered digoxin and furosemide (DF), then for the following two weeks DF therapy was combined with nifedipine (N), in the following 4 weeks the DFN therapy was combined with captopril (DFNK), in the last two weeks DFN therapy was applied again. The authors used the following doses per 24 h: D--0.29 +/- 0.96 mg, F--13.5 +/- 4.8 mg, N--40.8 +/- 12.8 mg and K 75.0 +/- 28.8 mg. Each cycle of the therapy was followed by a precise clinical evaluation, analysis of the function of the left ventricle by means of two-dimensional echocardiography, the evaluation of the tolerance of physical effort and the evaluation of chest radiograms. Besides, blood was studied for the concentrations of potassium, sodium, chloride, urea, creatinine, uric acid, haematocrit value and pH value. The addition of nifedipine to the classical therapy did not give significant improvement in the clinical condition, haemodynamic parameters and the tolerance of physical effort in patients with pzns. In comparison to DF period, the use of captopryl brought about a statistically significant increase (p less than 0.05) in ejection fraction (EF) from 43.0 +/- 15.3% up to 45.2 +/- 11.7%, in effort power from 36.5 +/- 16.4W up to 47.1 +/- 17.5W, in effort duration from 3.5 +/- 1.6 min. up to 4.5 +/- 1.8 min. and a significant decrease (p less than 0.05) in body weight from 68.1 +/- 13.8 down to 66.9 +/- 13.0 kg and heart volume from 1175.5 +/- 487.3 cm3 down do 1074.6 +/- 380.9 cm3. One could notice, though statistically not significantly (p greater than 0.05) an increase in stroke volume index and cardiae index. Besides, the authors noticed a tendency to an increase in potassium concentration in blood serum. Eliminating captopryl caused fast regression of positive haemodynamic effects, decrease in physical effort tolerance, and clinical condition resumed the condition observed in the period of DFN therapy.

Adult↗