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Biomedical subjects

M Chimienti

Publications and source records attributed to M Chimienti.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Sustained effect of nitroglycerin ointment on exercise tolerance in patients with effort angina (author's transl)].

The effect on exercise tolerance of nitroglycerin (NTG) ointment was studied by exercise test on bicycle ergometer in a selected group of patients with effort angina and angiographically proven critical coronary lesions. NTG ointment (15 mg) and placebo were administered in a double-blind cross-over randomized trial on two consecutive days; exercise test was carried out before the administration of NTG ointment and placebo, and repeated after one hour, 2 and 1/2 hours and 4 hours. Compared to control and placebo tests, NTG ointment produced a highly significant increase of duration of exercise and of total work load in all tests, as well as a significant decrease of maximal ST segment depression. After NTG ointment administration resting systolic blood pressure showed a significant decrease after one hour, 2 and 1/2 hours and 4 hours, resting heart rate a significant increase after 2 and 1/2 and 4 hours, and peak exercise heart rate a significant increase after 4 hours. Double product at rest was unaffected by NTG ointment, while at peak exercise it showed a significant increase only after 4 hours. Our data show that in patients with effort angina NTG ointment produces an important increase of exercise capacity which persists at least for 4 hours after the administration. Therefore NTG ointment seems to be of high value in the treatment of effort angina.

Adult↗
PubMed1980

[Junctional and atrioventricular paroxysmal reciprocating tachycardias: clinical and electrocardiographic characteristics (author's transl)].

Some clinical and electrocardiographic characteristics are reviewed in two groups of patients with paroxysmal junctional reciprocating tachycardia (JRT) (21 cases) and atrioventricular reciprocating tachycardia involving an atrioventricular bypass tract with unidirectional anterograde block (AVRT) (26 cases). Mechanisms of tachycardia were established in all cases by intracavitary electrophysiologic study. Mean age (+/- S.D.) was 46 +/- 18 yrs (range: 14-75) in the JRT group and 32 +/- 16 yrs (6-67) in the AVRT group (p < 0.02). Male/female ratio was 11/10 in the former and 15/11 in the latter. Mean tachycardia rate of the JRT was 178 +/- 24 b/min (130-215) vs. 205 +/- 21 b/min (160-240) of the AVRT (p < 0.001). Only in 4 cases of JRT a second degree A-V block was observed during tachycardia. P wave was recorded just after the end of QRS complex in all cases of AVRT; on the contrary it was completely hidden in the QRS complex in 11 cases (52%), partially superimposed on the end of QRS in 6 cases (29%) and on the beginning of QRS in 4 cases (19%) of the JRT group. A functional bundle branch block during tachycardia was observed only in 3 cases of JRT (14%) vs. 15 cases (58%) of AVRT. The block never induced any change in the tachycardia rate either in the JRT group or in those cases of AVRT with the anomalous pathway heterolateral to the bundle branch block. On the contrary, the block ipsilateral to the anomalous bypass tract constantly induced variations in cycle length during tachycardia. In conclusion, analysis of some clinical and electrocardiographic features may give useful information for the differential diagnosis of JRT and AVRT and so be helpful for a better therapeutic approach.

Adult↗
PubMed1979

Paroxysmal atrioventricular tachycardia involving an anomalous pathway with antegrade unidirectional block.

37 consecutive patients with frequent episodes of palpitation and/or dizziness underwent electrophysiological study. They had no signs of ventricular preexcitation during either sinus rhythm or atrial pacing. In 17 (46%), the supraventricular tachycardia was sustained by a reentry mechanism involving an anomalous AV pathway with unidirectional antegrade block (AV tachycardia). Some findings were accepted to demonstrate the existence of the anomalous pathway (AP) and others, its participation in the reentry circuit. The possible location of the AP was established in 15 cases at the following sites: left lateral in 5 cases, left posterior in 5 cases, left posteromedial in 1 case, right posterior in 1 case, right anterior in 1 case, posterior septal in 1 case, and anterior septal in 1 case. The rate of the AV tachycardia can be influenced not only by the ventriculoatrial interval but also by the other pathways included in the reentry circuit. It may change conspicuously in cases with dual AV pathway and anomalous AV pathway in relation to the modality of antegrade conduction by the AV node.

Adolescent↗
PubMed1978

[Electrophysiological aspects of ectopic atrial tachycardia (author's transl)].

In 10 patients with supraventricular tachycardia who underwent an electrophysiological study the ectopic atrial origin of the tachycardia could be demonstrated by the intracavitary localization of the earliest depolarized point (six cases in the right atrium and four cases in the left). Vagal stimulation and/or the i.v. infection of ATP induced or increased the degree of AV block during tachycardia; in five cases ATP interrupted the tachycardia. On the basis of their clinical and electrophysiological behavior, the patients were divided into two groups. In the first one (6 patients) tachycardia was persistent, started following late atrial beats with the same morphology of the subsequent and showed a progressive initial rate increase (warm-up phenomenon); programmed atrial stimulation failed to start and interrupt it. In the second group (4 patients) tachycardia was paroxysmal or repetitive, started following early atrial beats and could be induced and interrupted by programmed atrial stimulation. With respect to the electrophysiological characteristics of each group the authors try to define the possible mechanism responsible for the tachycardia (automaticity and micro-reentry).

Adenosine Triphosphate↗