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Biomedical subjects

M Chigira

Publications and source records attributed to M Chigira.

67 records · Page 4Linked to original sources
PubMed1987

[The effect of biomaterials on cytochrome c].

The adsorption of ferricytochrome c and ferrocytochrome c on biomaterials was studied by measuring the spectrum of samples assuming the molar extinction coefficients of the ferricytochrome c and ferrocytochrome c at 480 nm and 550 nm. Silica, alumina ceramic, zirconium ceramic, tricalcium phosphate ceramic, hydroxyapatite ceramic, unidirectional calcium phosphate glass-ceramic, bulk crystallized calcium phosphate glass-ceramic and bulk crystallized calcium phosphate glass-ceramic containing large amount of titanium were used as adsorbents. The adsorption of ferricytochrome c or ferrocytochrome c on silica essentially followed the Langumuir adsorption isotherm. Quantitative analysis showed that ferricytochrome c was adsorbed more and dissolved less than ferrocytochrome c on batch adsorption on silica. Total amounts of adsorbed and non-adsorbed ferricytochrome c increased significantly in batch adsorption of ferrocytochrome c on silica. From these experiments it appears that materials such as silica induce a transfer of electrons of cytochrome c.

Adsorption↗
PubMed1986

Radiological evidence of healing of a simple bone cyst after hole drilling.

We report the long-term results with ten patients with simple bone cysts with special retrospective reference to the radiographic evidence of healing after hole drilling. Cortical thickening was initially observed within 3 months, and minimal new bone formation around Kirschner wires left in situ was observed within 4 months. New bone formation gradually progressed from the cyst wall and around the wire. Consolidation of a cyst cavity was uniformly observed 6-7 months after drilling. In several patients residual cysts were seen between the wire and cortical shell. In younger patients, a cystic cavity reappeared after extraction of the wire, although complete radiographic healing had been observed. These findings suggest that a Kirschner wire plays an important role in preventing relapse of simple bone cysts after hole drilling.

Adolescent↗
PubMed1986

Internal pressure and oxygen tension of bone tumors and tumorous conditions.

Internal pressure and oxygen tension were measured in 24 patients with bone tumors and tumorous conditions. High internal pressures were observed in most of the rapidly growing lesions. The internal pressures of slowly growing and non-growing lesions were not different from those of normal bone marrow. Oxygen tension was commonly higher in the rapidly growing lesions than in simultaneously obtained peripheral venous samples from the same patients. The oxygen tension of the fluid from simple bone cysts was lower than that in venous samples from the same patients. There is a good correlation between internal pressure and the growth rate of the bone lesions in this study. It is suggested that internal pressure and oxygen tension of the lesions demonstrated the degree of blood supply to the bone tumors and tumorous conditions.

Adolescent↗
PubMed1986

[Sternocostoclavicular hyperostosis: a report of nineteen cases with special reference to its etiology and treatment].

Nineteen patients with sternocostoclavicular hyperostosis were reviewed retrospectively. Of particular interest were their responses to antibiotics and prostaglandin inhibitors. The prostaglandin inhibitors relieved the pain within four weeks in 16 of 18 patients. In most cases, however, the inhibitors gradually became less effective. Oral antibiotics were more effective than the inhibitors in relieving the pain in 8 of 10 patients who were given antibiotics. Pustulosis palmaris et plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy as did the chest pain in most cases. The similarities between age and sex distribution, and the responses to antibiotics of the patients with sternocostoclavicular hyperostosis and those with pustulosis suggest that these disorders have a common etiology, and that the pustulosis may represent "bacterid reaction", and the hyperostosis may also be a manifestation of a systemic reaction to a focal infection.

Adult↗
PubMed1986

Sternocostoclavicular hyperostosis. A report of nineteen cases, with special reference to etiology and treatment.

The cases of nineteen patients with sternocostoclavicular hyperostosis were reviewed retrospectively. Of particular interest were the responses to antibiotics and prostaglandin inhibitors. The prostaglandin inhibitors relieved the pain within three to four weeks in sixteen of eighteen patients so treated. However, the inhibitors gradually became less effective in most patients. Oral antibiotics were more effective than the inhibitors in relieving the pain of eight of the eleven patients who were given antibiotics. Pustulosis palmaris and plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy, as did the chest pain in most patients. The similarities between the age and sex distributions and the responses to antibiotics of the patients with sternocostoclavicular hyperostosis and those with pustulosis suggest that these disorders have a common etiology, and that the pustulosis may be a so-called bacterid reaction and the hyperostosis, a manifestation of a systemic reaction to a focal infection.

Adult↗
PubMed1985

[Studies on the internal pressure of bone tumors and tumorous conditions. I. Pain and internal hypertension of bone lesions].

Internal pressure of bone tumors and tumorous conditions were measured in twenty patients. High pressure were frequently found in the patients with painful bone lesions while low pressures were common in the patients with no pain. High internal pressure may be a causative factor of aching bone pain at rest. It is suggested that venous obstruction without high internal pressure is not a causative factor of bone pain in simple bone cyst.

Adolescent↗
PubMed1984

Pain and internal hypertension in bone lesions.

Internal pressures of bone tumors and tumorous conditions were measured in 20 patients. High pressures were frequently found in patients with painful bone lesions while low pressures were common in patients with no pain. Internal hypertension may be a causative factor of aching bone pain at rest.

Blood Pressure↗
PubMed1983

The aetiology and treatment of simple bone cysts.

The internal pressure of simple bone cysts was found to be slightly higher than the normal pressure of the bone marrow in the contralateral limb. The pressure within the cyst was measured during drilling with a Kirschner wire; it gradually decreased as the number of drill-holes increased. The PO2 of the cyst fluid was markedly lower than that of either venous or arterial blood measured synchronously. It is suggested that venous obstruction in the bone is the likely cause of these cysts. Seven patients with simple bone cysts were treated by the multiple drill-hole method, and the clinical outcome was excellent. Multiple drilling may prove to be the treatment of choice for simple bone cysts in the younger patient, as it presents fewer hazards than other procedures.

Adolescent↗
PubMed1983

[Enhancement of tumor-specific killer T cell activities by high-dose methotrexate].

High-dose methotrexate (100 mg/kg) and citrovorum factor rescue enhanced syngeneic sarcoma (S1509a) specific killer T cell (cytotoxic T lymphocyte) in tumor bearing mice, although high-dose MTX suppressed killer T cell against S1509a in immunized mice. It was suggested that tumor specific suppressor T lymphocyte played an important role in enhancement of killer T cell. Enhancement of killer T cell was induced at day seven after administration of MTX. From the clinical point of view, weekly high-dose (100 mg/kg) MTX therapy may be necessary to enhance tumor specific immunity of the patients with sarcoma. High-dose MTX therapy is a unique one not only in practical point of view, but also in immunological point of view.

Animals↗
PubMed1983

[Simple bone cyst--pathophysiology and treatment].

Internal pressure of simple bone cyst was slightly higher than normal bone marrow pressure measured on contralateral side. Internal pressure of the cyst measured during drill-holing with Kirschner wire gradually decreased along with the increase in the number of drill-holes. Internal PO2 was markedly lower than PO2 of venous and arterial blood measured synchronously. Venous obstruction in bone may be an etiology of simple bone cyst. Follow up study showed that all cysts of six cases treated by the multiple drill-hole method were filled up with bony tissue within five months after the treatment, and the clinical result of the treatment was excellent. Multiple drill-hole method may be the first choice in the treatment of simple bone cyst in the younger patients, because the operative invasion of this method was minimum.

Adolescent↗
PubMed1983

[Basic characteristics of Gunma clone-4 in the experimental study of metastasis].

Gunma clone-4 (Gc-4) cell was isolated by limiting dilution method from Radiological Science-Chiba- Toyama sarcoma which appeared spontaneously in a C3H/He mouse and cultured for generations. The character of Gc-4 cells was as follows: Gc-4 cells grew exponentially in vivo and in vitro, and the doubling time was 3.4 to 4.2 days in vivo and 20 to 22 hours in vitro respectively. Inoculation of 1 X 10(6) Gc-4 cells into A/Jackson mice and C57BL/6 mice resulted in rejection and disappearance within 17 days. Inoculation of 1 X 10(6) Gc-4 cells into C3H/He mice which were immunized with Gc-4 cells treated with 100 micrograms/ml of mitomycin C for 30 min. did not result in rejection. The Gc-4 cells showed histiocytic and fibroblastic characteristics morphologically and functionally, and corresponded to human malignant fibrous histiocytoma. Experiments on artificial and natural metastasis of Gc-4 cells revealed that Gc-4 cells had a high colony forming efficiency.

Animals↗