Biomedical subjects

M Cherry

Publications and source records attributed to M Cherry.

77 records · Page 5Linked to original sources

PubMedDate not supplied

Effect of rabbit strain on activity level and cytotoxicity of serum complement. III. Comparison of four tumor target cells.

Serum samples from about 10 males and 10 females from each of 15 genetically defined strains of rabbits and from one hybrid were tested as sources of complement for the microtiter lymphocytotoxicity test using tumor cells from SaI-A, 6C3HED-A, BW5147, and L-cells as target cells. The tumor cells were tested with appropriate H-2 antisera. Results indicated strain differences particularly evident when the target cells were eithter 6C3HED-A or L-cells. BW5147 worked well with most all strains and SaI-A was extremely demanding of all strains of rabbits. However, strains IIIC/J, IIIVO/J and the F1 hybrid between them were still among the six best strains when tested against the tumor cells as they were when tested against the lymph nodes in previously published data. Strain WH/J which carries the gene, ha, for hereditary lymphosarcoma, proved to be a good complement source with SaI-A and 6C3HED-A, both sarcoma in nature. However, it was not a good complement source with BW5147, a lymphatic leukemia, or L-cells. This is possible evidence for a common tumor antigen associated with lymphosarcoma.

Animals↗

PubMedDate not supplied

Pathways for continence care: development of the pathways.

This article is the second in a series of three covering a project into the use of care pathways for continence care undertaken by the authors. Loddon NHS Trust, Wiltshire and Swindon Healthcare NHS Trust and Salisbury Healthcare NHS Trust collaborated and supported their continence advisers in moving from financially driven assessment data to writing evidence-based care pathways and supporting patient information. The first article (Vol 9(9): 590-6) described the issues facing the continence advisers and the background to their decision to use full evidence-based care pathways. It also gave the results of an audit demonstrating that high quality equitable continence care was not reaching each patient. This article covers the literature search and the problems encountered in the setting up of a database and the development of a generic pathway, a symptom profile and specific pathways. It describes how each pathway evolved and was underpinned with the relevant evidence. It further describes the supporting information and design problems. Finally, it gives information on piloting the care pathways.

Critical Pathways↗

PubMedDate not supplied

Pathways for continence care: background and audit.

This article is the first in a series of three covering the use of care pathways for continence care. Trusts in Basingstoke, Swindon and Salisbury have collaborated in supporting their continence advisers in moving from finance-driven assessment data to evidence-based care pathways and the provision of patient information. This article identifies the background and approach to care pathways and addresses the quality issues. It details the issues facing continence advisers and how care pathways may help to address them. Furthermore, it describes a baseline audit which was carried out to ensure that facts rather than beliefs were being used and this demonstrated that little advice or treatment was actually reaching the patient.

Aged↗

PubMedDate not supplied

Pathways for continence care: the validation process.

This article is the third in a series of three describing a collaborative project between continence advisers in Loddon NHS Trust, Basingstoke, East Wiltshire Healthcare Trust, Swindon, and Salisbury Healthcare Trust to develop and implement care pathways to improve continence care provided to patients. The first article described the issues facing the continence advisers and the background to the decision to develop evidence-based care pathways (Vol 9(9): 590-6). The second covered the literature search and described how each pathway evolved (Vol (17): 1165-72). This article outlines the mechanisms by which the care pathways were subjected to a process of content validation.

Attitude of Health Personnel↗

PubMedDate not supplied

Mapping of the X-breakpoint involved in a balanced X;12 translocation in a female with mild mental retardation.

Balanced chromosomal abnormalities such as translocations and inversions have been identified in many genetic diseases. Cloning of the breakpoints involved in these abnormalities has led to the identification of the disease-related genes. Recent reports suggest the presence of a mental retardation locus at Xq11-12. We have identified a female patient with a balanced translocation t (X;12) (q11;q15) associated with mild mental retardation. We identified a yeast artificial chromosome spanning the X-chromosome breakpoint by using fluorescent in situ hybridization techniques. A cosmid library of this YAC has been constructed and the search for candidate genes is in progress.

Child↗