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M Chadha

Publications and source records attributed to M Chadha.

At least 37 records · Page 2Linked to original sources
PubMed1996

Radiation therapy of metastatic pheochromocytoma: case report and review of the literature.

Malignant pheochromocytomas are rare tumors, which are considered radioresistant on the basis of little information. We report a patient, with cranial nerve deficits from a pheochromocytoma metastatic to the parasellar region, who promptly responded to radiation therapy (2,500 cGy) with reversal of neurologic deficit. The disease recurred 2 years later and again promptly responded upon treatment to 2,000 cGy. Hepatic metastases were controlled for over 1 year with 3,240 cGy. The radiotherapy of pheochromocytoma and chemodectoma is reviewed, and the similarities between the two kinds of tumor are discussed. We speculate that a higher initial radiation dose might have resulted in a more sustained remission in our patient and recommend doses of 4,000-5,000 cGy if they can be safely administered, in 4-5 weeks for pheochromocytomas.

Adrenal Gland Neoplasms↗
PubMed1996

Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature.

BACKGROUND: Simple excision of earlobe keloids can result in recurrence rates approaching 80%. Many modalities have been suggested to reduce the risk of recurrence postoperatively, including intralesional steroids and radiotherapy. OBJECTIVE: In order to determine the most reliable method to prevent keloid recurrence, we have conducted the first randomized, prospective trial comparing corticosteroid injections versus radiation therapy. RESULTS: Thirty-one keloids were treated and followed for a minimum of 12.0 months. Two of 16 keloids (12.5%) recurred after surgery and radiation therapy, while 4 of 12 (33%) recurred after surgery and steroid injections. No alteration of skin pigmentation, wound dehiscence, chronic dermatitis, or neoplastic changes was observed in any patient in either group. Although a statistically significant difference was not observed, radiotherapy appeared to be more effective than steroid injections in preventing keloid recurrence. CONCLUSIONS: Radiotherapy is a simpler treatment modality with better patient compliance, and patients were much more likely to complete treatment than with corticosteroid injections. We believe that radiotherapy can play an important role in the prevention of earlobe keloid recurrences, and that with current techniques, complications can be minimized. Further randomized study with additional patients is needed to compare the effectiveness of corticosteroid injections and radiotherapy in preventing keloid recurrence.

Administration, Topical↗
PubMed1995

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Journal Article↗
PubMed1994

Randomized trial comparing preoperative versus postoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement: preliminary results.

PURPOSE: Previous in vivo data support effectiveness of preoperative irradiation in suppressing heterotopic ossification (HTO) in a rat model. A prospectively randomized, multiinstitution clinical trial to assess the comparative efficacy of preoperative vs. postoperative irradiation in preventing HTO in total hip replacement patients was undertaken. METHODS AND MATERIALS: One hundred and twenty-two patients (124 hips) with significant risk factors for HTO following elective total hip replacement were randomized to receive irradiation via either preoperative (< 4 h before surgery) or "standard" postoperative (< 48 h after surgery) schedules. Single 7-8 Gy fractions were administered. Treatment volume included soft tissues between periacetabular region of pelvis and intertrochanteric portion of femur. All but nine patients had biologic fixation prostheses, the porous-coated portions of which were shielded. Radiographs of treated hips were obtained immediately and at 2 and 6 months postsurgery. Heterotopic ossification was scored according to the Brooker Grading system. RESULTS: Ninety-eight patients are evaluable (55 preoperative, 43 postoperative) with median follow-up of 38 weeks. No significant differences were noted in the incidence of overall HTO (26% preoperative vs. 28% postoperative, p = 1.0) or clinically significant Brooker grade 3 or 4 HTO (2% preoperative vs. 5% postoperative, p = 0.58). No significant differences in treatment variables (including time interval between preoperative irradiation and surgery) were evident on comparing preoperatively treated patients forming HTO with those who did not. CONCLUSION: Prophylactic irradiation of the operative site within 4 h prior to elective total hip replacement appears to be comparably effective to the currently accepted postoperative treatment schedules in prevention of clinically significant HTO about the hip. This finding is of importance in terms of patient comfort, ease of treatment, and avoidance of possible complications associated with moving the patient to the radiotherapy department in the immediate postoperative period.

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