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Biomedical subjects

M Cedeño

Publications and source records attributed to M Cedeño.

6 recordsLinked to original sources
PubMed2004

Multiple dose toxicity study of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 intravenously administered to Cercopithecus aethiops sabaeus monkeys.

The h-R3 is a humanized growth factor receptor monoclonal antibody (mAb) in development for the treatment of head and neck tumours in which malignant cells overexpress the Epidermal Growth Factor receptor. The present study was designed to evaluate the toxicity of repeated intravenous doses of the h-R3 mAb in a relevant species demonstrated by the avidin-biotin-peroxidase immunohistochemical (IHC) technique in skin biopsy samples from three Cercopithecus aethiops sabaeus monkeys (green monkeys). Additionally, 18 green monkeys were daily intravenously treated during 14 consecutive days. Monkeys were distributed into three experimental groups with three animals of each sex in each group. Group I received saline solution and served as control group; group II received 2.85 mg/kg of h-R3 mAb; and group III received 11.4 mg/kg of the h-R3 mAb. During the study there were no deaths, neither pathological clinical signs, or variations in the corporal weight curve. The electroneurophysiological and sanguine chemistry results did not evidence alterations related to the assay substance. Areas of haematomas, haemorrhages and inflammation, probably related with the administration procedure, were observed at the administration zones of all animals; this fact could also explain the increase in the neutrophil count of all animals at the end of the study. The electrocardiography study showed that in the 14 days of the study one female monkey, from the higher dose group, shifted its cardiac axis from +60 degrees to + 120 degrees; this finding could be interpreted as a right ventricular elongation due to the relative high daily administered volume. It is concluded that doses up to 11.4 mg/kg of h-R3, intravenously administered during 14 consecutive days to Cercopithecus aethiops sabaeus monkeys do not produce considerable toxic effects in the studied system.

Animals↗
PubMed2000

Clusters of drug involvement in Panama: results from Panama's 1996 National Youth Survey.

This report is based on the first epidemiological investigation of clustering of tobacco, alcohol, inhalant, and other drug involvement within individual schools using data from Panama's 1996 National Youth Survey on Alcohol and Drug Use. Clustering was estimated with the Alternating Logistic Regression method. Adjusted estimates of pair-wise cross-product ratios (PWCPR), a measure of clustering, show modest clustering (i.e. PWCPR>1.0) at the school level for tobacco smoking (PWCPR=1.41; 95% confidence interval, CI=1.22-1.64), alcohol consumption (PWCPR=1.33; 95% CI=1.22-1.45), use of inhalants, (PWCPR=1.35; 95% CI=1.07-1.69), and other drug use (PWCPR=1.38; 95% CI=1.14-1.68). These findings provide preliminary evidence that the odds of drug use among school-attending youths increase when another youth in the same school uses drugs, and suggest a new line of research on within-school diffusion that should include the identification of school-level factors that contribute to student drug use.

Adolescent↗
PubMed1995

Tequila production.

Tequila is obtained from the distillation of fermented juice of agave plant, Agave tequilana, to which up to 49% (w/v) of an adjunct sugar, mainly from cane or corn, could be added. Agave plants require from 8 to 12 years to mature and during all this time cleaning, pest control, and slacken of land are required to produce an initial raw material with the appropriate chemical composition for tequila production. Production process comprises four steps: cooking to hydrolyze inulin into fructose, milling to extract the sugars, fermentation with a strain of Saccharomyces cerevisiae to convert the sugars into ethanol and organoleptic compounds, and, finally, a two-step distillation process. Maturation, if needed, is carried out in white oak barrels to obtain rested or aged tequila in 2 or 12 months, respectively.

Alcoholic Beverages↗
PubMed1985

[Evaluation model of the extra-mural program in nursing: cycle II, Colombia].

In Cali, Colombia, a study was done to test and apply a model for the evaluation of out-of-school training programs in nursing in comparison with classroom programs. The article describes the evaluation model, which starts with the admission factors, considers how they are changed in the process, and compares the results by measuring the effects obtained against the established objectives. The information on admission factors was obtained by means of a questionnaire on health, a survey of teachers, pairing tests for students, and records of input/cost ratios; the source of information on the process was the tests of academic performance in the three courses provided in the design, the evaluation forms, and the student records. The academic records, a survey of graduates and a form for monitoring nursing activities were the three instruments used to measure the effects of the program. The conclusion of the study was that the objectives of the program were attained. Tested experimentally, the model of out-of-school nursing training was found to offer instruction of quality that is helpful to the learning process. The evaluation of the process made it possible both to identify and to solve the curricular, learning and administrative problems. The learning modules have been adapted for the wider diversity of students brought in by expansion of the program. Meanwhile, the instruments for the collection of data for the evaluation have been simplified on the basis of the experimental study.

Colombia↗
PubMed1985

[Current participation of the nurse in the activities covered in the "expanded role of nursing"].

The article reports on a survey conducted in Colombia to evaluate the part played by the nurse in the functions covered by what has come to be called "the expanded role of nursing." According to the survey, there are 2,213 practicing nurses, who are clustered in the principal cities of the country. Those who participated in the study are young nurses holding staff positions in such institutions as university and social security hospitals. Their training is mostly at the university level, and they have had five years or less of experience. The article notes that, to perform the duties of the expanded role, the nurse must participate in accordance with her training, interest and motivation. The participation may be conditioned by factors in the nurse herself (prior knowledge, former training, previous participation, and responsibility) and by factors in the working environment (the person who instructed her on her role, the post she holds, her length of service/length of her work day, permission received from the institution to exercise her function, and the medical and nursing agreement). Parodoxically, the nurse is being made a participant in new functions at hospitals where there are medical resources and not in regions and places where those resources are scarce or nonexistent. The expanded role of nursing opens to the nurse a range of activities that enable her to provide quality care to the patient and to his or her family and community, to extend the coverage of health services, and offer treatment effectively.

Colombia↗