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Biomedical subjects

M Cattaneo

Publications and source records attributed to M Cattaneo.

At least 127 records · Page 7Linked to original sources
PubMed1989

[The measurement of ultradistal radial bone minerals in women in the menopause].

An anthropometric, radiomorphometric and absorptiometric study was carried out to check whether or not reliable information about the mineral content of trabecular bone could be acquired from the ultradistal epiphysis of the human radius. The results indicate that a radius scan 1.2 to 1.6 cm proximal to the ulnar styloid tip gives reproducible information as to the mineral content of a bone which is mainly trabecular in nature. In the ultradistal radial region the bone mineral analyzer (Norland 2780) was always able to automatically find bone edges. The measurement error was 4%, and BMC values were not significantly different in the various subjects; BMC values were positively correlated with body mass and muscular area in postmenopausal women. Conversely, in no subject a direct correlation was found between BMC and BW values at sequential scan sites; BMC/BW ratios were more than 10% variable, and the differences were statistically significant (p less than 0.01). Finally, the comparison of age-related changes in the BMC of ultradistal and mediodiaphyseal radii demonstrated that the former expresses the specific metabolic reactivity of the trabecular bone.

Absorptiometry, Photon↗
PubMed1988

Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway.

We have studied the interaction of ASvWf with human platelets in PRP and in suspensions of washed platelets containing either physiological or low external ionized calcium concentration [Ca2+]o. In hirudin-PRP or in washed platelets in 1.5-2 mM CaCl2, ASvWf up to 50 micrograms/ml does not induce platelet aggregation or the release reaction. When [Ca2+]o is decreased by addition of citrate to hirudin-PRP or when no CaCl2 is added to washed platelet suspensions, ASvWf does induce platelet aggregation and the release reaction. In low [Ca2+]o, ASvWf interacts with platelet GPIb to cause primary aggregation of disc-shaped platelets to each other through GPIIb/IIIa, with or without added fibrinogen. This primary platelet aggregation leads to thromboxane A2 formation and secondary aggregation and the release reaction. With [Ca2+]o in the physiological range, there is less ASvWf interaction with GPIb, no primary platelet aggregation and no thromboxane A2 formation. The ASvWf-platelet interaction at physiological [Ca2+]o, however, enhances the platelet response to collagen or epinephrine.

Arachidonic Acids↗
PubMed1987

Improvement in the haemostatic defect of uraemia after treatment with recombinant human erythropoietin.

Patients with uraemia have a defect of primary haemostasis expressed as long skin bleeding times and reduced platelet adhesion to the arterial subendothelium. Transfusion of red cells shortens the bleeding time and stops bleeding symptoms in uraemia. This study investigated whether the efficacy of recombinant human erythropoietin in correcting anaemia and the improvement in haemostasis are correlated. Recombinant human erythropoietin was given to seven consecutive patients with chronic uraemia, a history of bleeding, severe anaemia (haematocrit below 23%), and long bleeding times (above 19 min). The progressive rise in haematocrit induced by increasing doses of recombinant human erythropoietin was paralleled by a pronounced shortening of the bleeding time. Platelet adhesion to the subendothelium of human umbilical arteries, very low before the study, increased greatly in all patients and became normal in six. None of the patients bled during the study period.

Adult↗
PubMed1987

In vitro and ex vivo effects of indobufen on human platelet aggregation, the release reaction and thromboxane B2 production.

We have done a comprehensive study in normal volunteers of the in vitro and ex vivo effects of the antiplatelet agent indobufen on platelet aggregation, the release reaction and thromboxane B2 (TxB2) production as induced by different concentrations of aggregating agents. At low concentrations (10 microM), indobufen completely inhibited secondary platelet aggregation, the release reaction and TxB2 production stimulated by ADP, epinephrine and low concentrations of platelet-activating factor (PAF acether). Higher concentrations of indobufen (100 microM) completely inhibited TxB2 production, platelet aggregation and ATP release induced by arachidonic acid (1 mM) or collagen (2 micrograms/ml). The inhibitory effect was partially overcome by higher concentrations of arachidonic acid (2 mM). Data obtained ex vivo 2 h after the oral administration of 200 mg indobufen to 8 normal volunteers were in keeping with those of the in vitro study. We conclude that indobufen inhibits platelet aggregation and the release reaction by inhibiting the platelet arachidonate pathway.

Adenosine Triphosphate↗
PubMed1987

Cardiac relapses in myeloid leukemia: case report and review of the literature.

Granulocytic sarcoma (GS) is a localized destructive tumor mass composed of immature cells of the granulocytic series, occurring before, concomitantly, or after the overt development of acute or chronic myelogenous leukemia. Although this tumor is known to occur in almost every site of the body, cardiac involvement is rare. We report a case of a 12-year-old female previously treated for 28 months with chemotherapy for acute promyelocytic leukemia, who presented with GS in the left mastoid 3 months after discontinuing treatment. The patient was treated with local radiotherapy only. Thirty months later she presented with heart failure, the result of a right-sided intracardiac mass, while in continuous hematological remission of the primary disease and off therapy. The cardiovascular, hematological, and postmortem findings are described and the literature is reviewed. This is the first clinicopathologic report of GS involving the heart in which the echocardiographic and pathologic findings are detailed.

Cardiomyopathies↗
PubMed1987

A comparative study on peripheral blood lymphocyte subpopulations in different kinds of warts.

Peripheral blood T-cell subpopulations were evaluated in 36 patients with clinically different types of warts, subdivided in 4 groups (common, genital, flat and plantar warts). A significant decrease was found in OKT3 and OKT4 subsets total count and in OKT4/OKT8 ratio in patients with common and genital warts as compared with controls. Only in common and genital warts did we also observe a significant decrease of percentage of OKT4 subset. No significant difference of considered parameters was observed in flat and plantar warts as compared to controls, apart from a significant increase in number of OKT8 subset in flat warts. We then discuss this different status of C.M.I. in patients with different clinical warts, stressing the importance of various types of HPV.

Adolescent↗
PubMed1987

Fibrinogen-independent aggregation and deaggregation of human platelets: studies in two afibrinogenemic patients.

Platelets from two afibrinogenemic patients were used to determine whether fibrinogen is essential for platelet aggregation and to examine whether released fibrinogen contributes to the stabilization of platelet aggregates when platelets have been induced to aggregate and release their granule contents by stimulation with thrombin. The addition of adenosine diphosphate (ADP) to platelet-rich plasma (PRP) or to suspensions of washed platelets from the afibrinogenemic patients caused the formation of small aggregates, which was either not inhibited or only slightly inhibited by the F(ab')2 fragments of an antibody to fibrinogen but was inhibited by an antibody (10E5) to glycoprotein IIb/IIIa. Thus there is a component of ADP-induced platelet aggregation that is not dependent on fibrinogen or other plasma proteins but is dependent on glycoprotein IIb/IIIa. There was little difference in the extent of aggregation and the release of granule contents of normal and afibrinogenemic platelets in response to the release-inducing agents collagen, platelet-activating factor (PAF), sodium arachidonate, or thrombin. With normal or afibrinogenemic platelets, aggregation by thrombin (0.2 U/mL or higher) was not inhibited by the F(ab')2 fragments of an antibody to human fibrinogen. Deaggregation by combinations of inhibitors of platelets aggregated by 1 U/mL thrombin showed no difference between platelets from afibrinogenemic and control subjects, indicating that released fibrinogen does not make a major contribution to the stabilization of platelet aggregates formed by thrombin stimulation.

Adenosine Diphosphate↗
PubMed1987

Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets.

To investigate the suggestion that von Willebrand factor (vWf) can substitute for fibrinogen in supporting ADP-induced aggregation of human platelets, we studied platelet reactions in two media: (1) a high calcium medium, Tyrode-albumin solution containing calcium ions in the physiological range of 2 mmol/L, and (2) a low calcium medium, modified Tyrode-albumin solution from which calcium salt was omitted (calcium ion concentration approximately 20 mumol/L). In the high calcium medium vWf even at concentrations up to six times as high as physiological, showed little or no potentiation of ADP-induced platelet aggregation, whereas fibrinogen strongly potentiated reversible aggregation without thromboxane formation or release of granule contents. In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Aspirin and the thromboxane receptor blocker BM 13.177 inhibited these secondary responses to von Willebrand factor, indicating that they require thromboxane A2 formation and feedback amplification by thromboxane A2. A monoclonal antibody, 10E5, to the platelet glycoprotein IIb/IIIa complex inhibited both primary and secondary aggregation. Although vWf supports ADP-induced aggregation when the concentration of ionized calcium is in the micromolar range, it does not support ADP-induced aggregation in the presence of a concentration of ionized calcium in the physiological range, indicating that vWf probably cannot substitute for fibrinogen in supporting ADP-induced aggregation in vivo.

Adenosine Diphosphate↗
PubMed1987

Evaluation of efficacy and tolerability of K-FA fluocinolone acetonide tape.

In order to assess the efficacy and tolerability of a fluocinolone acetonide tape (8 micrograms/cm2), 30 volunteer out-patients, 11 females and 19 males, mean age 43.4 years, affected by different kinds of dermatoses were treated. The tape was applied once or twice daily for an average period of 9.3 days. At the beginning and the end of the treatment, detailed dermatological and blood chemistry examinations were performed in all the patients. The clinical results were excellent for all the dermatoses treated. Itching at the site of application was reported by two patients and slight atrophy was observed in one patient. The patients' compliance was excellent. The blood chemistry tests showed no significant variation.

Administration, Cutaneous↗
PubMed1987

Allergy to house dust and storage mites in children: epidemiologic observations.

One hundred and fifty-two children affected by respiratory syndromes, probably due to allergy, underwent skin testing to a range of extracts including several different species of mites. The incidence of positive reactions to different allergens was studied in two groups: below and over 4 years, each including both outpatients and inpatients. The aetiologic role of mites has been evaluated considering positive skin tests to single species between and within families.

Animals↗
PubMed1986

[Psoriasis and day hospital. Clinical and therapeutic considerations concerning 104 cases].

One hundred and four patients with psoriasis, treated in regimen of Day Hospital, have been examined. The diagnosis was widespread plaque type psoriasis (67.3%), guttate psoriasis (18.3%) and nail psoriasis (1.0%). Furthermore psoriatic erythroderma has been observed in 2.9% and pustular psoriasis of Barber in 1.9%. 10% of the patients showed psoriatic arthritis. 71.2% of the patients have been successfully treated with UVB and PUVA irradiation therapy (respectively 86.6% and 70.0% of complete clearing or marked improvement). Etretinate and topical therapy were successful (respectively 67.0% and 70.0% of complete clearing or marked improvement). Day Hospital has proved to be the ideal regimen for the treatment and control of psoriatic patients.

Administration, Topical↗
PubMed1986

[Sexually transmitted infections in patients with condylomata acuminata].

42 patients (26 males, 16 females) with genital and perianal warts were submitted to serological testing for HBV markers, anti HSV antibodies and syphilis. Specimens were also collected for microscopic and cultural examination for Neisseria gonorrhoeae, Chlamydia Trachomatis, Trichomonas vaginalis, Candida albicans and other pathogenic bacteria from urethra in men and from urethra, vagina and cervix in women. Women had also cytologic examination from cervix with Papanicolau method. We have found an high incidence of urethral and vaginal asymptomatic infections, of positivity for HBV markers and some positivities of tests for syphilis. Importance of these screening examinations in the management of patients with genital warts is then discussed.

Adult↗
PubMed1986

Fibrinogen Milano II: a congenital dysfibrinogenaemia associated with juvenile arterial and venous thrombosis.

A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagulase complex. Analysis of the fibrinopeptides A and B by High Performance Liquid Chromatography did not reveal an abnormal peptide structure. The rate of release of A and B peptides by thrombin was strongly delayed, whereas the rate of release of fibrinopeptide A by Arvin appeared to be normal. The fibrin polymerization rate was normal. Interactions between the abnormal fibrinogen, platelets and the fibrinolytic system were also normal. Evidence is presented that the defective interaction between fibrinogen Milano II and thrombin is associated with a defective binding of thrombin to the fibrin moiety of the abnormal fibrinogen.

Adult↗