Search PubMed⌕ Search

Biomedical subjects

M Castro-Gago

Publications and source records attributed to M Castro-Gago.

At least 91 records · Page 5Linked to original sources
PubMed1987

Effects of chronic allopurinol therapy on purine metabolism in Duchenne muscular dystrophy.

Adenine, adenosine, inosine, hypoxanthine, xanthosine, xanthine, guanine and guanosine blood levels in 11 Duchenne muscular dystrophy patients treated with allopurinol, 10 untreated patients and 8 healthy controls, were determined by HPLC. Serum ADA, PNP and 5'-NT were also determined. Untreated patients showed lower adenine (p less than 0.001) and higher adenosine, xanthine, ADA and PNP levels (p less than 0.01) than controls. Treated patients had lower adenine and higher xanthine levels (p less than 0.001), but higher hypoxanthine, xanthosine and guanine levels (p less than 0.001), than controls, with normal ADA and PNP. The changes observed in ADA and PNP levels suggest an involvement of these enzymes in accelerated degradation of purines in Duchenne dystrophy.

5'-Nucleotidase↗
PubMed1987

[Treatment of neurogenic bladder secondary to myelomeningocele based on the urodynamic status with intermittent catheterization associated with drugs. Preliminary results].

The follow-up of 36 children with neurogenic urinary bladder, aged from 3.5 months to 12 years is reported. The were serially evaluated with tonometry of detrusor muscle and urethral sphincter. Management consisted in drugs (anticholinergics, alpha-adrenergic agonists and antagonists) associated with intermittent vesical catheterization in different combinations determined by starting urodynamic measurements. With this treatment control of micturition or frank improvement was reached in 91.6% of patients, urodynamic explorations normalized or improved in 94.3% and recurrent urinary infections persisted only in 13.8%. At the view of these results authors believe that treatment of neurogenic bladder secondary to myelodysplasia must be closely dependent on previous urodynamic evaluation.

Child↗
PubMed1987

[Drug-induced extrapyramidal syndrome. Apropos of 22 cases].

We present extrapyramidal syndrome in 22 children (5 en 1984 and 17 during 1985) who received clebopride (15), metoclopramide (6) and haloperidol (1), almost all at the level of therapeutic doses, which fact seems to indicated a idiosyncratic factor. Symptoms occurred after 2.36 +/- 1.49 doses (mean+/- SD), and the most frequent was: dyskinetic movements (45.5%), oculogyric crisis (40.9%), uneasiness (40.9%) and hypertonic reaction (36.4%). The symptoms disappeared in all patients after drug administration was stopped and therapy with diphenhydramine or biperiden intravenously.

Adolescent↗
PubMed1986

The concentrations of xanthine and hypoxanthine in cerebrospinal fluid as therapeutic guides in hydrocephalus.

Xanthine, hypoxanthine, and total oxypurine levels were determined in the cerebrospinal fluid of 18 hydrocephalic patients and 8 healthy controls by high-performance liquid chromatography (HPLC). Eight of the hydrocephalic patients were self-compensated and 10 had shunts implanted during the course of the study. The mean xanthine, hypoxanthine, and total oxypurine levels in the normal children were 5.20, 5.94 and 11.29 mumol/l, respectively. In self-compensated hydrocephalics these levels were respectively 6.06, 6.50 and 12.57 mumol/l. In noncompensated hydrocephalics, they were 11.40, 10.79 and 22.19 mumol/l. The differences between the latter group and the first two are statistically significant (P less than 0.001). Fifteen days after implantation of shunts in the noncompensated hydrocephalics, the mean xanthine levels had fallen to 4.61 mumol/l, the mean hypoxanthine levels to 5.03 mumol/l, and the mean total oxypurine levels to 9.64 mumol/l. The change is statistically significant (P less than 0.001). In light of these findings we propose that xanthine, hypoxanthine, and total oxypurine levels be used in cases of hydrocephalus as guides for therapeutic action and to monitor progress.

Cerebrospinal Fluid Shunts↗
PubMed1985

Glucocorticoid deficiency with achalasia of the cardia and lack of lacrimation.

Four recent reports describe a multisystem disorder in which ACTH insensitivity is associated with achalasia and alacrima. We report studies on a male patient with this rare triad. The patient had alacrima from birth; isolated glucocorticoid deficiency had been diagnosed at 3.5 years of age and achalasia at age 6. The possibility that this syndrome could be due to a parasympathetic degeneration has already been proposed; the cause of the glucocorticoid deficiency, however, remains unclear. Parasympathetic function in other areas was investigated to determine whether there might be a more generalized abnormality. Specific cardiac tests of parasympathetic function showed that parasympathetic input to the heart was affected in the patient, while the same tests in an Addisonian child were normal. We show, then, a hitherto undetected parasympathetic abnormality in a patient with this syndrome, suggesting a generalized disturbance of this system. On this basis we may hypothesize that the glucocorticoid failure may be a consequence of the loss of parasympathetic input to the adrenal gland, although this remains to be demonstrated experimentally.

Acetylcholine↗
PubMed1985

[Comparative study between CPK, LDH and their isoenzymes in the detection of carriers of Duchenne's type muscular dystrophy].

Results of a comparative study of serum activity levels of creatine kinase, lactodehydrogenase and their isoenzyme in mothers of 13 children with Duchenne progressive muscular distrophy are presented. CPK sensibility was 100%, while that of LDH1/LDH2 and LDH5 were 23% and 38,4% respectively. It is concluded that CPK has a great liability index, and that it is superior to LDT and their isoenzyme for detection of carriers of Duchenne progressive muscular distrophy.

Adult↗
PubMed1983

[Familial syndrome of microcephaly with oculocutaneous albinism and digital anomalies].

Authors make a report concerning a male patient who presents microcephaly, oculocutaneus albinism, hypoplasia of the distal phalanx of the 1st, 3rd and 4th finger of the right hand, 1st, 3rd, 4th and 5th finger of the left hand and agenesia of the distal end of the big toe of the right foot. They think it is a new dysmorphic syndrome. Because of patient's sister presented a similar picture they suggest that it may be an autosomal recessive inheritance pattern.

Abnormalities, Multiple↗
PubMed1982

Ectopic production of ACTH by Wilms' tumor.

The authors present the 2nd documented case of Wilms' tumor associated with the "ectopic ACTH syndrome'. This is a 7 1/2-year-old girl who, on examination at the time of admission, had the classical cushingoid appearance. A large hard mass was palpable in the right side of the abdomen. Hormonal assays were consistent with Cushing's syndrome; the serum ACTH levels were extremely high. After surgical removal of the mass, we suspected a stage I Wilms' tumor; this was confirmed by histopathological studies. After surgery, the girl quickly lost her cushingoid appearance and weight excess. Postoperative serum ACTH levels were normal. Ectopic hormone syndromes associated with tumors in childhood are discussed as well as the possible mechanism involved in the ectopic production of ACTH.

Adrenocorticotropic Hormone↗
PubMed1982

[C-reactive protein. Value in diagnosis of infectious complications of hydrocephalus children with shunt (author's transl)].

The C-reactive protein, leukocytes count and erythrocyte sedimentation rate, were determined in 32 hydrocephalus children treated with shunt, on the 1st day, 5th day and 10th day postintervention. C-reactive protein was positive on the 5th day postintervention in the 66.6% of the patients with infection and the 100% of these patients on the 10th day. In three patients C-reactive protein was the first sign of infection. In 33.3% of the patients with infectious complications, C-reactive protein positive was earlier than leukocytes and erythrocyte sedimentation rate abnormalities. From these findings, authors suggest C-reactive protein as valuable test in the postoperative control of the hydrocephalus children and should alert to the possibility of a infectious complication.

Blood Sedimentation↗
PubMed1982

[Determination of the mean dose of oral theophylline in asthmatic children (author's transl)].

The oral dosage of theophylline was adjusted in order to maintain a serum level between 10 and 20 micrograms/ml. in a group of 53 children whose ages were less tha nine years. A plan of regular increments with a maximal dosage reduced to 18.5 mg./kg./day was followed, with advantageous results. The necessary medium dosage was 18.4 +/- 2.7 mg./kg./day. This dosage didn't have statistically significant difference with that obtained previously by us (18.4 +/- 4.0) in a group of 46 children of comparable age but, by contrast, it had a statistically significant difference when compared with the dosage (24.1 +/- 5.5) obtained by another medical teams working with american children of similar age. After a fruitless search of known causes that could explain these differences, we think in the possibility of genetical and/or unknown environmental influences.

Administration, Oral↗