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Biomedical subjects

M Casanova

Publications and source records attributed to M Casanova.

At least 127 records · Page 7Linked to original sources

[Current status of objective measurements of nasal airflow].

Objective quantitative measurements of nasal airway patency are badly known and used in clinical practice. However lot of difficulties may be overcame. The modern instruments have a good preciseness and the results are given with reproducibility. The authors sum up principal indications, wether medical or surgical, and insist on a necessary severe methodology.

Humans↗

[Bacteriological study of maxillary sinusitis].

Suppurated maxillary sinusitis are frequent diseases. Diameatic puncture allows bacteriological investigations. Our results are positive in two thirds of cases. The bacterial flora is very varied, whose identification and antibiograms involve efficient treatment with daily washing and in situ antibiotherapy.

Adolescent↗

Esophageal and duodenal approach for testing duodenogastric reflux in dogs.

A modified Komarov-Marks esophagostomy is described. It was the aim of our experiments to show that this procedure does not harm the vagal innervation of the stomach. The vagal function was assessed by testing (1) basal secretion, (2) 2-deoxy-D-glucose-stimulated secretion, (3) pentagastrin-stimulated secretion, and (4) serum gastrin levels in five mongrel dogs. Each test was performed at least three times in each dog before and after the esophagostomy procedure, respectively. The secretion rates were not affected by surgery. It is concluded that cervical esophagostomy in dogs does not affect vagal stimulation of gastric acid secretion. For the application of tracer substances into the duodenum, two types of conduits are described: (1) a short jejunal segment and (2) a jejunal segment with an invagination valve. The pros and cons of these procedures are discussed.

Animals↗

[Fever of undetermined origin in a case of total correction of persistent truncus arteriosus with agenesis of the left pulmonary artery (author's transl)].

A 19 month-old girl diagnosed of truncus arteriosus with absence of the left pulmonary artery and severe truncal valve insufficiency underwent total correction. A non previously diagnosed severe mitral insufficiency required a new operation to implant a Bjork-Shiley supraanular mitral prosthesis. The postoperative period was hemodynamically normal, except for the presence of persistent fever of unexplained origin. The clinical picture was thought to be an infectious endocarditis due to the late appearance of an aortic prosthetic leak. Because of failure to medical treatment a reoperation was performed to replace aortic prosthesis. Patient died eight hours postoperatively. Autopsy revealed a correct surgical repair, absence of endocarditis and severe miliary disseminated tuberculosis. Authors consider of interest to present this case-report due to the rarity of: a) correction of truncus with a single pulmonary artery under two years of age; b) associated mitral insufficiency; c) the presence of tuberculosis, difficult differential diagnosis with infectious endocarditis in a patient with valvular prosthesis.

Aortic Valve↗

[Continent external duodenal fistula in the dog (author's transl)].

An established method for the experimental approach to the duodenum in the dog is the interposition of a segment of small bowel. However, the leakage of intestinal fluid causes unpleasant side effects. By the invagination within the intestinal segment as valve can be constructed which provides both continence and easy access.

Animals↗

[Delay of early rejection of intrasplenic pancreatic allotransplants by fractional splenic irradiation in dogs (author's transl)].

The influence of local irradiation of the spleen and immunosuppressive drugs (cyclophosphamide and azathioprine) on the rejection of intrasplenic pancreatic allotransplants was studied. Fractional splenic irradiation (once 4000-5000 rad before, twice 500-1000 rad after transplantation) prolonged transplant function from 4,1 to 6,5 days, in combination with immunosuppressive therapy to 8,5 days.

Animals↗

[Complete triploidy in a liveborn premature (author's transl)].

Authors describe the clinical, pathological and cytogenetic data of a polymalformed premature with a complete a triploidy 69,XXY). This rare condition (30 cases in the literature) may be suspected in a premature with broad posterior fontanella, eye and ear anomalies, syndactily between IV and III fingers/toes, intersexual status and mielomeningocele. Frequently the placenta presents a molar or micromolar degeneration.

Abnormalities, Multiple↗

Familial hypertrophic cardiomyopathy with unusual involvement of the right ventricle.

4 cases of familial hypertrophic cardiomyopathy are reported. In all of them, the onset of symptoms occurred before the 8th mth of life, and were characterized by severe right cardiac failure. In 3 cases the catheterization revealed significant decrease in right ventricular compliance and severe reduction of its cavity. The pathological studies were consistent with hypertrophic cardiomyopathy with predominant involvement of the right ventricle. The pedigree disclosed a Mendelian autosomal recessive type of inheritance.

Cardiomyopathy, Hypertrophic↗

Prenatal identification of a Y-chromosome deletion by Y-specific single copy DNA probes.

A sex chromosome deletion was identified in the course of prenatal diagnosis for maternal age. Ultrasound pictures revealed male fetal sex and a comparison with the father's Y chromosome suggested that the altered chromosome might be a de novo deletion of the Y chromosome. DNA hybridization with five human Y-specific probes shows that, among the Y-specific sequences recognized by the probes, only two of them are absent. The normal infant, at birth, was mosaic 46, XYq-/46,XY.

Adult↗