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Biomedical subjects

M Carroll

Publications and source records attributed to M Carroll.

At least 181 records · Page 10Linked to original sources
PubMed1973

Immunological properties of N-acetyl-beta-D-glucosaminidase of normal human liver and of GM2-gangliosidosis liver.

Antisera were raised to a partially purified preparation of human liver hexosaminidase and to highly purified preparations of hexosaminidase isoenzymes A and B. All the antisera precipitated the enzyme in an enzymically active form, which could be located on immunodiffusion and immunoelectrophoretic gels by using a histochemical substrate. The antisera to the purified isoenzymes were shown to react with hexosaminidase from human liver, kidney, brain and spleen, but did not cross-react with human liver beta-glucosidase, beta-galactosidase, alpha-mannosidase, beta-xylosidase, arylsulphatase or acid phosphatase. Hexosaminidases A and B were immunologically identical. The immunological properties of the hexosaminidases from livers of patients with three types of GM(2)-gangliosidoses were closely similar. No evidence could be found for cross-reacting material in enzyme-deficient states.

Acetamides↗
PubMedDate not supplied

Instructions for ambulatory surgery--patient comprehension and compliance.

Ambulatory surgery has proliferated as a result of increasing inpatient costs. Its high level of safety has resulted in its extension to less healthy, often elderly patients. Patient compliance with instructions is essential to avoid morbidity. We aimed to identify subgroups potentially at risk due to non-compliance. A confidential questionnaire was administered to 220 consecutive daycase patients. Data included: patient demographics, duration of fasting, taking of medications that morning, importance of fasting and medication instructions, mode of post-discharge transport, and whether they had someone to stay with them that night. Seven (3.5 per cent) patients admitted to non-compliance with fasting instructions, with 8 per cent considering these instructions non-essential. Thirteen of 59 patients on medications took them against instructions, with 9 patients considering the instructions non-essential. Eight patients admitted intending to drive home; 7 per cent admitted to having no one to stay with them on the night of surgery. A significantly minority of patients (particularly male) admit to non-compliance with ambulatory surgery instructions; these figures may be underestimates. Absence of anaesthetic/medical input and lack of reinforcement probably contribute to non-compliance. Some medication-related non-compliance may be appropriate (e.g. antianginals, antihypertensives) and may reflect conflicting instructions given to the patient. The stopping of all medications prior to ambulatory surgery needs revision. Older patients living alone may not be suitable candidates for ambulatory anaesthesia.

Adolescent↗
PubMedDate not supplied

Patient attitudes to perioperative suppository administration for postoperative analgesia.

Four hundred surgical patients were questioned preoperatively to ascertain their attitudes to suppository analgesia. Given a choice, 82 per cent of patients expressed a preference for intramuscular administration of diclofenac, with 18 per cent choosing a suppository. Males were more likely than females to choose an intramuscular injection. Males choosing a suppository were more likely to belong to a higher socio-economic group while females choosing a suppository were more likely to be married. Twenty-three per cent of patients who initially opted for intramuscular administration changed to suppository administration when the possibility of pain or discomfort at the injection site was explained. Females who changed to suppository administration were more likely to belong to a higher socio-economic group and to be married. Twenty-seven per cent of patients choosing an intramuscular injection expressed concern if a suppository were to be inserted without consent. Eleven per cent of patients choosing a suppository expressed similar concern. There is an overall reluctance, particularly within the male population to accept suppository analgesia. Patients from higher socio-economic groups may be more willing to accept what they perceive to be less traditional forms of treatment.

Analgesia↗