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Biomedical subjects

M Calvani

Publications and source records attributed to M Calvani.

132 records · Page 8Linked to original sources
PubMedDate not supplied

Effects of propionyl-L-carnitine topical irrigation in distal ulcerative colitis: a preliminary report.

BACKGROUND/AIMS: To study the tolerability of propionyl-L-carnitine administered as rectal irrigation and its efficacy in improving the clinical picture of distal ulcerative colitis. METHODOLOGY: Ten male subjects (aged 18 to 55 years, with a body mass index ranging from 21 to 25 Kg/m2) with distal ulcerative colitis were treated with propionyl-L-carnitine enemas (6 g in 200 mL physiological solution) twice a day over 120 minutes each. All subjects had a disease activity index from 0 to 1. A clinical, laboratory, endoscopy and biopsy evaluation was performed at baseline and 14 days after treatment. Serum tumor necrosis factor-alpha and interleukin-2 concentration was measured. RESULTS: No side effects were reported by the entire patient population and the clinical conditions remained constant throughout the study period. The disease activity index improved significantly between the beginning and the end of the study in 80% of the patients. Histologic features (mucosal erosion, distortion of crypt architecture, inflammation and lamina propria gap) significantly improved in all treated patients. Serum interleukin-2 levels did not change significantly after propionyl-L-carnitine treatment (respectively: 14.7 +/- 15.8 before vs. 9.9 +/- 13.2 pg/mL), while tumor necrosis factor-alpha levels were undetectable both before and after propionyl-L-carnitine administration. CONCLUSIONS: The topical treatment with a new formulation containing propionyl-L-carnitine seems to be safe and effective in improving the histologic features in patients with inactive or mild ulcerative colitis, as an alternative to conventional therapy.

Adult↗
PubMedDate not supplied

[Anti-endomysium antibodies: a new marker for the diagnosis and treatment of celiac disease].

Coeliac disease is the most frequent cause of chronic diarrhea (1:1000 children) in Italy. It often has atypical symptoms, so a sensitive and specific test is needed that can both simplify the ESPGAM criteria and monitor compliance of patients to their gluten free diet. The AEmA (anti endomysium antibody), found by Chorzelsky in 1984, appears to be a very sensitive and specific screening test in the diagnosis of coeliac disease (CD). Sera from 150 children, mean age 4 years (range 6 months to 20 years) were tested for endomysium antibodies (IgA class) and anti gliadin antibodies (IgG class). From our preliminary study IgA-AEmA seem to be more specific for CD than IgG class anti-gliaadin antibodies.

Adolescent↗
PubMedDate not supplied

[Rheumatic fever in childhood--today].

Acute rheumatic fever in the young: a review of historical land marks and the current status of rheumatic fever are discussed. The follows are presented here: prevent-day epidemiology; the role of group A streptococcus and the reappearance of "rheumatogenic" serotypes; the host's susceptibility and the tantalizing possibility of a genetic basis; the basis of autoimmune pathogenesis (so-called molecular mimicry); the increasing diagnostic difficulties and the critical review of Jones criteria; the reassessment of primary prevention and the couvent possibility of a streptococcal vaccine.

Child↗
PubMedDate not supplied

[Cerebral vasculitis in children].

Vasculitis is the predominant feature of a large number of diseases in childhood. Cerebral vasculitis are quite common and sometime misinterpreted. They can be to express the direct vascular damage caused by the bacterial, viral, mycotic and protozoal agents; otherwise they can be to arise from some type of immunopathology including the presence of circulating immune complexes, or the prevalent defect of the T-Cells, or else still not well-know. The histological anatomy will to display the leukocytoclastic vasculitis or the granulomatous arteritis, and often will to make clear the pathogenetic's doubts of the clinical features. That is of the paramount importance for the very quick and correct therapy.

Adolescent↗
PubMedDate not supplied

[Deep venous thrombosis and the prevention of a pulmonary embolism with temporary caval filters: the experience in 2 pediatric cases].

Deep venous thrombosis with pulmonary embolism is considered rare in pediatric population, but a literature review points out this disease more frequent than would be expected in children. The low incidence and the poor consideration of this occurrence in pediatric age group, cause the thromboembolic disease with pulmonary involvement an often missed diagnosis. The illness is usually related to intravenous catheters, surgery, trauma, sepsis, prolonged immobilization, neoplasia, drugs, some congenital or acquired diseases. The Authors report their experience with two pediatric cases of inferior vena cava thrombosis and pulmonary embolism treated with anticoagulant therapy, temporary vena cava filters and locoregional fibrinolysis.

Adolescent↗