Biomedical subjects
Publications and source records attributed to M Cais.
A new method is described for the separation of free and bound fractions in a cannabinoid (3H)-radioimmunoassay without the need for centrifugation. The method employs a novel separation device which allows all manipulations to be performed in a single tube simply, rapidly and safely.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The newly synthesized 2-[203Hg]-estradiol-17 beta and 4-[203Hg]-estradiol-17 beta were injected into Fischer female rats bearing transplanted mammary adenocarcinomas and into Sprague-Dawley female rats bearing spontaneous mammary tumors. Four days after injection, tumor to blood ratios (and uterine to blood ratios) in the various groups were between 5 and 14, compared to a ratio of unity observed in normal mammary glands. When injected into male rats, the accumulation of 4-[203Hg]-estradiol in the prostate and in the epididimis was very low. With minute doses of 4-[203Hg]-estradiol injected into healthy male rats, the whole-body retention of the drug was found to decrease exponentially with time, and biphasic first order kinetics were observed. With pharmacological doses of the same drug, the clearance exhibited a biphasic pattern.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.