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Biomedical subjects

M C Robson

Publications and source records attributed to M C Robson.

At least 181 records · Page 10Linked to original sources
PubMed1978

Prevention of dermal ischemia after thermal injury.

One percent methylprednisolone acetate was evaluated as a pharmacologic agent in the prevention of dermal ischemia following burning. Standardized partial thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into five groups; one was treated with topical steroid, one with systemic steroid, one with both, one with emollient base without steroid, and one served as an untreated control. Histology and depth of dermal ischemia were evaluated by india ink perfusion technique. Untreated controls showed progressive dermal ischemia with complete absence of india ink-filled vessels in the dermis by 24 hours. Topical steroid alone improved dermal perfusion as suggested by relative levels of india ink filling. Topical steroid in the dosage used does not potentiate infection in standard burn wound sepsis models. Preservation of dermal appendages was seen secondary to improved dermal microcirculation with a ninefold increase in hair follicles in treated guinea pigs compared with controls.

Administration, Topical↗
PubMed1978

Experimental flap delay with formic acid.

Using dorsal, cranially based 10 X 3 cm composite pedicle flaps in rats, the effects of an injection of 2 ml of formic acid in different concentrations was studied. Concentrations of 0.2 per cent gave a very significant increase in flap survival over controls. Preoperative penicillin did not influence the outcome.

Animals↗
PubMed1978

Conservation of normal tissue in the treatment of massive basal cell carcinoma.

Reconstruction of a defect of the shoulder and chest wall following resection of extensive basal cell carcinoma is demonstrated using classic principles of flap design and delay. Preservation of the normal tissue in an arm before amputation allowed for closure of a wound that could not be covered with musculocutaneous, omental, or microvascular free flaps.

Amputation, Surgical↗
PubMed1978

Neurilemmoma presenting as a tumor in the tail of the parotid.

We describe our experiences with 8 patients who had expanding neurilemmomas of the posterolateral parotid area. Treatment is surgical dissection of the encapsulated tumor mass from its nerve of origin, under magnification, with preservation of that nerve and removal of the mass.

Adult↗
PubMed1978

Denervation supersensitivity and the delay phenomenon.

We have reviewed the denervation supersensitivity-AV shunt hypothesis (explaining the delay phenomenon) and assessed the contribution of each of the two components of denervation supersensitivy to delay. We concluded that adrenergic denervation supersensitivity contributes little to the delay phenomenon. We propose a new hypothesis, based on the effects of prolonged vascular smooth muscle relaxation in the precapillary arterioles, to explain the delay phenomenon.

Animals↗
PubMed1978

Preventing the prostaglandin effect on dermal ischemia in the burn wound.

The eventual depth of tissue necrosis after burning is not immediately apparent. In all burn wounds, there exists a zone of stasis which shows progressive microvascular deterioration. These progressive changes have been prevented by methylprednisolone acetate, indomethacin, and ASA. All of these agents are known to inhibit prostaglandin synthesis. These data suggest that prostaglandins have a role in the progressive dermal ischemia after thermal trauma and that their effect can be prevented by specific antiprostaglandins.

Animals↗
PubMed1977

The diabetic foot: an alternative approach to major amputation.

Of the complications of diabetes mellitus, none is more devastating than gangrene of the foot and the threat of leg amputation. The pathophysiology of vascular insufficiency, neurotrophic changes, and infection leading to this gangrene have been reviewed. Based on this pathophysiology, an approach for conservative surgery of the diabetic foot has been outlined. Using known principles of wound healing and the management of soft tissue infection, obviously necrotic or infected tissue is debrided and the wound managed conservatively. The use of debriding adjuncts such as the pulsating jet lavage, topical antibacterials, and biologic dressings are suggested to control the infection so that the wounds can be closed with either skin grafts or local flaps. This method can result in salvage of many feet and the maintenance of biped ambulation since the outlook for the diabetic with a major amputation is markedly different from the nondiabetic amputee.

Amputation, Surgical↗
PubMed1977

Cor pulmonale secondary to cleft palate repair. Case report.

A case of cor pulmonale occurred as a complication of a simultaneous palatoplasty and a superiorly-based pharyngeal flap. The patient, like two others found in the literature, had micrognathia. The cor pulmonale was not recognized in the immediate postoperative period but presented two years later with "failure to thrive." Therefore, surgeons must make other members of the health care team aware of this possible complication of combined palatoplasty and pharyngeal flap operations.

Airway Obstruction↗
PubMed1977

A method for the evaluation of minor degrees of breast asymmetry.

We have found the study of split-and-reversed photographs useful in the preoperative evaluation of patients presenting for corrective surgery of the breasts. It puts double emphasis on minor asymmetries, and can be used as an objective tool in planning procedures to correct these, and in evaluating the results. Asymmetry in volume is, however, less readily demonstrated by this technique than is asymmetry of shape.

Breast↗
PubMed1977

Conservative management of the ulcerated diabetic foot.

Four cases are presented of the conservative treatment of the diabetic foot. Using the known principles of wound healing and of management of soft tissue infection, the obviously necrotic or infected tissue was debrided and the wounds were managed conservatively. The use of such debriding adjuncts as a pulsating jet lavage, topical antibacterials, and biological dressings, has controlled infections--so that the foot wounds could be closed then with sking grafts or local flaps. This resulted in the salvage of these feet, with maintenance of biped ambulation.

Adult↗
PubMed1976

The undelayed Mütter flap in head and neck reconstruction.

Twenty-one mastoid-occiput-based shoulder flaps have been used to reconstruct patients with head and neck cancer. When the tip of the flap does not extend beyond the midclavicle, this flap can safely be elevated and transferred into its final position without delay procedures. Not requiring secondary sectioning and implantation, the Mütter flap can successfully be used to reconstruct multiple defects within its arch. Its utility thus rivals the more commonly used medially based deltopectoral flap and forehead flap.

Head and Neck Neoplasms↗