Biomedical subjects
M C Ray
Publications and source records attributed to M C Ray.
The reverse social distance scale.
A "reverse" Social Distance Scale was created by modifying Bogardus's Social Distance Scale, to measure minority groups' perceptions of the social distance established by the majority group between itself and minority groups. The Reverse Social Distance Scale (Guttman's coefficient of reproducibility = 0.99) differentiated between the African American students and the other two groups of minority students in the present sample--Hispanic students and Others--but did not differentiate between the latter two groups. The relationships between the participants' choices of self-identification terms and their scores on the Reverse Social Distance Scale were varied.
Seven ways to empower dying patients.
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Dermatologic manifestations of HIV infection and AIDS.
Infection with HIV can result in many cutaneous disorders, some of which may be the presenting sign of the disease. The cutaneous manifestations may be infectious or noninfectious. This article reviews the numerous cutaneous infectious findings, neoplasms, and dermatoses seen in HIV-infected individuals.
Confluent and reticulated papillomatosis: response to isotretinoin.
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The epidermal nevus syndrome.
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Silent bowel perforation occurring during corticosteroid treatment for pemphigus vulgaris.
We present the case of a patient who experienced a silent colonic perforation while being treated for pemphigus vulgaris with prednisone and azathioprine. Dermatologists are experienced in the management of pemphigus vulgaris with prednisone. We report a well-recognized but rarely reported adverse effect of this standard therapy for pemphigus vulgaris.
Cutaneous infection with Mycobacterium avium-intracellulare scrofulaceum intermediate: a new pathogenic entity.
The atypical or environmental mycobacterial organisms constitute a large group of potential agents in the pathogenesis of cutaneous infection. The most commonly encountered mycobacterial infection after contact with water is Mycobacterium marinum. We report an unusual case of cutaneous mycobacterial infection caused by a newly described opportunistic mycobacteria, M. avium-intracellulare scrofulaceum intermediate. This case emphasizes the difficulty in distinguishing among the species M. avium-intracellulare, M. scrofulaceum, and M. gordonae.
Nonatopic eczemas.
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Familial occurrence of lichen sclerosus et atrophicus. Case reports of a mother and daughter.
A mother and daughter with lichen sclerosus et atrophicus (LSA) are described. Both had lesions restricted to their lower legs. Both patients were positive for HLA-B40, which has been associated with LSA. Sex steroid hormones showed no decrease in dihydrotestosterone, free testosterone, or androstenedione levels in the daughter as was demonstrated in a previous study of this disease, but did show some decrease in androstenedione in the mother. This article provides further evidence for a possible familial predisposition for LSA.
Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.
Several studies have suggested a possible role for IgE antibodies in the pathogenesis of cutaneous hypersensitivity reactions that reach maximum intensity 24 to 48 hr after antigen challenge. The recent availability of murine monoclonal IgE anti-hapten antibodies has made possible the direct examination of the range of cutaneous inflammatory reactions that can be mediated by such antibodies. We have examined the effects of passively sensitizing BALB/c mice with monoclonal IgE anti-dinitrophenyl (DNP) antibody 48 hr before antigen challenge. Inflammatory responses were assessed by measuring ear swelling in mice challenged on the ears with the reactive hapten 2,4-dinitrofluorobenzene (DNFB). Compared with unsensitized controls, the ears of mice passively sensitized with IgE anti-DNP displayed a biphasic pattern of ear swelling after DNFB challenge. An early, transient response (present within 15 to 30 min of challenge and returning to control levels within 4 to 9 hr) was followed by a second, more persistent increase in ear swelling that peaked 24 to 48 hr after challenge. This biphasic pattern of ear swelling seen in IgE-sensitized mice was temporally indistinguishable from that observed in mice conventionally sensitized for allergic contact dermatitis reactions by epicutaneous application of DNFB 5 days before DNFB ear challenge. Antigen specificity of the IgE-mediated contact hypersensitivity reactions was demonstrated by the failure of mice passively sensitized with IgE anti-DNP to display early or delayed ear swelling greater than unsensitized controls when challenged with either of two noncross-reacting haptens, fluorescein isothiocyanate or oxazolone. Mice passively sensitized with a monoclonal IgA anti-DNP antibody (MOPC 315) 48 hr before DNFB challenge failed to display early or delayed ear swelling greater than unsensitized controls. Heat inactivation of the IgE anti-DNP ascitic fluid at 56 degrees C for 30 min completely abolished its capacity to passively sensitize mice for contact hypersensitivity reactions after DNFB challenge. These results document the existence of an antigen-specific, IgE-mediated, delayed-in-time cutaneous hypersensitivity response that can be elicited by epicutaneous challenge (contract) with a reactive hapten.
Granular cell tumor.
The case report presented herein involves a granular cell tumor of the vulva, an uncommon site, with unusual clinical characteristics.
Basement membrane zone.
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Hospice volunteers: a push back to the future.
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Self-sufficiency: examining the bedrock of hospice.
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