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Biomedical subjects

M C Petch

Publications and source records attributed to M C Petch.

At least 91 records · Page 5Linked to original sources
PubMed1984

Computed tomography in patients with hypertrophic cardiomyopathy.

Computed tomography was undertaken in nine patients (age range 33-69 (mean 48.7) years) with hypertrophic cardiomyopathy. The ventricular septum was demonstrated in each patient and shown to be thickened (mean 25 mm at maximum width). The results agreed with those obtained by echocardiography, except in two patients in whom computed tomography showed preferential thickening of the mid-portion of the ventricular septum. The ventricular free wall was not clearly seen. Computed tomography may prove a valuable technique in the assessment of patients with hypertrophic cardiomyopathy.

Adult↗
PubMed1983

Coronary bypasses.

Explore the source record for details and available documents.

Angina Pectoris↗
PubMed1983

M-mode echocardiographic features of severe aortic valve endocarditis.

We describe and discuss the M-mode echocardiographic features in 10 patients with infective endocarditis of the aortic valve requiring surgery. Operative findings and aortic valve histology were obtained in each case. Vegetations were visualized in six out of seven patients (86%) with proven vegetations while pre-existing aortic valve disease masked their echocardiographic recognition in one patient. Diastolic echoes indistinguishable from vegetations were recorded from the ragged edge of a perforated aortic cusp in one patient who at operation had no demonstrable vegetations. Left ventricular outflow tract (LVOT) echoes were seen in five patients. Non-vibrating LVOT echoes were identified as vegetations while rapidly vibrating LVOT echoes were recorded from a flail aortic cusp. Premature mitral valve closure (PMVC) was seen in five out of seven patients (70%) with a short (less than or equal to four month) history of severe aortic regurgitation. Subannular aneurysms were detected in three out of five patients (60%) with this complication. Increased septal and left ventricular posterior wall motion suggestive of severe aortic regurgitation was seen in each case. The detection of a flail aortic valve leaflet, PMVC and subannular aneurysms indicates the need for surgery. The demonstration of vegetations defines a further subgroup of patients who should be managed in a centre with facilities for cardiac surgery. Echocardiography obviated the need for pre-operative cardiac catheterization in nine out of 10 patients (90%).

Aortic Valve↗
PubMed1983

Effects of coronary artery bypass grafting on left ventricular function assessed by multiple gated ventricular scintigraphy.

The effect of coronary artery bypass grafting on global left ventricular ejection fraction and regional contraction was studied in 56 consecutive patients with chronic stable angina pectoris by means of multiple gated ventricular scintigraphy at rest and during dynamic supine exercise before and six weeks after myocardial revascularisation. Before operation, exercise induced a significant fall in ejection fraction and regional wall motion score. Six weeks after operation 52 patients were symptomless. Resting ejection fraction and regional wall motion score were unchanged but during exercise ejection fraction increased significantly, and the previous exercise induced regional wall motion abnormalities were abolished. All four patients with persisting angina showed the same pattern as before operation, with a fall in left ventricular ejection fraction and regional wall motion score during exercise. Multiple gated ventricular scintigraphy affords a safe, objective, reproducible, and non-invasive means of assessing serial ventricular function at rest and during exercise in patients with ischaemic heart disease. The technique confirms that coronary bypass surgery abolishes exercise induced abnormalities of left ventricular function, but has no influence on resting function.

Angina Pectoris↗
PubMed1982

Echocardiographic detection of subvalvar aortic root aneurysm extending to mitral valve annulus as complication of aortic valve endocarditis.

Acute aortic regurgitation as a consequence of infective endocarditis developed in a young man after peritonitis. A large subvalvar aortic root aneurysm extending to the mitral valve annulus together with features of severe acute aortic regurgitation were shown by M-mode echocardiography. The echocardiographic findings were confirmed at operation when obliteration of the aneurysmal space and aortic valve replacement were performed. Postoperative echocardiography confirmed obliteration of the aneurysmal space.

Adult↗
PubMed1979

Uptake of catecholamines by human cardiac muscle in vitro.

Noradrenaline uptake was studied using heart muscle from 102 patients undergoing cardiac surgery. Slices of right atrium were incubated in Krebs-Henseleit solution containing 1.3 x 10(-7) M 3H-noradrenaline. Uptake was lower in failing heart muscle and was inhibited not only by increasing the noradrenaline concentration in the incubating medium but also by adding the drugs desmethylimipramine, amitryptyline, and ouabain.

Adolescent↗
PubMed1979

Concentration of catecholamines in human cardiac muscle.

A trihydroxyindole fluorescent technique was used to measure the concentration of catecholamines in heart muscle taken from 42 patients undergoing open heart surgery. Noradrenaline was the dominant catecholamine and its depletion in the failing heart was confirmed. The distribution of catecholamines within the heart was such that the highest value, 2.64 +/- 0.68 microgram/g, was found in the nonfailing right atrium and the lowest, 0.53 +/- 0.40 microgram/g, in the failing left ventricle.

Adolescent↗
PubMed1979

Cardiac disease in pregnancy.

The problems encountered in the management of pregnant patients with valvular, congenital and ischaemic heart disease are described with the help of illustrative cases. The increased incidence of cardiac dysrhythmias in pregnancy is also discussed.

Adult↗