Search PubMed⌕ Search

Biomedical subjects

M C Perry

Publications and source records attributed to M C Perry.

At least 127 records · Page 7Linked to original sources
PubMed1981

Wilms' tumor in an adult.

We have described an adult with Wilms' tumor treated with surgery, radiotherapy, and chemotherapy. Although the patient responded initially, he died 17 months after diagnosis. A review of the literature in English disclosed only six other adults with Wilms' tumor similarly treated. Only two were long-term survivors, both treated with combination chemotherapy and radiation therapy. Adult Wilms' tumor is rare and carries a more pessimistic prognosis than in children, but it is responsive to radiation and combination chemotherapy.

Adolescent↗
PubMed1981

Eosinophilic meningitis in Hodgkin disease.

Cerebrospinal fluid eosinophilia is an unusual finding that can be caused by Hodgkin disease with central nervous system involvement. To date, only three cases have been reported; in only one of these was central nervous system involvement demonstrated at autopsy. This is the second autopsy-proven case of eosinophilic meningitis associated with intracerebral involvement in Hodgkin disease.

Adult↗
PubMed1981

Resistance to therapy of acute leukemia developing in the course of polycythemia vera.

Thirteen patients in whom acute leukemia developed in the course of polycythemia vera were initially treated with vincristine and prednisone in an attempt at remission induction. None responded, and four died during this initial course of therapy. Induction was then attempted in the nine survivors, using cytosine arabinoside and adriamycin. Only one complete remission of 38 weeks and one partial remission were achieved, while median survival was 32 days. Poor results may reflect both the intrinsic biologic properties of the acute leukemia occurring in this setting and the advanced age of the patients.

Acute Disease↗
PubMed1980

The effect of insulin on the electrophoretic mobility of rat hepatocytes.

The addition of insulin (10 microU) to a suspension of isolated hepatocytes in Krebs-Ringer bicarbonate solution, causes an increase in the negative electrophoretic mobility of the cells from - 1.68 micrometer sec-1 V-1 cm to 2.26 micrometer sec-1 V-1 cm. This observation supports the findings by other workers that the binding of insulin to its receptor leads to a marked change in the membrane.

Animals↗
PubMed1980

Silver stools.

Explore the source record for details and available documents.

Color↗
PubMed1980

Spinal cord glioma following irradiation for Hodgkin's disease.

A 21-year-old patient, after radiation therapy to the mediastinum for Hodgkin's disease, died six years later of a spinal cord glioma, believed to be caused by irradiation therapy. That the x-ray therapy provoked neoplastic changes seems likely, although it could be coincidental.

Adult↗
PubMed1980

The radionindium bone-marrow image in acute (malignant) myelofibrosis.

A patient with a rapidly fatal case of acute myelofibrosis had a radioindium bone-marrow image that unexpectedly showed a normal pattern of distribution, unlike the more typical forms of chronic myelofibrosis or agnogenic myeloid metaplasia. The rapid progression of the disease and the unique handling of radioindium by the reticuloendothelial system may explain the discordant findings.

Acute Disease↗
PubMed1979

Insulin action in isolated fat cells. I. Effects of divalent cations on the stimulation by insulin of glucose uptake.

The effects of divalent cations, in particular Ca2+ and Mg2+, on glucose uptake by rat isolated fat cells in the presence and absence of insulin have been studied. EDTA (disodium salt) was used to deplete the bovine serum albumin present in the incubation medium of endogenous divalent cations prior to incubation with the cells, but was not present in the incubation medium during the incubation of the cells. The removal of Ca2+ and Mg2+ from the incubation medium did not affect the basal glucose uptake, but abolished the ability of insulin to stimulate glucose uptake by the cells. Addition of 25 microM MgCl2 or CaCl2 to the incubation medium restored a significant insulin stimulation, and this stimulation was maximal when 0.1 mM MgCl2 or CaCl2 had been added. SrCl2 and BaCl2 were also effective in restoring the insulin stimulation, but did not substitute fully for Ca2+ and Mg2+ in the incubation medium. Possible explanation for these observations are discussed.

Adipose Tissue↗
PubMed1979

Insulin action in isolated fat cells. II. Effects of divalent cations on stimulation by insulin of protein synthesis, on inhibition of lipolysis by insulin, and on the binding of 125I-labelled insulin to isolated fat cells.

The effects of ommission of Ca2+ and Mg2+ from the incubation medium on three aspects of insulin action in isolated fat cells have been investigated. In the (Ca2+ + Mg2+)-free incubation medium incorporation of L-[14C]leucine into fat cell protein was reduced in the absence of insulin. Insulin stimulated L-[14C]leucine incorporation only in the presence of added CaCl2 or MgCl2. Incubation of the cells in the (Ca2+ + Mg2+)-free medium reduced but did not abolish the ability of adrenaline to stimulate lipolysis or the ability of insulin to inhibit the adrenaline-stimulated lipolysis. Specific binding of 125I-labelled insulin to the fat cells was reduced in the absence of Ca2+ and Mg2+ but was not abolished, even in the presence of EDTA. Ca2+ was routinely the most effective divalent cation in supporting these aspects of insulin action, but similar responses were obtained with Mg2+, Sr2+ and Ba2+. Since insulin still binds to the cells under conditions in which some of the cellular effects of the hormone are abolished, it is suggested that divalent cations may have a role, either direct or indirect, in the processes linking the insulin-insulin receptor complex to certain effector systems in the cells. It is tentatively suggested that this action occurs at the level of the fat cell plasma membrane.

Adipose Tissue↗
PubMed1979

Leukemic iritis with hypopyon.

A patient with acute lymphoblastic leukemia who had received CNS sanctuary treatment with cranial X-irradiation and intrathecal methotrexate displayed his first sign of relapse as iritis with malignant hypopyon. Treatment included topical and subconjunctival corticosteroids and local X-irradiation. Leukemic infiltration of the iris may be the first sign of leukemic relapse. Slit-lamp examination should be performed in all leukemic patients with ocular symptoms.

Adult↗
PubMed1979

Adriamycin and cis-dichlorodiammineplatinum in nonresectable and metastatic carcinoma of the lung.

The combination of adriamycin and cis-dichlorodiammineplatinum (DDP) was evaluated in 20 patients with nonresectable and metastatic carcinoma of the lung. Both drugs were administered at a dosage of 60 mg/m2 intravenously every 3 weeks. The overall objective response rate was 40% (eight of 20 patients) with two complete responses (CR) and six partial responses (PR). Four of eight patients with small cell carcinoma responded (1 CR and 3 PR) and four of 12 patients with nonsmall cell carcinoma responded (1 CR and 3 PR). The median duration of response was greater than 36 weeks. The median survival of responders was 54 weeks. Nausea and vomiting were major side effects but rarely lasted longer than 2 days. Renal and bone marrow toxicities were generally minimal and controlled by dosage reduction. However, there was one death secondary to severe myelosuppression.

Adenocarcinoma↗
PubMed1979

Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.

The three-drug combination of 5-fluorouracil, methyl-CCNU, and daunorubicin was evaluated in 38 patients with unresectable or metastatic carcinoma of the colon. There were five partial responses and one complete response for an overall response rate of 16%. Although toxicity was tolerable, daunorubicin failed to add to the 5-fluorouracil and methyl-CCNU combination.

Adenocarcinoma↗
PubMed1978

Plasmacytomas and mesothelioma.

A patient is reported who developed five plasmacytomas over a four-year period and developed a pleural mesothelioma 12 years later. The relationship of these two entities is discussed and the question of a common environmental carcinogen is raised.

Asbestos↗
PubMed1977

Cautopyreiophagia.

Explore the source record for details and available documents.

Colonic Neoplasms↗