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Biomedical subjects

M C Miller

Publications and source records attributed to M C Miller.

At least 145 records · Page 8Linked to original sources
PubMed1974

Increased potency of four analogues of LH-releasing hormone in man.

Four analogues of LH-releasing hormone (LH-RH) were injected iv. in normal men at a dose of 25 mug: des-Gly-10NH2-LH-RH ethylamide (9-EA-LH-RH); des-Gly-10-NH2-LH-RH propylamide (9-PA-LH-PH), d-ala-6-LH-RH; and D-Ala-6, des Gly10-NH2-LH-RH ethylamide (D-Ala-6,9-EA-LH-RH). Each peptide tested was found to be more potent than LH-RH in releasing LH and, to a lesser extent, FSH. The times of the peak values of LH after the analogues were similar to LH-RH (about 20 minutes). However, LH as well as FSH levels were considerably delayed in returning to baseline after administration of D-Ala-6,9-EA-LH-RH. The half-time disappearances of the 9-EA and 9-PA analogues could be tested and were found to be similar to that of LH-RH. The increased potency and prolonged duration of action of D-Ala-6,9-EA-LH-RH suggest the potential usefulness of this compound in stimulating ovulation and perhaps spermatogenesis.

Follicle Stimulating Hormone↗
PubMed1974

Response to LH-RH in men infused with theophylline.

In an attempt to ascertain certain aspects of the effects of cyclic AMP on the release of LH and FSH in the human being, ten normal men were tested with LH-RH during the infusion of theophylline, a methyl xanthine derivative which inhibits the inactivation of cyclic AMP by phosphodiesterase. The results were compared with the gonadotropin values obtained when LH-RH was injected into the same subjects without theophylline. Although no consistent effect of theophylline was found on either the basal levels of LH and FSH or the magnitude of their increase after LH-RH, an action of cyclic AMP on gonadotropin release is not excluded.

Follicle Stimulating Hormone↗
PubMed1971

Dose-response relationship of luteinizing hormone to luteinizing hormone--releasing hormone in man.

In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 mug resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The present study determined the minimum effective dose as well as the relationship of the response of serum LH and FSH to the dose of LH-RH administered. Three normal men received i.v. injections of 1.1-810 mug of LH-RH. A dose of 10 mug of LH-RH caused a statistically significant elevation in serum LH. 30 mug of LH-RH significantly increased serum FSH levels. A highly significant linear trend was observed in the log dose-response curve. The results indicate that both LH and FSH release occurs in man with doses of LH-RH much lower than previously used and that a linear log dose-response relationship can be obtained.

Adult↗