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Biomedical subjects

M C Marti

Publications and source records attributed to M C Marti.

At least 19 recordsLinked to original sources

[Epidermoid cancers of the anal canal].

The frequency of anal epidermoid carcinoma is constantly increasing. Despite the fact that such cancers are easily detectable through rectal examination, anuscopy or biopsy, diagnosis is delayed in 30 to 50% of the cases due to late and unspecific clinical features, often mistaken for benign lesions. Prognosis of anal epidermoid carcinoma has radically improved due to a better knowledge of the tumour's natural history and of its spreading, to new stage classification (UICC-TNM) and to association fo external or interstitial radiotherapy with chemotherapy. Recovery rates of 80% can be achieved nowadays, 75% of which being obtained with complete sphincter preservation. Subsequent actinic lesions are rare. Surgery is now essentially proposed in these cases of therapeutic failure and consists in a rectal excision. Treatment of such tumours requires a multidisciplinary approach and a close collaboration between surgeon, radiotherapist and oncologist.

Adult

[Ambulatory proctologic surgery].

An increasing number of proctological procedures may be performed on outpatients under extensive local anesthesia or by posterior perineal bloc. Precise selection criteria should be observed. Results of 1233 outpatients procedures are reported.

Adolescent

[Mucosal flaps in the treatment of anal fistula].

Results in the treatment of transsphincteric et suprasphincteric fistulae have been greatly improved with the use of mucosal sliding flaps. The aims of this surgical procedure are: division of the fistulous tract from the primary opening within the anal canal, closure of the primary opening to prevent any repermeabilisation of the tract, excision and curettage of fistulous tract without section of the sphincters. Technical details of this procedure and results achieved in the treatment of 30 consecutive cases are reported.

Adult

[Mucosal flap in the treatment of anal fistula].

A technique of sliding flap repair for the treatment of anal fistulae is described. This technique may prevent sphincter damage. Fifty-five consecutive fistulae have been treated: 23 transsphincteric, 26 intersphincteric, 3 suprasphincteric and 3 rectovaginal fistulae. The fistulous tract is excised and cored out. The intersphincteric space is opened: any gland or inflammatory tissue is removed. The internal opening is excised. The gaps in the internal, as well as in the external, sphincter are closed. The endo-anal wound is closed, using a sliding flap of anorectal mucosa. The ischiorectal wound is left open. Healing has been achieved in every case but one within three weeks, without sphincteric functional defect. Only 3 recurrences have been observed in a mean follow-up of 24 months.

Adult

[Ambulatory proctologic surgery].

Outpatient surgical proctology is nowadays more and more frequently performed. Between 1986 and 1989, 65% of 1149 anal surgical procedures were performed in our institution on an outpatient basis. The various criteria used to select patients fit for ambulatory surgery seemed adequate, as no complications were observed and no patient required secondary hospitalization.

Ambulatory Surgical Procedures

[The past and future of proctology].

Since antiquity, surgical treatments of anorectal lesions were performed by barbers and surgeons; proctology became with time a surgical speciality well defined and recognized todays. History of proctology is illustrated by some important figures and events: St. Fiacre, Felix the surgeon who operated on King Louis XIV's fistula and the acutely thrombosed hemorrhoidal prolapse of Napoleon.

Colorectal Surgery

[Incontinence and supra-continence as complications of anorectal surgery].

Incontinence and supra-continence may complicate various ano-rectal surgical procedures. These troubles result from modifications of the ano-rectal angulation, troubles of rectal sensitivity and neurological pathways, direct or functional sphincter damage and modification of the reservoir function of the rectum. These various disorders should be prevented by careful surgery. If they occur, detailed investigations should help to choose the best therapy: medical and bio-feedback treatment or surgical correction.

Anal Canal

[Epidermoid carcinoma of the anal canal. Value of a multidisciplinary approach].

Great progress has been achieved in the clinical diagnosis, the pathologic patterns study and the treatment of anal epidermoid carcinomas. External and interstitial radiotherapy in association with chemotherapy offers today a real chance to cure these lesions and to save sphincter function. Incidence in actinic lesions is reduced. Salvage abdominoperineal excision is still possible in case of local recurrence without delay in wound healing. 95 cases of anal epidermoid carcinoma were treated in the University cantonal Hospital of Geneva by a combined radio-chemotherapy approach. Local control has been achieved in 86% of tumors less than 4 cm in diameter and 73% of tumors more than 4 cm in diameter. Salvage abdomino-perineal excision has been required in 10% of cases. Abdomino-perineal excision is no more the first treatment of choice of anal epidermoid carcinoma.

Adult

[Rectocele].

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Herniorrhaphy

Sclerotherapy of rectal varices.

Rectal varices represent a rare condition even in cases of portal hypertension. A case of bleeding ano-rectal varices presenting as the first manifestation of portal hypertension is reported. Treatment by sclerotherapy was successful.

Aged

Comparative study of ceftriaxone and cefoperazone in the treatment of acute cholecystitis.

Forty patients with acute cholecystitis were divided into two randomized groups on the basis of the emergency antimicrobial therapy received, and were treated for a period of 5 days. The first group was given ceftriaxone (Rocephin), the second cefoperazone (Cefobis). This concomitant antimicrobial treatment of acute cholecystitis proved to be effective in 85% of the patients; 15% underwent 'à chaud' surgery on the 6th day because of a lack of response to the treatment. Ceftriaxone and cefoperazone proved to be equally effective. Use of ceftriaxone, however, was simpler (one injection a day) and the cost of treatment substantially lower.

Adult