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Biomedical subjects

M C Maroto Vela

Publications and source records attributed to M C Maroto Vela.

At least 19 recordsLinked to original sources
PubMed2000

[Chlamydia pneumoniae and vascular pathology].

An updating of the microbiological and diagnostic characteristics of Chlamydia pneumoniae is carried out, and a hypothesis formulated for its probable role in the production of the atheromatous plaque. Furthermore, the immunological results obtained from patients with peripheral vascular pathology, pneumonia from C. pneumoniae, or other genital processes from C. trachomatis, and a healthy control group are included. The presence of C. pneumoniae was revealed by PCR techniques in biopsies from patients with vascular pathology in a high percentage, particularly in samples from the carotid artery (74%) or the aortic wall (83%). The true pathogenic power of Chlamydia in vascular processes in questioned.

Antibodies, Bacterial↗
PubMed1997

Antigenic and genetic structure of Borrelia burgdorferi.

Lyme borreliosis is a disease caused by the spirochaetes Borrelia burgdorferi, Borrelia afzelii and Borrelia garinii and it is transmitted by ticks. Most of the proteins (outer surface proteins, flagellar proteins and other uncertain location proteins) have a strong antigenic variability. Osp A protein genetic and serological studies facilitated the differentiation of seven serotypes strongly correlated with the known genospecies. The genetic structure of these spirochaetes included a large linear chromosome, several linear microchromosomes as well as a number of circular plasmids.

Antigenic Variation↗
PubMed1991

[Study of viral replication in HbsAg positive chronic hepatitis].

Viral replication seric markers (VRSM), (BeHAg, BcHAg, and DNA-VHB) and the hepatic tissue BcHAg of thirty four patients suffering from chronic hepatopathies (6 PCH, 18 ACH, and 10 cirrhosis) were investigated. The greatest incidence of RVSM was observed in PCH. The combined study using all the markers demonstrated a positive correlation: DNA-VHB and BeHAg (p less than 0,001); DNA-VHB and BcHAg (p less than 0,001); BeHAg and BcHAg (p less than 0,001). The same result was obtained when comparing BcHAg (n) with the rest of RVSM: DNA-VHB (p less than 0,001), BeHAg (p less than 0,001) and seric BcHAg (p less than 0,01). Patients with a most intense histologic activity according to the Knodell index, presented a higher ratio of positive nuclei for BcHAg. The conclusion is that there is a good correlation amongst replication markers, specially hepatic BcHAg and DNA-VHB.

Biomarkers↗
PubMed1990

[Changes in phagocytosis of aerobic bacteria by neutrophils after exposure to subinhibitory concentrations of aztreonam and ciprofloxacin].

In the present research work we are performing a study on the effect of the antibiotic concentrations low minimal inhibitory concentration of aztreonam and ciprofloxacin on phagocytosis of aerobic bacteria by neutrophils (Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa). Both antibiotics induced an increased of phagocytosis by similar mechanisms. In our assay aztreonam and ciprofloxacin would not act directly on granulocyte but they would affect the bacteria increasing the opsonization and phagocytosis.

Aztreonam↗
PubMed1987

The risk of infection with hepatitis B virus in relation to length of hospital employment.

A sero-epidemiological study was carried out on a representative sample of employees of the Hospital Clinico 'San Cecilio' in an attempt to quantify the influence of the time spent working in the hospital on the risk of becoming infected by hepatitis B virus. The results show that the rate of infection by HBV is directly proportional to the length of employment in the hospital, with a probability of infection between 0.6% and 1.4% for each working year.

Employment↗
PubMed1981

[Immunological profile against the hepatitis B virus in different population groups (author's transl)].

To study the immunological profile against the hepatitis B virus 742 sera (107 from the Renal Unit and 635 from other hospital services) were assayed for HBsAg, HBsAc, and HBcAc. The results obtained appear to indicate that the simultaneous determination of the three tests is unnecessary for diagnosis, although it is important for follow-up and prognosis. The isolated measurement of HBsAg is a good diagnostic test, but although it appears early it lasts little, a reason why it should perhaps be complemented with the other tests when considering the time factor. If only one technique is to be made available HBcAc determination seems necessary because it appears simultaneously with the HBsAg and it persists for a long time thereafter. A high degree of positivity of HBsAc and HBcAc was found in dialysis patients, a fact apparent also in the other population groups.

Antibodies, Viral↗
PubMed1979

[Bacteriocinotyping of Klebsiella. A new scheme (author's transl)].

A new typing scheme of the genus Klebsiella for studying the production and different sensitivities towards some standard strains is here proposed. Owing to it, 120 Klebsiellae could be classified. The most frequently bacteriocinotypes found were 778 and 768. The overall amount obtained was of 57 different models of activity. As six clinical experiences have confirmed its efficacy, the practical use may now be faced.

Bacteriocins↗
PubMedDate not supplied

Detection of specific IgG and IgM antibodies in the haemagglutination inhibition test and the enzyme-linked immunoassay for the diagnosis of rubella infection.

A study has been carried out on the sera of 710 women who wished to know their state of rubella immunity using haemagglutination inhibition (HAI) and enzyme-linked immunoassay (ELISA) techniques. The majority of the women presented no symptoms. The ability of HAI to detect low antibody levels (1:8, 1:16) appears to be greater than that of Rubazyme ELISA IgG, employing the recommendations of the manufacturers. The correlation between HAI and IgG values above HAI titres of 1:16 is nearly 100%. In an additional study of 17 primary infections in pregnant women with definite rubella symptoms, the total titre of antibodies was determined by HAI and IgG and specific IgM with ELISA Rubazyme in successive samples. In four cases, IgM was clearly positive and no increase in either HAI or IgG antibodies could be demonstrated over three successive samples taken at an interval of 15 to 20 days. Therefore, we consider it necessary to determine IgM antibodies (evaluating these in the absence of the rheumatoid factor) in every doubtful case occurring in pregnant women, irrespective of whether clinical signs are present or not.

Antibodies, Viral↗