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Biomedical subjects

M C Klein

Publications and source records attributed to M C Klein.

39 records · Page 3Linked to original sources

Comparison of two methods of instruction for the prevention of workplace violence.

The purpose of this study was to compare the effect of the poster session format (PSF) with the traditional film discussion format (FDF) on posttest scores using the Violence in the Workplace Knowledge Test (VWKT) for hospital staff. The 25-item VWKT was developed by the authors. Both groups took this test as the pretest and posttest to determine whether there was a difference in ovrall test scores or a difference in score according to type of violence. The control group included a sample of newly hired staff (n = 51) in general hospital orientation who received training via the FDF method and took the posttest after the program. The experimental group included current staff (n = 84) who received training via the PSF. They "walked through" a poster session at their own pace, completing the posttest as they went along. The comparison of mean pretest scores on the VWKT for the two groups was not significantly different. However, the PSF group had greater improvement in test scores than the FDF group. Further analysis determined that the PSF group significantly improved in both types of violence compared to the FDF group. For this study, using an alternative teaching-learning strategy was more effective than the traditional method. Implications for staff development educators include the need to explore different methods of enhancing learning.

Adult↗

Natriuretic and hypertensive activities reside in a fragment of ACTH.

The hypertensive and natriuretic effects of chronic administration of adrenocorticotrophic hormone (ACTH) cannot be duplicated by the administration of glucocorticoids and/or mineralocorticoids. We investigated the effects of a fragment of this hormone (ACTH4-10) and an analog of the fragment (D-Phe7) ACTH4-10 and found them to have pressor and cardioaccelerator actions in rats as determined by bolus intravenous (i.v.) injections of 30 to 1000 nmol/kg. The pressor and cardioaccelerator effects of (D-Phe7) ACTH4-10 were attenuated by alpha-receptor (phentolamine) and beta-receptor (metoprolol) antagonists. The cardiovascular actions of ACTH4-10 were produced in adrenalectomized or ganglionic-blocked (with mecamylamine) rats. At a lower dose (7 nmol/kg i.v.), ACTH4-10 was natriuretic and had a pattern of activity similar to that of a larger ACTH fragment, alpha-melanocyte-stimulating hormone. Extraadrenal effects of the intact ACTH molecule or the in vivo production of an ACTH4-10-like fragment from ACTH may contribute to the hypertensive and natriuretic actions associated with this hormone.

Adrenalectomy↗