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Biomedical subjects

M C Kay

Publications and source records attributed to M C Kay.

15 recordsLinked to original sources
PubMed1995

Paraneoplastic retinopathy associated with uterine sarcoma.

We present the first reported case of cancer-associated retinopathy with uterine sarcoma. A 65-year-old woman presented in August 1990 with loss of vision, photophobia, and visual field restriction. Antiretinal antibodies were elevated. A diagnosis of cancer-associated retinopathy was made, the patient was started on prednisone, and a workup for malignancy was initiated. The patient was found to have uterine sarcoma. She underwent an extrafascial hysterectomy with bilateral salpingo-oophorectomy followed by eight courses of chemotherapy (carboplatin and cyclophosphamide). After that, the patient's vision improved, her visual field stabilized. She was doing well when last seen, in July 1994. The literature regarding cancer-associated retinopathy and paraneoplastic syndromes associated with gynecologic malignancies is reviewed.

Aged↗
PubMed1991

Ischemic optic neuropathy.

ION typically affects the older population with a sudden decrease in vision, altitudinal visual field loss, and a swollen optic nervehead. Systemic hypertension and diabetes mellitus are the most commonly associated medical problems. Occlusion of the posterior ciliary arterial blood supply to the retrolaminar optic nerve leads to axoplasmic stasis and further compromise of vessels in the nerve substance, which causes the typical funduscopic appearance. Although there is no recognized medical treatment that can reverse the visual loss, a recent report suggests optic nerve sheath decompression for a select group of patients with a gradual decline in vision due to ION may be beneficial. When ION occurs in persons less than 50 years of age, such etiologies as juvenile diabetes mellitus, antiphospholipid antibody-associated clotting disorders, collagen-vascular disease, and migraines should be considered. Rarely, complications of intraocular surgery or acute blood loss may cause an ischemic event in the optic nerve.

Adrenal Cortex Hormones↗
PubMed1986

Optic neuropathy secondary to lymphoma.

Optic neuropathy secondary to lymphomatous infiltration of the optic nerve developed in a patient who was in complete remission from treatment of a non-Hodgkin's lymphoma. This is the first reported case of an isolated optic neuropathy occurring in a patient in clinical and laboratory remission of non-Hodgkin's lymphoma. Recognition that such a complication can occur is important in that prompt treatment may lead to reversal of visual loss, as it did in this patient.

Cranial Nerve Neoplasms↗
PubMed1985

Visual agnosia contrasted with visual-verbal disconnection.

Serial neuropsychological findings are contrasted in two cases: one with a syndrome of visual agnosia, the other with a disorder resulting from visual-verbal disconnection. Both patients were impaired in confrontation naming of objects and pictures, but the patient with visual-verbal disconnection was able to perform tasks of color-object matching and pantomime recognition, whereas the patient with visual agnosia could not do so, demonstrating a failure to establish meaningful nonverbal visual-visual association. Additionally, the performance of the patient with visual agnosia reflected an evolution from the apperceptive to associative forms of the disorder, suggesting that the various impairments of visual identification form a continuum of related disorders.

Agnosia↗
PubMed1985

Orbital apex: correlative anatomic and CT study.

A detailed analysis of the coronal anatomic and CT appearances of the orbital apex is presented. In cadavers, coronal CT 9800 scans of the orbital apex and precisely corresponding cryomicrotomic sections were obtained. The CT appearance of the optic nerve, anulus of Zinn, and cranial nerves III-VI at the superior orbital fissure and orbital apex were determined. These anatomic structures were also demonstrated in clinical CT studies. Practical applications of the anatomic landmarks in evaluating orbital apex tumors are illustrated.

Cadaver↗
PubMed1982

Prosopagnosia.

Three patients with prosopagnosia, and acquired inability to recognize familiar faces usually resulting from cerebrovascular insufficiency, had left-sided visual field defects and color vision abnormalities of central origin. Prosopagnosia, although clinically associated with posterior right hemispheric disease in most cases, represents a disconnection of both occipital poles from the final processing center for facial recognition in the right temporal lobe. This problem can profoundly affect everyday activities requiring visual recognition.

Adult↗
PubMed1982

Prosopagnosia: a double dissociation between the recognition of familiar and unfamiliar faces.

Two cases of a dissociation between prosopagnosia and impaired capacity to match familiar faces were studied. Recognition of familiar faces recovered in the first patient, whereas prosopagnosia persisted in the second patient despite recovery of matching unfamiliar faces and other visuoperceptive skills. This double dissociation is discussed in relation to current views of prosopagnosia.

Adult↗
PubMed1979

Multiple cranial nerve palsies in late metastasis of midline malignant reticulosis.

A 12-year-old man had a sudden onset of multiple cranial nerve palsies after treatment for a necrotizing lesion of the soft palate two years previously. It was thought that neurologic signs were secondary to extension of the local disease and radiation therapy to the base of the brain was begun. The patient died shortly thereafter. A diffuse atypical histiocytic lymphoma involving multiple cranial nerves, lumbosacral nerves, orbital muscles, and other organs was found on autopsy. Initial nasopharyngeal biopsy and autopsy findings were compatible with midline malignant reticulosis, a malignant lesion of the upper airway sometimes associated with metastasis. Our case is the first reported autopsy-documented case, to the best of our knowledge, of metastatic involvement of the cranial nerves in midline malignant reticulosis.

Adult↗
PubMed1978

Orbital hematoma secondary to frontal sinusitis.

A 30-year-old woman had an orbital hematoma with frontal sinusitis. This complication of infection in the paranasal sinuses has not been previously described, but is explainable in anatomic terms. On computed tomographic scanning, the degree of enhancement with contrast infusion was striking and may aid in future diagnosis of this condition.

Adult↗