Biomedical subjects

M C Karamchandani

Publications and source records attributed to M C Karamchandani.

5 recordsLinked to original sources

PubMed1989

Metronidazole vs. erythromycin, neomycin, and cefazolin in prophylaxis for colonic surgery.

A prospective, double-blind, randomized study was undertaken to compare perioperative parenteral metronidazole and erythromycin, One neomycin, and cefazolinhundred fifty-five patients were randomized into two groups by the pharmacy department. The resulting difference between the overall septic complication rate in patients receiving erythromycin, neomycin, and cefazolin (10.9 percent) and the rate in patients receiving metronidazole alone (31.9 percent) was significant. This indicates that an antibiotic to cover aerobic bacteria should be added to the regimen when metronidazole is used.

Cefazolin↗

PubMed1989

Mass screening for colorectal cancer.

A voluntary community colorectal cancer screening project to detect occult blood in the stool of asymptomatic individuals was undertaken; 49,353 Hemoccult II kits were distributed. A total of 23,674 completed kits were returned to a central repository and processed (compliance rate, 48 percent); 851 participants had positive results (3.6 percent). Of the 640 who underwent further medical evaluation, 299 participants (46.7 percent) who had adequate follow-up had no evidence of disease. Diverse disease entities were detected in 341 participants, which was 1.4 percent of those enrolled. Forty-one patients (0.17 percent) showed significant findings that included 29 cancers (0.12 percent) and 12 (0.05 percent) noninvasive malignant polyps. Of the cancers, there were 27 colorectal, one non-Hodgkin's lymphoma, and one carcinoma of the vocal cord. In addition, 107 patients (0.45 percent) had benign polyps and 193 patients (0.82 percent) had various diseases of the gastrointestinal tract and other medical conditions. The cost of the program was modest and the results conformed to those found in previous screening surveys. The heightened public awareness of testing for colorectal disease and the detection of early lesions justifies the guaiac test screening program for mass survey.

Adult↗

PubMed1987

The Bacon pull-through procedure.

Twenty-eight patients who underwent the Bacon pull-through procedure for carcinoma of the midrectum were reviewed retrospectively. The results were comparable to low anterior resection and abdominoperineal resection. Although the indications are limited, it is a viable option in a highly selected group of patients.

Aged↗

PubMed1986

Nephrocolic fistula.

A patient with nephrocolic fistula secondary to perinephric abscess was treated successfully with nephrectomy, colonic resection, and colocolostomy.

Abscess↗

PubMed1984

Vesicoenteric fistulas.

Vesicoenteric fistulas are a challenge to both the urologist and the general surgeon. Awareness of the possibility of an enteric origin of recurrent urinary symptoms should help us prevent the long delays in diagnosis. Thorough and accurate preoperative evaluation will help us make the proper selection as to a one stage or multistage repair. There is room for both in the surgeon's armamentarium, and a wise decision can produce excellent results as seen in this series. When the fistula is of malignant origin, the long-term prognosis remains poor, as it is for any colonic carcinoma extending beyond the serosa and involving a contiguous organ. Fistulas secondary to radiation necrosis and recurrent tumor have an extremely poor outlook with some palliation afforded by a diverting colostomy or a Hartman procedure. Patients with fistulas due to diverticular disease and, to a lesser extent, Crohn's disease can look forward to complete correction with low mortality and morbidity.

Adult↗