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Biomedical subjects

M C Heng

Publications and source records attributed to M C Heng.

64 records · Page 4Linked to original sources
PubMed1984

A simplified hyperbaric oxygen technique for leg ulcers.

A modified technique for administering hyperbaric oxygen with the use of disposable polyethylene bags was evaluated for the treatment of arterial leg ulcers. The potential advantages of the method include fairly low expense, lack of cross-infection, and simplicity in the administration of oxygen. Six men with 27 chronic arterial ulcers were treated with this technique, and five men (ten ulcers) served as controls. In the treated group, 18 of 27 ulcers (5/6 patients) were healed within six to 21 days, with 50% to 90% reduction in size of seven of nine of the remaining ulcers after a three-week period. None were healed in the control group. The treated ulcers healed by 7.8% +/- 1.15% per day compared with -0.5% +/- 0.37% in the control patients. The results indicate that our technique of administering hyperbaric oxygen for the treatment of leg ulcers is simple and effective. It can be adapted for either inpatient or outpatient treatment.

Adult↗
PubMed1983

Pathogenesis of the acquired immune deficiency syndrome (AIDS).

The pathogenesis of the acquired immune deficiency syndrome (AIDS) is still unknown. However, it appears to develop in the milieu of prolonged immunodeficiency. Recently, the disease has reached almost epidemic proportions among homosexuals. Patients with AIDS present primarily with disseminated Kaposi's sarcoma and/or a host of opportunistic infections. A hypothesis is submitted incriminating induced tolerance leading to multiple viral infections and reinfections with cytomegalovirus and others, with or without additional immunosuppression by drugs and chemicals, as the cause of prolonged immunosuppression necessary for the development of AIDS. These viruses, behaving as both tumor inducers and promotors in turn, could result in tumors like Kaposi's sarcoma.

Acquired Immunodeficiency Syndrome↗
PubMed1982

Lithium carbonate toxicity. Acneform eruption and other manifestation.

Manifestations of lithium carbonate toxicity include acneform eruptions, sinus node dysfunction, hyperparathyroidism, hypothyroidism, thyrotoxicosis, extrapyramidal side effects, and renal toxicity, which may present as nephrogenous diabetes insipidus. This report concerns a patient with a toxic reaction to lithium carbonate. The patient initially had acneform lesions, hypoglycemia, hypothyroidism, and nephrogenous diabetes insipidus. Features of lithium carbonate-induced acneform eruptions are emphasized. Renal toxicity from a lithium carbonate overdose is common, and the hazards of prescribing potentially nephrotoxic drugs to such a patient are stressed.

Acne Vulgaris↗
PubMedDate not supplied

Elevated serum chymotrypsin levels in a patient with junctional epidermolysis bullosa. Normalization after UVB therapy with good clinical response.

A 36-year-old Hispanic woman, covered with blisters since birth, was found to have markedly elevated chymotrypsin levels in her serum. This proteolytic enzyme is thought to digest laminin, thus causing separation of the basement membrane at the level of the lamina lucida, corroborating findings on electron microscopy. On the basis that the sun-exposed areas of the skin were relatively less involved, she received a course of UVB therapy, with total clinical clearance of her lesions after 3 weeks. A repeat estimation of serum chymotrypsin at this time revealed normal levels of this enzyme. It is thought that the elevated chymotrypsin levels were either released from the Langerhans cells themselves or from lymphocytes or keratinocytes as a result of Langerhans cell activity, and that the suppression of Langerhans cell activity by UVB inhibited the release of this proteolytic enzyme, resulting in the suppression of blister formation in our patient.

Adult↗