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M C Haugh

Publications and source records attributed to M C Haugh.

24 records · Page 2Linked to original sources
PubMed1986

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles (RT97 and BF10), have all been shown to be specific for phosphorylated epitopes. Treatment of histological sections with alkaline phosphatase prior to immunostaining resulted in reduction of axonal neurofilament staining with all three whilst the neurofibrillary tangles staining with BF10 was unaffected. Antibody 147 was found to recognise weakly some neurofibrillary tangles following alkaline phosphatase treatment. The results presented confirm the presence of structurally abnormal but phosphorylated neurofilaments in neurofibrillary tangles.

Alkaline Phosphatase↗
PubMedDate not supplied

Critical reading of the meta-analysis of clinical trials.

In this paper we shall present the general principles of meta-analysis and will then discuss the various factors needed to evaluate a meta-analysis: description of the problem; definition of the outcome(s) (primary and secondary); methods for identifying and selecting trials for inclusion; statistical methods used; and the presentation and discussion of the results. We shall then examine other problems such as the detection of bias, the validity of the information provided by the meta-analysis, the problem of heterogeneity, the sensitivity and robustness of the meta-analysis, quality criteria for a meta-analysis, and how to locate published meta-analyses. Finally we present a decision algorithm which should help answer the question: should and can the results from the meta-analysis be integrated into clinical practice?

Bias↗
PubMedDate not supplied

[The Cochrane Collaboration: the need for international collaboration].

The Cochrane Collaboration has undergone an unexpected growth since its inauguration during an international meeting in 1993. This collaboration was established in response to the criticisms of a British physician, Archie Cochrane, who criticised the medical profession because it had not organised a critical summary of all relevant randomised controlled trials. The driving force of the collaboration is the collaborative review groups who collect, sort and synthesize data concerning treatment efficacy in their particular area of interest. The Cochrane Centres and the Field Coordinations help them to do this and together the produce the Cochrane Database of Systematic Reviews. The need for international cooperation is obvious because the information necessary to this system is produced throughout the world, and only some of this information is published.

Controlled Clinical Trials as Topic↗
PubMedDate not supplied

[Information system for prescriptors and consumers].

The efficient dissemination of current research data requires a suitable information system and an ideal intermediary as the liaison between the data source and the targeted users, i.e. prescribers and consumers. Here we present the specifications and possible technical solutions which will enable these data to be efficiently transmitted.

Computer Communication Networks↗